Registration Dossier
Registration Dossier
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EC number: 201-251-0 | CAS number: 80-10-4
Endpoint summary
Administrative data
Description of key information
There is no reliable acute toxicity data. However, in accordance with Column 2 of REACH Annexes VII and VIII, acute toxicity studies (required in Section 8.5) do not need to be conducted as the substance is classified as corrosive to skin.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- In accordance with Column 2 of REACH Annex VII, the acute oral toxicity study (required in Section 8.5.1) does not need to be conducted as the substance is classified as corrosive to skin.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the inhalation route (required in Section 8.5.2) does not need to be conducted as the substance is classified as corrosive.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the dermal route (required in Section 8.5.3) does not need to be conducted as the substance is classified as corrosive.
Additional information
Dichloro(diphenyl)silane hydrolyses very rapidly (half-life 10 seconds at pH 7) in contact with water and moist air releasing two moles of hydrogen chloride (HCl) for one mole of parent molecule. It is therefore classified as corrosive and acute toxicity testing is not appropriate.
Justification for classification or non-classification
In the absence of appropriate measured data, the substance is not classified for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
