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EC number: 941-154-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The read-across source substance LAB Sulfonic Acid was tested and found to be irritating to both the skin and eyes of test animals. Skin and eye irritation studies in rabbits indicate that the read-across source substance LAB Sulfonic Acid is corrosive to skin and a persistent moderate irritant and damaging to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see read-across document
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: Mean of 1, 24, 48 and 72 hours.
- Score:
- 5.25
- Max. score:
- 6
- Reversibility:
- not reversible
- Remarks on result:
- other: highly irritating
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hr readings
- Score:
- 5.33
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 14 days
- Other effects:
- Significant reddening effects were observed at all times and were persistent. Bloody wounds and scar formation were observed through at least observation day 9.
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- Result: Highly irritating
- Executive summary:
The shaved backs of three male and three female rabbits were exposed for 4 hours to 0.5 ml of the test substance and observed for up to 14 days. Significant reddening was observed throughout at least day 9. Swelling was perceptible throughout and appeared to become more noticeable with time. Bloody wounds and scar formation were observed through at least observation day 9. The test substance is considered highly irritating to the skin of rabbits. The test substance is considered corrosive to skin according to OECD GHS guidelines.
Reference
Results of Skin Irritation Study in Rabbits
Observation |
Endpoint |
Male 11499 |
Male 11887 |
Male 11901 |
Female 11580 |
Female 11658 |
Female 11802 |
1 hr |
Erythema |
4 X |
4 X |
4 X |
4 X |
4 X |
4 X |
1 hr |
Edema |
1 |
1 |
1 |
1 |
1 |
1 |
24 hrs |
Erythema |
4 X |
4 X |
4 X |
4 X |
4 X |
4 X |
24 hrs |
Edema |
1 |
1 |
1 |
1 |
1 |
1 |
48 hrs |
Erythema |
4 X |
4 X |
4 X |
4 X * |
4 X |
4 X * |
48 hrs |
Edema |
1 |
1 |
1 |
1 |
1 |
1 |
72 hrs |
Erythema |
4 * |
4 * |
4 X * |
4 X * |
4 * |
4 * |
72 hrs |
Edema |
2 |
2 |
2 |
2 |
2 |
2 |
6 days |
Erythema |
4 + |
4 * |
4 * |
4 * - |
4 + |
4 + - |
6 days |
Edema |
2 |
2 |
2 |
2 |
2 |
2 |
9 days |
Erythema |
W |
W |
W |
+ |
W |
+ |
9 days |
Edema |
C N |
C N |
N |
|
N |
W |
14 days |
Erythema |
N |
N |
N |
N |
N |
N |
14 days |
Edema |
N |
N |
N |
N |
N |
N |
X - Necrosis in application area bordered by swelling
* - Application area hardened
+ - Wavy crust
- - Application area paper-like
W - Bloody wounds
C - Crust formation
N - Scar formation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see read-across document
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, and 72 hrs and 6 days
- Score:
- 46.9
- Reversibility:
- not fully reversible within: 6 days
- Remarks on result:
- other: moderately irritating
- Irritant / corrosive response data:
- Results indicated a moderate irritancy, but because of the intensity of the necrosis formation, the study was stopped at day 6.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Result: moderately irritating
- Executive summary:
The eyes of six rabbits were treated with the test substance and observed for six days. Results indicate that the substance was moderately irritating but because of the intensity of the necrosis formation the study was stopped at day 6.
