Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The ecotoxicity data in this dossier from Substituted amino acid are read across from Substituted amino acid (2) solution. This read across is considered to be justified because Substituted amino acid (2) solution contains about 50% Substituted amino acid and no ecotoxicity (EC50>100 mg/L) was observed for Substituted amino acid (2) solution in the acute daphnia and algae test. It is therefore considered extremely unlikely that any significant aquatic ecotoxicity will be observed for Substituted amino acid.
Additional information
The ecotoxicity data in this dossier from Substituted amino acid are read across from Substituted amino acid (2) solution. This read across is considered to be justified because Substituted amino acid (2) solution contains about 50% Substituted amino acid and no ecotoxicity (EC50>100 mg/L) was observed for Substituted amino acid (2) solution in the acute daphnia and algae test. It is therefore considered extremely unlikely that any significant aquatic ecotoxicity will be observed for Substituted amino acid.
For substituted amino acid (2) solution, which is an industrial intermediate substance, two aquatic ecotoxicity test results are available and information on the inhibition of micro-organisms presented in activated sludge and in river water.
Based on the results of a short-term aquatic toxicity study, performed according to OECD 201 and GLP principles, substituted amino acid (2) solution inhibited growth of Pseudokirchneriella subcapitata at analytically confirmed nominal concentrations of 18 mg/L and higher. Based on biological relevance, the 72 h-NOErC was determined to be 100 mg/L. The 72 h-ErC50 and 72h-ErC10 and NOEC were determined to be >100 mg/L.
Based on the results of a short-term aquatic toxicity study, performed according to OECD 202 and GLP principles, substituted amino acid (2) solution showed no toxicity towards Daphnia magna in a 48 hour exposure period when tested up to a limit concentration of 100 mg/L. Therefore, the 48h-EC50 was determined to exceed an analytically confirmed nominal concentration of 100 mg/L.
No respiration inhibition occurred to the activated sludge and river water microorganisms present in the inoculum during the first 7 days of a ready biodegradability test at 0.834 mg a.i./L (NOEC = 0.834 mg a.i./L)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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