Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-092-0 | CAS number: 25549-16-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- due to severe irritation, only two animals were used
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triisooctylamine
- EC Number:
- 247-092-0
- EC Name:
- Triisooctylamine
- Cas Number:
- 25549-16-0
- Molecular formula:
- C24H51N
- IUPAC Name:
- tris(6-methylheptyl)amine
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot/batch No.: 0008924462
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories, Netherlands
- Age at study initiation: Approx. 8-9 months
- Weight at study initiation: 3.58 kg – 4.09 kg
- Housing: Single housing
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: Acclimatization for at least 5 days before application
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C +- 3
- Humidity (%): 30 – 70
- Air changes (per hr): ca. 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: dorsolateral part of the trunk
- % coverage: 2.5 cm x 2.5 cm)
- Type of wrap if used: The test patch was secured in position with a semi- occlusive dressing (The test item was covered with a test patch (Idealbinde, Pfälzische Verbandstoff-Fabrik, Kaiserslautern) and Fixomull® stretch (adhesive fleece), Beiersdorf AG)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: The test item was removed at the end of the exposure period with Lutrol®** and Lutrol® / water (1 : 1).
SCORING SYSTEM: according to OECD 404 guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3.2
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: There was no indication of necrosis at study termination.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3.5
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
Any other information on results incl. tables
In the first animal well-defined erythema (grade 2) could be noted immediately after removal of the patch until hour 1. From hour 24 until hour 48, moderate erythema (grade 3) was seen in this animal. This finding increased to severe erythema (grade 4) at hour 72 and decreased to moderate erythema (grade 3) from day 7 until day 14. Slight edema (grade 2) was seen immediately after removal of the patch followed by moderate edema (grade 3) at hour 1 and severe edema (grade 4) at hour 24. This finding decreased to moderate edema (grade 3) from hour 48 to hour 72 and to very slight edema (grade 1) from day 7 until day 14. Both erythema and edema were noted beyond the application area over the entire observation period of 14 days. Moreover, blisters beyond the application area and a whitish discolored application area were seen in this animal at hour 48. Crusty as well as eczema-like skin lesions beyond the application area were seen at hour 72, while brownish discolored plaque-like incrustations and eczema-like skin lesions were seen on day 7. On day 14 scaling and incrustations were noted in this animal.
In the second animal well-defined erythema (grade 2) could be noted immediately after removal of the patch until hour 1. From hour 24 until day 14, moderate erythema (grade 3) was seen in this animal. Very slight edema (grade 1) was seen immediately after removal of the patch followed by slight edema (grade 2) at hour 1 and severe edema (grade 4) from hour 24 until hour 48. This finding decreased to moderate edema (grade 3) from hour 72 until day 7. Erythema and edema were noted beyond the application area. Moreover, blisters, bleeding and a whitish discolored application area beyond the application area were seen in this animal at hour 48. Brownish discolored crusty as well as eczema-like skin lesions beyond the application area were seen at hour 72, while
plaque-like incrustations and eczema-like skin lesions were seen on day 7. On day 14 scaling was noted in this animal, while incrustations had fallen off.
The cutaneous reactions were not reversible in the two animals within 14 days after removal of the patch. The first animal still revealed moderate erythema (grade 3) and very slight edema (grade 1) both beyond the application area, scaling and incrustations.
The second animal revealed moderate erythema (grade 3) beyond the application area and scaling. There was no indication of necrosis at study termination.
Mean scores over 24, 48 and 72 hours for each animal were 3.3 and 3.0 for erythema and 3.3 and 3.7 for edema.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.