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Diss Factsheets
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EC number: 907-132-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to ASTM standards.
- Justification for type of information:
- Read across is based on the category approach. Please refer to attached category document.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM E-47.01
- Principles of method if other than guideline:
- - Method: ASTM E-47.01, Draft No. 3, 1980 (Standard for Toxicity Tests With the Early Life Stages of Fisheries)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,2'-(ethylenedioxy)diethanol
- EC Number:
- 203-953-2
- EC Name:
- 2,2'-(ethylenedioxy)diethanol
- Cas Number:
- 112-27-6
- Molecular formula:
- C6H14O4
- IUPAC Name:
- 2,2'-[ethane-1,2-diylbis(oxy)]diethanol
- Details on test material:
- - Name of test substance (as cited in study report): Triethylene Glycol (TEG)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Menidia peninsulae
- Details on test organisms:
- TEST ORGANISM
- Common name: tidewater silverside
Study design
- Test type:
- flow-through
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 28 d
Test conditions
- Test temperature:
- 25 +/- 2 °C
- pH:
- 7.69 - 7.73
- Dissolved oxygen:
- 7.1 - 7.2 mg/L
- Salinity:
- 20 +/- 2 parts per hundred
- Nominal and measured concentrations:
- - Concentrations (mg/L): 3.2, 10, 32, 100, 320, 1000 (nominal)
- Concentrations (mg/L): ND*, ND*, 15, 40, 230, 1500 (measured)
* Nondetectable (< 10.0 mg/L) - Details on test conditions:
- TEST CONDITIONS
- Sea water from Santa Rosa Sound was filtered (20-µg filter), aerated, heated in a reservoir to required temperature and delivered to test aquaria
- Salinity was maintained by dilution of natural seawater with deionized freshwater
TEST SYSTEM
- Fish embryos were collected from filter floss on which spawning occured
- Embryos were randomly placed in incubation cups
- Two incubation cups were placed in each of two duplicate 2-L aquaria per treatment
- TEG was introduced with dosing apparatus which delivered 1 L of seawater to each treatment at 5 cycles/h
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- survival of embryos to hatching, survival of fry, and fish weight at 28 days were monitored
Results and discussion
Effect concentrations
- Duration:
- 28 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 500 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Statistically significant differences were found in weight and survival at the highest test concentrations (230 and 1500 mg/L).
---------------------------------------------------------------------------------------------------------------
Weight:
Average weight of fish exposed to 230 mg/L was 18 % less than average control weight, while average weight of fish exposed to 1500 mg/L was 26% less than average control weight.
Survival:
In the 1500 mg/L treatment, the significant effect in combined survival (embryo and fry) was 36 % less than that of the control. Survival of embryos was significantly different from the control at 230 mg/L but not at 1500 mg/L. This suggests that the effect observed in the 230 mg/L treatment may not be caused by toxicity of the test item because the response was not concentration dependent.
Any other information on results incl. tables
Concentration [mg/L] |
Survival [%] |
Average |
Percentage of |
|||
nominal |
measured |
Embryos |
Fry |
Combined |
Wet Weight [mg] |
Control Weight |
control |
ND |
100 |
83 |
83 |
13.2 |
- |
3,2 |
ND |
94 |
93 |
83 |
14.2 |
109 |
10 |
ND |
98 |
89 |
88 |
12.4 |
94 |
32 |
15 |
100 |
62 |
62 |
13.9 |
105 |
100 |
40 |
94 |
81 |
75 |
12.1 |
92 |
320 |
230 |
91 |
86 |
78 |
10.8 |
82 |
1000 |
1500 |
97 |
55 |
53 |
9.7 |
73 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.