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Diss Factsheets
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EC number: 609-030-4 | CAS number: 34825-99-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limit test.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
- Deviations:
- yes
- Remarks:
- Method based on Noakes ansd Sanderson (1989)
- Principles of method if other than guideline:
- The acute (percutaneous) toxicity of the substance was determined using a method based on Noakes and Sanderson (1969)
2 male rats used (body weight 250-300g). A day prior to dosing, 60% of dorsal hair was shorn from each animal.
On day of dosing the skin are to be exposed was examined to rule out skin damage/micro abrasions.
The test material was applied to the skin usinga syringe and the area immediately occluded using plastic and waterproof adhesive tape.
A collar was placed on each animal to prevent interference with the pathed area.
Rats were individually caged for 7 hours and allowed ad libitum access to food and water.
After 7 hours, the collar and occusion were removed. The skin was washed with a warm solution of 0.5% TEGO, then warm water, then dried.
The rats were then rehoused in single-sex groups and allowed ad libitum food and water.
Animals were observed for 14 days after adminstration Body weights were measured on days 0, 7 and 14.
All surviving animals were destroyed on day 14. - GLP compliance:
- not specified
- Test type:
- other: Noakes and Sanderson (1969)
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(diphenylphosphanyl)benzonitrile
- Cas Number:
- 34825-99-5
- Molecular formula:
- C19H14NP
- IUPAC Name:
- 2-(diphenylphosphanyl)benzonitrile
- Test material form:
- solid - liquid: suspension
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Bought from commercial supplier (Bantam & Kingman Ltd).
Body weight range 200-225 g.
On arrival, animals were housed in single sex groups of up to 5 per cage.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- On day of dosing the skin are to be exposed was examined to rule out skin damage/micro abrasions.
The test material was applied to the skin usinga syringe and the area immediately occluded using plastic and waterproof adhesive tape.
A collar was placed on each animal to prevent interference with the pathed area.
Rats were individually caged for 7 hours and allowed ad libitum access to food and water.
After 7 hours, the collar and occusion were removed. The skin was washed with a warm solution of 0.5% TEGO, then warm water, then dried.
The rats were then rehoused in single-sex groups and allowed ad libitum food and water. - Duration of exposure:
- 7 hours followed by 14 day observation period.
- Doses:
- 200 mg/kg/body weight
- No. of animals per sex per dose:
- 2 males
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 of the tested substance is >2000 mg/kg/body weight. No overt signs of toxicity observed.
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