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EC number: 203-444-5
CAS number: 106-93-4
McCollister et al, 1956, was conducted on rats (similar to OECD 401 guideline not under GLP conditions) and reported an acute oral LD50 value of 140 mg/kg bw.
Acute toxicity: oral
McCollister et al, 1956, was conducted in a similar manner to the OECD
401 guideline and was therefore allocated a reliability score of 2
because pre-GLP. The study was conducted on Rats and reported an acute
oral LD50 value of 140 mg/kg bw.
Rowe et al, 1952, was also conducted in a similar way to OECD 401,
however deviations were greater than McCollister et al, 1956, and so
this study is presented as supporting information only. Rowe et al,
1952, reported an acute oral LD50 value of 146 mg/kg bw for male rats
and 117 mg/kg bw for female rats, these results support the key value
above. Rowe et al, 1952, also reported acute oral LD50 values for Mice
(Female: 420 mg/kg bw), Rabbits (Female: 55 mg/kg bw), Chicks (Mixed
sex: 79 mg/kg bw) and Guinea pigs (Mixed sex: 110 mg/kg bw).
Acute toxicity: inhalation
Rowe et al, 1952, was the only available information for this route of
administration. The study was given a reliability score of 2 as the
study was based upon a novel methodology. Groups of rats and groups of
guinea pigs were exposued to vapour inhalation of the substance at test
concentrations of 100, 200, 400, 800, 1000, 3000, 5000, 10000ppm for
rats and 200ppm and 400ppm for guinea pigs. The exposure period varied
from 0.02 to 16 hours.
An acute inhalation (4 hour) LC50 of >200ppm (equivalent to >1.54 mg/l)
was set based upon acute toxic effects.
Acute toxicity: dermal
Based upon dermal data for other endpoints the substance is expected to
be dermally absorbed and systemically toxic, however in the absence of
any available acute dermal toxicity data it is not possible to assess
the extent of acute toxicity via the dermal route at this time. As the
substance is already classified for acute dermal toxicity and as no
dermal exposure to the registered substance from the identified use is
expected further testing for this endpoint is considered to be
The registered substance is currently classified as Acute Tox 3; Toxic
if swallowed, Toxic in contact with skin, Toxic if inhaled, according to
Annex VI of EC Regulation 1272/2008 and R23/24/25: Toxic by inhalation,
in contact with skin and if swallowed according to Annex I of 67/548/EEC.
The information which is currently available supports this assessment
therefore no changes to the acute toxicity classifications are proposed
at this time.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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