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EC number: 417-220-1 | CAS number: 37441-29-5 ATIPACL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 5th Jannuary, 1995 to 19th Jannuary, 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- according to EEC directive 92/69 B3
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 5-amino-2,4,6-triiodo-1,3-benzenedicarbonyldichloride
- EC Number:
- 417-220-1
- EC Name:
- 5-amino-2,4,6-triiodo-1,3-benzenedicarbonyldichloride
- Cas Number:
- 37441-29-5
- Molecular formula:
- C8H2Cl2I3NO2
- IUPAC Name:
- 5-amino-2,4,6-triiodobenzene-1,3-dicarbonyl dichloride
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Han1bm:Wist (outbred, SPFQuality) .
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Rationale for alternative/additional species to rat: Recognised by international guidelines as the recommended test system (e.g. OECD, EEC).
- Source: BRL Ltd., Basel, Switzerland.
- Age at study initiation: Approx. 11 weeks.
- Weight at study initiation: Within ± 20% of the sex mean
- Housing: Individually housed in labelled polycarbonate cages containing purified sawdust as bedding material (Woody SPF, supplied by B.M.I., Helmond, The Netherlands).
- Diet: Free access to standard pelleted laboratory animal diet (Kliba 343 from Klingentalmuhle AG, Kaiseraugst, Switzerland).
- Water: Free access to tap-water.
- Acclimation period: at least 5 days before start of treatment under laboratory conditions
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C
- Humidity (%): 50%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 hours artificial fluorescent light and 12 hours dark per day.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Remarks:
- Specific gravity 0.92
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back clipped free of hair
- % coverage: 25 cm2 (5x5 cm) for males and 18 cm2 (3.5~5 cm) for females
- Type of wrap if used: a gauze patch fixed successively to aluminium foil and flexible bandage (Coban, 3M, S t . Paul, U.S.A.), with drops of petrolatum.
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: Mortality/Viability: twice daily. Body weights: Days 1 (pre-administration), 8 and 15.
- Necropsy of survivors performed: yes
- Clinical signs including body weight: At periodic intervals on the day o f treatment (day 1) and once daily thereafter, until day 15. . - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Lethargy and/or hunched posture was observed on 2 males on days 2 and 3.
- Gross pathology:
- None
- Other findings:
- Yellow discoloration of the treated skin on day 2 in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified as harmful/toxic according to CLP Regulation (EC) 1272/2008
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
The acute dermal toxicity of the test item was evaluated in an experimental study according to OECD Guideline No. 402, "Acute Dermal Toxicityn and EU Method B.3.
The substance was administered to five rats of each sex by dermal application at 2000 mg/kg body weight for 24 hours. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed at the end of the experimental period (day 15).
No mortality occurred. Lethargy and/or hunched posture were observed in two males on days 2 and 3. Yellow discolouration o f the treated skin area was seen in all animals on day 2.
Body weight gain during the observation period was within the range expected for rats used in this type of study. No abnormalities were found in the animals at macroscopic post mortem examination.
The dermal LD50 value of the test item in rats was established as exceeding 2000 mg/kg body weight.
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