Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-444-5
CAS number: 106-93-4
Holcombe et al, 1985, is considered to be of adequate reliability and relevance to fulfill the regulatory endpoint for long-term toxicity testing to fish.
Holcombe et al, 1985, was conducted in a similar manner to the EU Method
C.15 (Fish, Short-term Toxicity Test on Embryo and Sac-fry Stages) and
was performed on the Japanese Killifish (Medaka) (Oryzias latipes)
for an exposure period of 28 days in a flow-through freshwater test
system. The test was conducted using test concentrations of 1.50, 2.52,
5.81, 9.62 & 20.3 mg/l with 120 fish exposed per concentration. Holcombe
et al, 1985, reported a 28-day NOEC of 5.81 mg/l, a 28-day LOEC of 9.62
mg/l and a 28-day MATC of 7.48 mg/l based upon growth rate.
Based upon the level of reporting in the original text the study was
awarded a reliability score of 2 according to the criteria of Klimisch
et al, 1997, and was therefore considered to be of sufficient
reliability to fulfill the regulatory endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tato webová stránka používá cookies, aby se vám naše stránky používaly co nejlépe.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again