Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 242-768-1 | CAS number: 19035-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987-06-01 until 1987-06-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation: Human and Domestic Animals, Paragraph 81-2: "Acute dermal toxicity study"; U.S. Environmental Protection Agency, Office of Pesticide and Toxic Substances, Washington, D.C., November, 1982
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Potassium hexadecyl hydrogen phosphate
- EC Number:
- 242-768-1
- EC Name:
- Potassium hexadecyl hydrogen phosphate
- Cas Number:
- 19035-79-1
- Molecular formula:
- C16H35O4P.K
- IUPAC Name:
- potassium hexadecyl hydrogen phosphate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Ibm: RORO (SPF), also known as Fü-albino SPF rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: about 8 weeks
- Weight at study initiation: female 162-186 g; male 244-278 g
- Housing: The rats were individually kept
- Diet: NAFAG standard rat maintenance diet, No. 850 (cubic), ad libitum
- Water : tap water, ad libitum
- Acclimatisation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20-24°C
- Humidity: 45-65 %
- Air changes: air-conditioned room
- Photoperiod : 12/12 hrs dark / hrs light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: the test article was moistened with water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back
- % coverage: about 10 % of the total body surface area
- Type of wrap if used: The application site of all rats was covered with an occlusive dressing. The dressing was wrapped around the abdomen and fixed with an elastic adhesive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: the dressing was removed and the skin was cleaned with lukewarm water.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied: 2000 mg/kg bw
- For solids, paste formed: yes - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex
- Details on study design:
- - Duration of observation period following administration: 16 days
- Frequency of observations and weighing: weighing recorded on days 1(immediately before treatment), 5, 9, 12, and 17. Clinical signs were examined every day
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs (behaviour, vivacity, signs of injury, local skin reactions, signs of sickness and abnormality), body weight, and in autopsy a gross examination was performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: After removing of occlusive dressing, reddish maculae became visible on the application site of 3 female rats. These reddish maculae had disappeared at week 2 of the observation period. No other incompatibility reactions appeared.
- Gross pathology:
- With the exception of 2 bulbous nodules in the left-hand uterus horn in 1 female rat, which were formed by proliferative processes and considered to be accidental findings without relation to treatment, no gross findings were seen.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
Five male and 5 female Fü-albino SPF rats were randomly selected for an acute dermal toxicity study. The animals were treated by dermal application of a single dose of 2000 mg/kg of the test substance moistened with water to a shaven area of skin (approximately 10% of the total body surface) on their backs. The application site of all rats was covered with an occlusive dressing which was fixed with elastic adhesive bandages. After 24 hours, the test item was removed with lukewarm water and the skin was inspected whether the treatment caused skin reactions. During 16 days, all animals were observed for toxic signs including mortality and body weight changes. At the end of the study, all rats were examined for gross lesions. No deaths occurred. The LD50 value determined was greater than 2000 mg/kg bw. With the exception of reddish maculae on the application site of 3 female rats, no incompatibility reactions appeared. No effect on the body weight development was observed. No treatment-related gross lesions were observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.