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EC number: 203-444-5
CAS number: 106-93-4
In the present study, both sexes of rats were exposed to one of three
concentrations of EDB. Adverse effects on survival, body weight, and
food consumption were consistently observed at the highest
concentration. In addition, adverse effects on reproduction were also
observed at this concentration. Males exposed to 89 ppm had reduced
testicular weights and serum testosterone concentrations, atrophy of the
reproductive organs, and failed to impregnate any female. Females
exposed to 80 ppm had abnormal estrous cycles at the end of exposure;
however, this change was reversible and some females successfully mated
and produced normal litters. In contrast, the various parameters of
reproduction examined were normal in both males and females exposed to
the low and middle ccncentrations of EDB.
Table 1. Body weight and food consumption of male and female rats
exposed to EDB.
a=Mean value for 30 -33 animals/concentration (one to two/cage).
c=Significantly different from control (Dunnett's test).
d=Mean values for 20 animals/concentration (one to two/cage).
Table 2. Fertility of Male rats exposed to EDB for 10 weeks and
then housed with unexposed Females.
a=Number of males impregnating at least one female. One males housed
with two females each week.
b=Significantly different from control (Fisher exact probability test).
Table 3. Reproductive performance of unexposed female rats mated
with males exposed to EDB.
b=None of the females were pregnant.
The effects of ethylene dibromide (EDB) on reproduction were studied in
both sexes of rats. Males inhaled average daily concentrations of 19,
39, and 89 ppm of EDB 7 hr/day, 5 days/week, for 10 weeks. Mortality and
morbidity occurred in the group exposed to the high concentration. In
addition, males in this group had reduced testicular weights, reduced
serum testosterone concentrations, and failed to impregnate any females
during a 2-week mating period. Atrophy of the testes, epididymis,
prostate, and seminal vesicles was observed in these males. The
reproductive performance of males exposed to 19 or 39 ppm of EDB was not
Females inhaled average daily concentrations of 20, 39, or 80 ppm of EDB
7 hr/day, 7 days/week, for 3 weeks. Mortality and morbidity occurred in
the group exposed to the high concentration. Females in this group did
not cycle normally until several days after the termination of exposure.
The reproductive performance of females exposed to 20 or 39 ppm of EDB
was normal. Pregnant females in all groups produced normal litters, and
histopathological examination of the ovary and uterus did not reveal
lesions that would impair reproductive performance. Thus, adverse
effects on reproduction were observed in both sexes of rats only at
concentrations of EDB that also produced mortality and morbidity.
Therefore, it was not possible to attribute the reproductive effects
directly to EDB.
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