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EC number: 233-054-0 | CAS number: 10026-04-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-10-11 to 1993-10-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: NOEC and EC50 are based on a single measurement of the stock solution before dilution and addition to test vessels.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- Cited as Directive 84/449/EEC, C.2 (Acute toxicity for Daphnia)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- The measured Dissolved Organic Carbon Concentration was determined in the fresh stock solution that was used to prepare the test media..
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The hard-to-dissolve test substance was added to the synthetic fresh water to provide a concentration of 1 g/l, and was stirred for 18 hours. Then the solution was filtered and the carbon content was determined. This solution served as the initial solution and contained a DOC value of 433 mg/l, which corresponds to a substance content of 938 mg/l. Test concentrations selected for the main test were 235, 328, 469, 657, and 844 mg/l. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: Daphnia magna were produced through internal self-production. The mother specimens were maintained in M4 medium per Elendt in 1-liter beakers for breeding. The daily amount of nutrient, consisting of Scenedesmus subspicatus, was so measured that the amount added was totally consumed by the specimens. At regular intervals of about four weeks, the young were isolated from the tanks. They were the basis for further breeding. Juveniles (less than 24 hours old) were isolated and used for testing in synthetic fresh water (294 mg/l CaCl2 x 2 H2O; 123 mg/l MgSO4 x 7 H2O; 63 mg/l NaHCO3; 5.5 mg/l KCl; the sum of the Ca2+ and Mg2+ was 4:1, and the ratio of Na+ to K+ was 10:1). - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- -
- Test temperature:
- 20+/-1ºC
- pH:
- 7.0-7.1
- Dissolved oxygen:
- 7.8-8.5 at test termination
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Test concentrations selected for the main test were 0(Control), 235, 328, 469, 657, and 844 mg/l based on the measured concentration in the stock solution.
- Details on test conditions:
- Static exposure tests were conducted at 20 + 1oC. The tests were conducted in the dark. The test vessels were glass cylinders graduated to 10 ml. Four vessels, each containing five neonates, were used for each test concentration and for the control (total of 20 neonates/test concentration). The test organisms were not fed during the test and no aeration was applied. Test organisms were observed for mortality (immobilization) at 24 and 48 hours after test initiation. Dissolved oxygen and pH were measured at test termination for each test concentration and control.
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 844 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: hydrolysis products
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 844 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Remarks:
- measured concentration of stock solution.
- Basis for effect:
- mobility
- Remarks on result:
- other: Exposure is to the hydrolysis products
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 844 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: hydrolysis products
- Basis for effect:
- mobility
- Details on results:
- - Immobilisation of control: 0
- Results with reference substance (positive control):
- The previous test conducted with the positive control, potassium dichromate, showed 20% immobilization at 24-hours with 0.9 mg/l, and 100% immobilization at 24-hours with 1.9 mg/l.
- Reported statistics and error estimates:
- There were no significant effects in the test and therefore statistical analysis of the results was not required
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-hour EC50 value of >844 mg/L and a NOEC of ≥844 mg/L have been determined for the effects of the test substance on mobility of Daphnia magna. It is likely that the test organisms were exposed to the hydrolysis products of the substance.
Reference
There was no immobilisation at any test concentration or in the control group.
Description of key information
Short-term toxicity to invertebrates: 48-hour EC50 >844 mg/l (based on DOC analysis of initial stock solution) (highest concentration tested) (OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)), read-across from an analogous/structurally related substance, tetraethyl orthosilicate (CAS 78-10-4). The EC50 is equivalent to >389 mg/l when expressed in terms of the silanol hydrolysis product.
Key value for chemical safety assessment
Additional information
There are no reliable short-term data available for silicon tetrachloride (CAS 10026-04-7) therefore good quality data from an appropriate structural analogue, tetraethyl orthosilicate (CAS 78-10-4), have been read across. The substances share the same silanol hydrolysis product, monosilicic acid. The other hydrolysis products are hydrogen chloride for silicon tetrachloride and ethanol for tetraethyl orthosilicate.
A 48-hour EC50 value of >844 mg/l (based on DOC analysis of initial stock solution) (highest concentration tested) has been determined for the effects of tetraethyl orthosilicate (CAS 78-10-4) on mobility of Daphnia magna (Hüls, 1989) in accordance with test guideline EU method C.2 and in compliance with GLP. In view of the test media preparation method/exposure regime it is likely that the test organisms were exposed predominantly to the hydrolysis products of the tested substance. The results may be expressed in terms of concentration of the hydrolysis product, monosilicic acid, by applying a molecular weight correction: (MW of silanol = 96.1 / MW of parent = 208.33) * >844 = >389 mg/l.
Refer to IUCLID Section 6, CSR Section 7.0, and the ecotoxicity RAAF report attached in Section 13 of IUCLID or Annex 4 of the CSR, for further discussion of the approach to chemical safety assessment and justification for read across.
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