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Diss Factsheets
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EC number: 201-696-0 | CAS number: 86-74-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to guideline study, conducted under more stringent test conditions than common today, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Consumer Product Safety Commission, USA; Code of Federal Regulations, Title 16, Section 1500.41
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- : exposure period is 24 h, solid TS was suspended (10% carbazole suspension in 0.5% carboxymethyl cellulose), occlusive wrapping, test substance is applied on intact and on scarified skin, scores are taken immediately after removal.
- GLP compliance:
- no
- Remarks:
- pre-GLP test
Test material
- Reference substance name:
- Carbazole
- EC Number:
- 201-696-0
- EC Name:
- Carbazole
- Cas Number:
- 86-74-8
- Molecular formula:
- C12H9N
- IUPAC Name:
- 9H-carbazole
- Details on test material:
- - Name of test material (as cited in study report): Produkt 110 804 received from Rütgerswerke AG
- No further information on test material
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: one side of the rabbit's back was shaved the other was shaved and scarified
- Vehicle:
- other: carboxymethyl cellulose (CMC)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g (5 mL)
- Concentration (if solution): 10 % test substance suspension in 0.5% carboxymethyl cellulose
VEHICLE
- Concentration (if solution): ~ 90 % - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: ca 2,5 x 2.5 cm
- Type of wrap if used: no data (but occlusive wrapping)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
SCORING SYSTEM: according to Draize (ETAD recommendation)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 0 h and 48 h after removal of patch
- Score:
- 0.5
- Max. score:
- 8
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: score includes readings for intact and for scarified skin.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 0 h and 48 h after removal of patch
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: score includes only readings for intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 0h and 48 h after removal of patch
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: score includes only readings for intact skin
Any other information on results incl. tables
Immediately after removal of the patches, one animal showed a score of 1 for erythema and edema. For two other animals, either the erythema score or the edema was 1. All other animals did not show any dermal effects after application of the test substance suspension for 24 h.
The effects observed were reversible within 48 h. At the 48 h reading, no irritating effects could be observed any more.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a primary skin irritation test with 6 rabbits, minimal transient irritation effects (score 1 for erythema and edema) were observed on the intact skin of three animals after application of 0.5 mL of a 10% suspension of carbazole in 0.5% carboxymethyl cellulose (50 mg test substance). Effects subsided within 48 h.
The mean score for erythema and edema was 0.167 for the reading immediately after removal of patch. No classification is required according to EU regulations.
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