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Diss Factsheets
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EC number: 209-057-8 | CAS number: 554-00-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- other: BUA report
- Adequacy of study:
- other information
- Reliability:
- other: BUA report
- Rationale for reliability incl. deficiencies:
- other: No reliability is given as this is a summary entry for the BUA report.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 2,4-Dichloranilin; 2,5-Dichloranilin; 3,4-Dichloranilin
- Author:
- Beratergremium für umweltrelevante Altstoffe (BUA)
- Year:
- 1 994
- Bibliographic source:
- Wissenschaftliche Verlagsgesellschaft, BUA report 140
- Reference Type:
- other: dissertation
- Title:
- Toxizitätsbestimmung von umweltrelevanten Chemikalien mit einem neuen Biotestsystem, Ermittlung physikochemischer Eigenschaften und Ableitung quantitativer Struktur-Toxizitäts-Beziehungen unter Anwendung von Multiregressions- und Hauptkomponenten-Analyse.
- Author:
- Nendza, M.
- Year:
- 1 987
- Bibliographic source:
- Dissertation, 42-65, 106-107, 138-143
- Reference Type:
- publication
- Title:
- Quantitative structure-toxicity relationships and multivariate data analysis for ecotoxic chemicals in different biotestsystems.
- Author:
- Nendza, M. and Seydel, J. K.
- Year:
- 1 988
- Bibliographic source:
- Chemosphere 17, 1575-1584
- Reference Type:
- publication
- Title:
- Toxicities of chloroanilines to Photobacterium phosphoreum and their correlations with effects on other organisms and structural parameters.
- Author:
- Ribo, J. M. and Kaiser, K. L. E.
- Year:
- 1 984
- Bibliographic source:
- QSAR in Environmental Toxicology, pp 319-336
- Reference Type:
- publication
- Title:
- Toxicities of selected chloroanilines to four strains of yeast.
- Author:
- Kwasniewska, K. and Kaiser, K. L. E.
- Year:
- 1 984
- Bibliographic source:
- QSAR in Environmental Toxicology, pp 223-233
- Reference Type:
- publication
- Title:
- Hefe als biologisches Testsystem für ökotoxikologische Untersuchungen. [in German]
- Author:
- Gies A., Pauli W., Benzing M.
- Year:
- 1 989
- Bibliographic source:
- UBA, Chemikaliengesetz Heft 8, Prüfung und Bewertung von Stoffen auf ihre Umweltgefährlichkeit, pp1-2, 153-164, 213
- Reference Type:
- publication
- Title:
- Schadwirkungen von Umweltchemikalien an biologischen Membranen [in German]
- Author:
- Cascorbi I, Roesick E, Wiegener B, Gies A
- Year:
- 1 989
- Bibliographic source:
- In: Umweltbundesamt (ed.): Chemikaliengesetz Heft 8, Pruefung und Bewertung von Stoffen auf ihre Umweltgefaehrlichkeit, S. 165-178, 210-211, Berlin 1989
Materials and methods
- Principles of method if other than guideline:
- BUA report
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dichloroaniline
- EC Number:
- 209-057-8
- EC Name:
- 2,4-dichloroaniline
- Cas Number:
- 554-00-7
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 2,4-dichloroaniline
Constituent 1
Results and discussion
Any other information on results incl. tables
Tests on bacteria
test organism |
Temperature (°C) |
test system |
exposure |
result |
source |
Escherichia coli |
37 |
=> static |
=> exponential growth phase => first measurement 45 minutes after addition of test substance |
IC50 = 62 mg/l |
Nendza (1987), Nendza and Seydel (1988) |
Photobacterium phosphoreum (marine) |
15 |
=> static => inhibition of bioluminescence (Microtox test) |
5 min |
IC50 = 4.0 mg/l |
Ribo and Kaiser (1984) |
15 min |
IC50 = 4.6 mg/l |
||||
30 min |
IC50 = 4.7 mg/l |
Toxicity of 2,4-dichloroaniline on cell proliferation and transport capacity of the cell membrane of yeast (no indication of temperature)
test organism |
Basis for effect |
measured parameters |
exposure |
result |
source |
Rhodotorula rubra (Origin: the shores of,) |
cell proliferation |
cell density |
24 h |
IC50 = 18 mg/l |
Kwasniewska and Kaiser (1984)*
|
Rhodotorula spec. (origin: activated sludge of a municipal STP) |
IC50 = 20 mg/l |
||||
Pichia spec. |
IC50 = 60 mg/l |
||||
Saccharomyces cerevisiae(origin: commercial product) |
IC50 = 117 mg/l |
||||
Saccharomyces cerevisiae |
cell proliferation |
cell density |
24 h |
IC20 = 144 mg/l IC50 = 191 mg/l IC90 = 258 mg/l |
Gies et al. (1989) |
multiplication rate |
exponential growth phase |
IC20 = 83 mg/l IC50 = 185 mg/l IC90 = 356 mg/l |
|||
electrical properties of the cell membrane |
proportion of rotating cells in the electric field at 300 Hertz, in vivo |
1.5 h |
IC20 = 292 mg/l IC50 = 486 mg/l IC90 = 616 mg/l** |
||
transport of purine through the cell membrane into the cell |
initial uptake rate of radiolabelled hypoxanthine, in vivo |
10 min |
IC20 = 178 mg/l IC50 = 373 mg/l IC90 = 648 mg/l** |
Cascorbi et al., 1989 |
|
proton transport through the cell membrane |
ATPase activity in a cell membrane fraction, in vitro |
no data |
IC20 = 141 mg/l IC50 = 259 mg/l IC90 = 437 mg/l |
* 2,4-dichloroaniline was predissolved in dimethyl sulfoxide
** values are above water solubility of 2,4-dichloroaniline (ca. 500 mg/l)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.