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EC number: 203-444-5
CAS number: 106-93-4
Rats inhaled EDB 23 hr a day for 10 days starting on Day 6 of gestation.
The values for the chamber concentration, which were determined at
intervals during the exposure, were averaged to yield a time-weighted
average concentration for that day. The average (range) of these values
for each chamber during the 17-day period required to expose all of the
animals was 20 (15-22), 38 (32-42), and 80 (7 l-84) ppm of EDB.
Pregnant rats inhaled ethylene dibromide (EDB) at concentrations of 20,
38, and 80 ppm for 23 hr a day. The exposures started on Day 6 of
gestation and lasted for a total of 10 days. Observations were made on
maternal welfare and fetal development. The results of this study
indicated that adverse effects on maternal welfare, as measured by
weight gain, feed consumption, and survival, were
observed in rats; and that morphological changes were observed in
fetuses from dams exposed to EDB. However, the latter occurred at
concentrations that also affected maternal welfare. Consequently, EDB
was judged to have little primary effect on development in this study.
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