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Diss Factsheets
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EC number: 285-413-6 | CAS number: 85098-62-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 October 2017 to 18 October 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1010 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: JMAFF 2-7-2-1 The guidelines related to the study reports for the registration application of pesticide (Ref. No. 12-Nousan-8147 on 24 November 2000) & Ref. No.13-Seisan-3986 on 10 October 2001.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Analytical measurements were performed from the control and at the applied test concentration level at the beginning and at the end of the test.
- Vehicle:
- no
- Details on test solutions:
- - Test Material
A stock solution with a concentration of 100 mg/L (nominal) was prepared with the test material and test medium (ISO Medium). As a limit test was carried out, further dilution of stock solution was not performed. The colour of the stock solution was red.
- Untreated Control
The dilution water (ISO-medium) was used without of addition of the test material. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: Szent István University, Department of Aquaculture 2100 Gödöllő, Páter Károly u. 1. – Hungary.
- Age: organisms were less than 24 h old at the beginning of the test
- Feeding during test: no
ACCLIMATION
There was no acclimatisation because the water used was similar to the culture water. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- The reconstituted water (ISO medium) had a total hardness of 247 mg/L (as CaCO3).
- Test temperature:
- 20.1 - 20.6°C (test vessels); 19.8 - 20.9°C (climate chamber)
- pH:
- 7.04 - 7.35
- Dissolved oxygen:
- 8.2 - 8.5 mg/L
- Nominal and measured concentrations:
- 100 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beaker
- Fill volume: at least 5 mL test solution/animal
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration: 4
- No. of vessels per control: 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted water (ISO medium, according to OECD 202) was used as dilution water for both the range finding and definitive tests. The same composition of reconstituted water was used for the tests and for breeding the test animals.
- Intervals of water quality measurement: The water temperature was measured daily, the oxygen concentrations and pH of the control and the test solution were measured at the beginning and at the end of the experiment.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light / 8 hours dark
EFFECT PARAMETERS MEASURED
The immobility or mortality of the Daphnia was determined by visual observation 24 and 48 hours after the start of the test. Those animals not able to swim within 15 seconds after gentle agitation of the test beaker are considered to be immobile.
The number of immobilised animals and the percentage of immobility were determined at 24 and 48 hours.
RANGE-FINDING STUDY
- Test concentrations: 0.1, 1, 10, 100 mg/L
- Results used to determine the conditions for the definitive study: yes
Because a toxic response was not observed during the preliminary concentration range-finding test, a limit test was carried out using only one test concentration (100 mg/L) and one control group in a static system. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- None of the organisms appeared to be immobilised on either the control group or the test material treated group at any observation point. In addition to immobility, no abnormal behaviour or appearance of test animals was detected.
- Results with reference substance (positive control):
- The 24h EC50: 0.64 mg/L, (95 % confidence limits: 0.59 – 0.68 mg/L).
- Reported statistics and error estimates:
- No statistical analysis was performed because of the lack of toxic effects.
The EC50, NOEC, LOEC and EC100 values were determined directly from the raw data. - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the study the 48 hour EC50 was determined to be > 100 mg/L.
- Executive summary:
Acute toxicity of the test material on Daphnia magna was assessed in an Acute immobilisation test, over an exposure period of 48 hours in a static test system. The study was conducted under GLP conditions and in accordance with the standardised guidelines OECD 202, EU Method C.2, US EPA OCSPP 850.1010 and JMAFF 2-7-2-1.
Because no toxic response was observed during the preliminary range-finding test, only a limit test was carried out using only one test concentration (100 mg/L) and one control group in the definitive study.
The test concentration was analytically determined at the start and at the end of the experiment. As the measured concentrations deviated not more than 20 per cent from the nominal, biological results are based on the nominal concentration.
Twenty animals, divided into four replicates (glass beaker) of five animals each were used at the test concentration and for the control.
No statistical analysis was performed because of the lack of toxic effects. The EC50, NOEC, LOEC and EC100 values were determined directly from the raw data. All validity criteria were met during this study.
Under the conditions of the study the 48 hour EC50 was determined to be > 100 mg/L.
Reference
Description of key information
Under the conditions of the study the 48 hour EC50 was determined to be > 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Acute toxicity of the test material on Daphnia magna was assessed in an Acute immobilisation test, over an exposure period of 48 hours in a static test system. The study was conducted under GLP conditions and in accordance with the standardised guidelines OECD 202, EU Method C.2, US EPA OCSPP 850.1010 and JMAFF 2-7-2-1. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
Because no toxic response was observed during the preliminary range-finding test, only a limit test was carried out using only one test concentration (100 mg/L) and one control group in the definitive study.
The test concentration was analytically determined at the start and at the end of the experiment. As the measured concentrations deviated not more than 20 per cent from the nominal, biological results are based on the nominal concentration.
Twenty animals, divided into four replicates (glass beaker) of five animals each were used at the test concentration and for the control.
No statistical analysis was performed because of the lack of toxic effects. The EC50, NOEC, LOEC and EC100 values were determined directly from the raw data. All validity criteria were met during this study.
Under the conditions of the study the 48 hour EC50 was determined to be > 100 mg/L.
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