Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-685-6 | CAS number: 109-59-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
In an approved guideline OECD301F study conducted to GLP, isopropyl glycol ether was only 23% biodegraded at 28 days in a predominatly unadapted domestic sewage sludge and therefore failed to meet the criteria for ready biodegradability. The result may have been better in an adapted industrial sludge rather than an unadapted domestic sludge. In an OECD301C guideline and GLP study, a test with activated sludge of 2-isopropoxyethanol resulted in 8% degradation after 28 days cultivation period. Part of 2 -isopropoxyethanol was converted to 2 -(1 -methylethoxy)ethanoic acid during the cultivation period. Biodegradation testing with the isomer of isopropoxyethanol (n-propoxyethanol) conducted under a modified guideline method showed the latter to be readily biodegradable at 20 days under aerobic conditions with non-acclimated sewage microorganisms. The US EPA Biowin v. 4.10 QSAR model predicts that both n and isopropoxyethanol will be readily biodegradable. The results in 6 of the 7 models within the QSAR gave identical predictions and in only one did it predict that n-propoxyethanol would be readily biodegradable but isopropoxyethanol would not be. The data suggests that isopropoxyethanol is less readily degradable than n-propoxyethanol and cannot, on present information, be considered readily biodegradable.
In a study that followed the principles of a guideline activated sludge similation test, a reactor system set up to model the WWTP used on the site of a manufacturer was dosed with increasingly levels of isopropyl glycol ether. The sludge reactor influent used was the same as used for the full scale plant as was the activated sludge. When running with an influent stream containing up to 150ul/litre of isopropyl glycol ether, the reactor ran with a degradation efficiency of 97%. There was evidence of adaptation occuring and also complete removal of all biologically available oxygen from the influent stream.
The overall available data suggests however that this substance can be considered inherently biodegradable for the purposes of risk characterisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.