Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 296-047-1 | CAS number: 92202-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study to standard protocol and subject to GLP audit
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- Also included a test using one strain of E coli.
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Rosin, fumarated, reaction products with glycerol and pentaerythritol
- EC Number:
- 296-047-1
- EC Name:
- Rosin, fumarated, reaction products with glycerol and pentaerythritol
- Cas Number:
- 92202-14-7
- Molecular formula:
- Not applicable (UVCB substance)
- IUPAC Name:
- Ester of fumarated rosin with glycerol and pentaerythritol, consisting of mainly tri-esters, tetra-esters mixed glycerol- and pentaerythritol- esters and polyesters, as the reactor is charged with a 4:1 stoichiometric ratio of reactants (rosin/fumarated rosin with a glycerol pentaerythritol mixture), and reacted until a low ‘acid value’ is achieved, indicating that most of the –COOH groups of the parent rosin/fumarated rosin have been esterified.
- Details on test material:
- - Name of test material (as cited in study report): rosin, fumarated, reaction products with glycerol and pentaerythritol, CAS 92202-14-7
- Substance type: Chemically modified UVCB
- Physical state: solid
- Analytical purity: assumed 100%
- Lot/batch No.: AN-0400-60
- Expiration date of the lot/batch: March 2001
- Stability under test conditions: assumed stable
- Storage condition of test material: ambient, protected from light
- Other: Supplier - Arizona Chemical
Constituent 1
Method
- Target gene:
- His D3052
His G46
Trp
His C3076
Species / strainopen allclose all
- Species / strain / cell type:
- E. coli WP2 uvr A pKM 101
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S-9 from Aroclor induced rats
- Test concentrations with justification for top dose:
- 60, 190, 560, 1670, 5000 mcg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO;
- Justification for choice of solvent/vehicle: solubility
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Remarks:
- 2-nitrofluorene, sodium azide, mitomycin, 2-aminoanthracene and 9-aminoacridine
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: Direct plate method
Bacterial suspension, test substance and PBS (or metabolic system) (triplicates) mixed with top agar and poured onto minimal agar medium plate. After solidification, the plate was incubated at 37 deg C .
Pre-incubation:
Bacterial suspension, test substance and PBS (or metabolic system) were mixed and incubarted for 20 min at 37 deg C. The mixture was then plated out and incubated as described for the plate incorporation assay.
NUMBER OF REPLICATIONS: 3 for each strain and dose level in both the presence and absence of S-9
NUMBER OF CELLS EVALUATED:
Cells counted in a colony counter - Evaluation criteria:
- Sterility, cytotoxicity, positive controls to show valid increases (>2.5 fold) over background, positive and negative controls within the range expected from historical data, test item to have increased > 2 or 3 fold in revertants over control, dose response expected.
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Key result
- Species / strain:
- E. coli WP2 uvr A pKM 101
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results:
negative with metabolic activation
negative without metabolic activation
Based on an absence of genotoxic/mutagenic effects in a bacterial reverse mutation test with Salmonella typhimurium strains TA 98, TA 100, TA 1535 or TA 1537, or in E. coli strain WP2, with or without metabolic activation, rosin, fumarated, reaction products with glycerol and pentaerythritol is not classifiable for Germ Cell Mutagenicity according to Directive 67/548/EEC, the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) or the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. - Executive summary:
In a bacterial reverse mutation assay with Salmonella typhimurium TA 1535, TA 1537, TA 98, TA 99, TA 100 and Escerichia coli WP2 uvrA conducted in accordance with Guideline protocols, rosin, fumarated, reaction products with glycerol and pentaerythritol CAS 92202 -14 -7 was negative when tested up to 5000 mcg/plate with and without metabolic activation. Concurrent positive controls gave the expected results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.