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Diss Factsheets
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EC number: 248-258-5 | CAS number: 27138-31-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
8. PBT AND VPVB ASSESSMENT
8.1. Assessment of PBT/vPvB Properties
8.1.1. Persistence Assessment
In a modified Sturm test DPGDB was found to have degraded by 6% after 2 days, 62% after 12 days, and by 85% at the end of the 28 -day biotic phase of the test. Substances are considered to be readily degradable in this test if CO2 production is equal to or greater than 60% of the theoretical value within ten days of the level achieving 10%. In the modified Sturm test, DPGDB met these criteria, so may be considered to be readily biodegradable. Therefore, DPGDB would not be rated as persistent according to REACH Annex XIII regulation and would not be rated as a P or vP substance (half-life in fresh-water of greater than 60 days).
8.1.2. Bioaccumulation Assessment
A study measuring bioconcentration was not available for DPGDB. However,evidence of a low bioaccumulation potential is provided by QSAR estimates showing BCF< 200 L/kg using a regression method based upon the experimental log Kow value of 3.9, and using the Arnot-Gobas QSAR method the BCF/BAF values for all trophic levels are < 10 L/kg when biotransformation rates are utilized.For these reasons, and for animal welfare reasons, it is believed that a bioconcentration study is not justified and is not proposed.The QSAR values support a low potential to bioaccumulate and are well below the REACH Annex XIII criteria for B or vB.
8.1.3. Toxicity Assessment
All three trophic levels were represented in aquatic toxicity studies: primary producers represented by algae, plant eating invertebrate animals represented by daphnids, and freshwater fish. LC/EC50 values for all of these organisms were > 1 mg/L. A Daphnid reproduction study generated an NOEC and LOEC value of 2.2 and 5.6 mg/L based on geometric mean measured concentrations. DPGDB is not classified as carcinogenic (category 1 or 2), mutagenic (category 1 or 2) or toxic for reproduction (category 1, 2 or 3). There is no evidence to suggest that DPGDB would be classified as T/R48 or XN/R48 for chronic toxicity. Therefore DPGDB does not meet the T criterion.
8.1.4. Summary and overall conclusions on PBT or vPvB properties
DPGDB is readily biodegradable and therefore is not P or vP. QSAR data suggests a low potential for DPGDB to bioaccumulate. However, as an experimental BCF study is not available for DPGDB the lack of B or vB criterion is not definitive. Aquatic toxicity is minimal and it is not rated as a mutagen or toxic for reproduction and available studies do not support DPGDB as having adverse chronic toxicity or being a carcinogen, therefore the T criterion is no met. Based upon the fact that substances are classified when they fulfil the criteria for all three inherent properties for P, B and T, DPGDB cannot be classified as a PBT or vPvB as it is not Persistent (P) or Toxic (T) based upon experimental data, In addition, QSAR data suggests that DPGDB is not B or vB as well.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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