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EC number: 941-924-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Two recent GLP studies that were performed on the analogue TMP Pelargonate according to OECD guidelines are present for acute toxicity oral and acute toxicity dermal (Salvador, 2014 and 2014a). Both studies did not show any adverse effects up to a concentration of 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Read-across justification
From TMP Pelargonate CAS 127-57 -8
·Carbon number in Fatty Acids: C 9
·Carbon number in Polyol: C6
·Total Carbons in Polyol Ester: C33
·Molecular Weight: 554
To Fatty Acids, C5 -9
·Carbon number in Fatty Acids: C5-9
·Carbon number in Polyol: C6
·Total Carbons in Polyol Ester: C26 - C32
·Molecular Weight: 400 - 540
Both belong to the Trimethylolpropane (TMP) Esters as they have the trimethylolpropane group as a common structural part.
For both substances, it is valid to assume that when metabolism of these polyesters takes place, this firstly leads to the generation of the corresponding fatty acids and of the polyol alcohol.
For substance “TMP Pelargonate" (CAS 127 -57 -8) this relates to trimethylolpropane and three C9 fatty chains.
For substance “TMP Fatty Acids, C5 -9” this also relates to trimethylolpropane and 3 C5-9 fatty chains.
As it is not expected that the acute toxicity is different between C5 and C9 fatty acid chains read-across is considered justified.
Justification for selection of acute toxicity – oral endpoint
There is only one study available on the analogue TMP Pelargonate but this study is a well documented, and performed recent GLP study according to international guidelines.
Justification for selection of acute toxicity – inhalation endpoint
Data on toxicity via the oral and dermal route are available on the analogue TMP Pelargonate . Futhermore, the substance is a viscous oil and the inhalation route of exposure is not considered to be the most relevant one.
Justification for selection of acute toxicity – dermal endpoint
There is only one study available on the analogue TMP Pelargonate but this study is a well documented, and performed recent GLP study according to international guidelines.
Justification for classification or non-classification
Based on the acute toxicity results, showing LD50 values > 2000 mg/kg bw for oral and dermal administration,the substance should not be classified as acute toxic according to the criteria described in EU Regulation No. 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures (CLP)
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