Reference
Results of Eye Irritation Study in Rabbits
Observation |
Endpoint |
Male 11655 |
Male 11715 |
Male 11771 |
Female 11798 |
Female 11804 |
Female 11838 |
1 hr |
Cornea - degree |
1 |
1 |
2 |
2 |
2 |
1 |
1 hr |
Cornea - range |
4 |
4 |
4 |
4 |
4 |
4 |
1 hr |
Iris |
1X |
1X |
1X |
1X |
1X |
1X |
1 hr |
Conjunctiva - redness |
3N |
3N |
3N |
2N |
3N |
3N |
1 hr |
Conjunctiva - edema |
1 |
1 |
1 |
1 |
2 |
2 |
1 hr |
Conjunctiva - exsudation |
3 |
3 |
3 |
3 |
3 |
3 |
24 hrs |
Cornea -degree |
1 |
1 |
2 |
2 |
3C |
1 |
24 hrs |
Cornea - range |
4 |
4 |
4 |
4 |
2 |
4 |
24 hrs |
Iris |
1* |
1* |
1* |
1* |
1*- |
1* |
24 hrs |
Conjunctiva - redness |
3N |
3N |
3N |
3N |
3N S |
3N |
24 hrs |
Conjunctiva - edema |
2 |
2 |
2 |
2 |
2 |
3 |
24 hrs |
Conjunctiva - exsudation |
2 |
2 |
2 |
2 |
2 |
2 |
48 hrs |
Cornea ¿ degree |
1 |
1 |
2 |
2 |
3C |
1 |
48 hrs |
Cornea - range |
4 |
4 |
4 |
4 |
2 |
4 |
48 hrs |
Iris |
1* |
1* |
1* |
1* |
1*- |
1* |
48 hrs |
Conjunctiva ¿ redness |
3N S |
3N |
3N S |
3N S |
3N S |
3N S |
48 hrs |
Conjunctiva ¿ edema |
2 |
1 |
1 |
1 |
2 |
3 |
48 hrs |
Conjunctiva - exsudation |
2 |
2 |
2 |
2 |
2 |
2 |
72 hrs |
Cornea - degree |
1 |
1 |
1 |
2 |
4C |
1 |
72 hrs |
Cornea - range |
4 |
2 |
4 |
4 |
2 |
4 |
72 hrs |
Iris |
1X |
1X |
1* |
1* |
1*- |
1* |
72 hrs |
Conjunctiva - redness |
3N S |
3N S |
3N S |
3N S |
3N S |
3N S |
72 hrs |
Conjunctiva - edema |
2 |
2 |
2 |
2 |
2 |
2 |
72 hrs |
Conjunctiva - exsudation |
2 |
2 |
2 |
2 |
2 |
2 |
6 days |
Cornea - degree |
2 |
2 |
2 |
2 |
4C |
2 |
6 days |
Cornea -range |
3 |
3 |
2 |
3 |
2 |
4 |
6 days |
Iris |
1X |
1X |
1* |
1* |
1*- |
1* |
6 days |
Conjunctiva - redness |
3N S L |
3N L |
3N L H |
3N S L |
3N S L |
3N S L |
6 days |
Conjunctiva - edema |
2 |
2 |
2 |
2 |
2 |
2 |
6 days |
Conjunctiva - exsudation |
2 |
1 |
2 |
2 |
2 |
2 |
C - Cornea cloudy
X - Parts of the iris turned red
* - Iris turned red
- - Retarded iris reaction
N - Necrosis and corrosion of the conjunctiva
S - Secretion formation
L - Lids became encrusted
H - Holding head inclined
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The read-across source substance LAB Sulfonic Acid was tested and found to be irritating to both the skin and eyes of test animals. In skin, significant reddening was observed throughout at least day 9. Swelling was perceptible throughout and appeared to become more noticeable with time. Bloody wounds and scar formation were observed through at least observation day 9. The test substance is considered highly irritating to the skin of rabbits. In eyes, LAB Sulfonic Acid was moderately irritating but because of the intensity of the necrosis formation the study was stopped at day 6. According to these results for the read-across source substance, Benzenesulfonic acid, 4-C15-16-sec-alkyl derivs. is classified as CLP category 1C for skin irritation (H314: Causes severe skin burns and eye damage) and CLP category 1 for eye irritation (H318: Causes serious eye damage).
The first key study (Murmann 1984) examined the potential for the read-across source substance to cause dermal irritation/corrosivity. The shaved backs of three male and three female rabbits were exposed for 4 hours to 0.5 ml of the LAB Sulfonic Acid and observed for up to 14 days. Significant reddening was observed throughout at least day 9. Swelling was perceptible throughout and appeared to become more noticeable with time. Bloody wounds and scar formation were observed through at least observation day 9. The test substance is considered a Category 1C corrosive according to CLP guidelines based on persistent irritation (H314: Causes severe skin burns and eye damage).
The second key study (Murmann 1984) also examined the potential of the read-across source substance to cause irritation/corrosivity to eyes. The eyes of six rabbits were treated with LAB Sulfonic Acid and observed for six days. Treatment was to the right eye with lower lid removed. The left eye was untreated and served as the control. The eyes were not washed out during the test. Observations were made at 1, 24, 48, and 72 hours and at 6 days after application. Results indicate that the substance was moderately irritating but because of the intensity of the necrosis formation the study was stopped at day 6. According to these results, the read-across source substance is a category 1 eye irritant according to CLP because it caused damage that was not reversible within the 6 days of the study (H318: Causes serious eye damage).
Effects on skin
irritation/corrosion: highly irritating
Effects on eye irritation: moderately irritating
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.