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Diss Factsheets
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EC number: 205-793-9 | CAS number: 151-56-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-Test, according to Hill, Ass. Food and Drug Off. 18, 1954.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethylenimine
- IUPAC Name:
- Ethylenimine
- Details on test material:
- - Name of test material (as cited in study report): "Aethylenimin rein";
- Physical state: liquid;
- Analytical purity: pure.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- No details reported.
ENVIRONMENTAL CONDITIONS
- not reported.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Undiluted in different amounts.
- Details on dermal exposure:
- TEST SITE
- Area of exposure ca. 5.7 cm² (0.2 mL/kg b.w.); ca. 3-4 cm² (0.1; 0.08; 0.04 mL/kg b.w.); ca. 2-3 cm² (0.02 mL/kg b.w.); ca. 1 cm² (0.01 mL/kg b.w.).
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not reported.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2; 0.1; 0.08; 0.04; 0.02; 0.01 mL/kg b.w. - Duration of exposure:
- not reported.
- Doses:
- 8.3; 16.6; 33.2; 66.4; 83 and 166 mg/kg b.w. calculated using the density of 0.83 g/cm³ at 24°C, corresponding to 0.01; 0.02; 0.04; 0.08; 0.1 and 0.2 mL/kg b.w.
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 4 - 5 weeks.
- Frequency of observations and weighing: Weighing was performed only at the beginning of the study for dose calculation. Observation of clinical signs was performed several times on the day of administration and once daily afterwards with the exception of weekends and on holidays.
- Necropsy of survivors performed: yes. - Statistics:
- No statistics were performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 12.45 mg/kg bw
- Mortality:
- Application of 66.4, 83.0 and 166.0 mg/kg b.w.: All rats perished after 1 day (166.0 mg/kg b.w.), after 2 - 5 days (83.0 mg/kg b.w.) or after 2 - 6 days (66.4 mg/kg b.w.).
Application of 33.2 mg/kg b.w.: 14 rats perished 3 - 11 days after application. The surviving animals were sacrificed after 5 weeks.
For summary see table below. - Clinical signs:
- other: Application of 66.4, 83.0 and 166.0 mg/kg b.w.: Immediately after application hyperexcitability and after 2 hours apathy was observed. Application of 33.2 mg/kg b.w.: These animals showed transient apathy and recovered within 24 hours. Application of 8.
- Gross pathology:
- Application of 66.4, 83.0 and 166.0 mg/kg b.w.: Animals showed congestion in the renal medulla. Renal papillary necrosis occurred only in those animals that were treated with 66.4 and 83.0 mg/kg b.w. and died within 2-6 days.
Application of 33.2 mg/kg b.w.: Animals had renal papillary necrosis. The animals that were sacrificed after 5 weeks exhibited indications of healing processes.
Application of 8.3 and 16.6 mg/kg b.w.: Perished animals showed renal papillary necrosis. Regarding the animals that were sacrificed after 4 weeks, 4 of 7 animals that were treated with 16.6 mg/kg b.w. and 6 of 15 animals that were treated with 8.3 mg/kg b.w. showed no signs of nephropathy.
Any other information on results incl. tables
Dose |
Animals |
Exitus |
Pathological, histological findings in the kidney |
|
mL/kg b.w. |
N |
N |
Within (days) |
|
0.2 |
20 |
20 |
1 |
Congestion of medulla renalis |
0.1 |
20 |
20 |
2-5 |
Congestion of medulla renalis |
0.08 |
20 |
20 |
2-6 |
Congestion of medulla renalis , necrosis of renal papillae |
0.04 |
20 |
14 |
3-11 |
necrosis of renal papillae |
0.02 |
20 |
13 |
6-17 |
necrosis of renal papillae |
0.01 |
20 |
5 |
12-13 |
necrosis of renal papillae |
N= number of animals.
Value not calculated in the study. Cited in Zeller et al., 1970. Probably calculated using the data from this study.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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