Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 938-677-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
An OECD TG 201 algal growth inhibition test (Mead, 2000) was performed with potassium zirconium carbonate. Exposure of Scenedesmus subspicatus gave an EbC50 (72h, TWA) value of 0.82 mg/L and an ErC50 (0-72h, TWA extrapolated) value of 17 mg/L. The No Observed Effect Concentration (TWA) was 0.23 mg/L. The preferred observational endpoint for risk assessment in this study is the algal growth rate inhibition of ErC50 (0-72h, TWA) value of 17 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 17 mg/L
Additional information
The toxicity of the test material to aquatic plants was investigated in the algae Scenedesmus subspicatus in accordance with the standardised guidelines OECD 201 and EU Method C.3.
Following a preliminary range-finding study, Scenedesmus subspicatus was exposed to an aqueous solution of the test material at concentrations of 0.50, 1.0, 2.0, 4.0 and 8.0 mg/l (three triplicates per concentration) for 72 hours, under constant illumination and shaking at a temperature of 24 ± 1ºC. Samples of the algal population were removed daily and cell concentrations determined for each control and treatment group, using a Coulter Multisizer II Particle Counter.
Exposure of Scenedesmus subspicatus to the test material gave nominal figures of EC₅₀ (72 h, biomass) value of 1.3 mg/l and an EC₅₀ (0 -72 H, growth) value of 18 mg/l. The No Observed Effect Concentration was 0.50 mg/l.
The zirconium concentration in the test preparations was determined using Inductively Coupled Plasma Atomic Emission Spectroscopy and was then converted to the concentration of test material by multiplying by the appropriate factor. Analysis of the test samples at 0 hours showed the measured test concentrations to range from 42% to 85% of nominal (based on zirconium analysis). At 72 hours the measured test concentrations ranged from 50% to 79% of nominal. The variation in measured concentrations ohof zirconium analysis were considered to be due to one or a combination of: adsorption to algal cells, sampling from a heterogeneous dispersion or an inappropriate method of analysis.
Given the variation obtained in the measured test concentrations at 0 and 72 hours, it was considered justifiable to calculate the results of the study in terms of the time-weighted mean measured test concentrations in order to give a worst case analysis of the data.
In terms of the time-weighted mean measured test concentrations, the EC₅₀ (72 h, biomass) value was determined to be 0.82 mg/l and the EC₅₀ (0 -72 h, growth) value was 17 mg/l. The No Observed Effect Concentration (NOEC) was 0.23 mg/l.
Additional information was supplied by the study sponsor indicating that zirconium salts were extremely efficient at removing phosphates from solution. Therefore it was considered possible that the reduction in algal growth observed in the definitive study was a result of phosphate starvation rather than true test material toxicity. Post study work was therefore conducted where Scenedesmus subspicatus cells were exposed to the test material at concentrations of 0.50, 2.0 and 8.0 mg/l for a period of 72 hours. After the exposure period aliquots of the test cultures were removed, used to inoculate fresh culture medium and the resulting sub-cultures incubated for a period of 96 hours. Regrowth of algal cells occurred in all test cultures after 96 hours thereby indicating that the test material was algistatic in effect. This effect was considered to be due to the test material removing phosphates from solution and hence preventing the algal cells from growing rather than true toxicity of the test material to algal cells.
The study was performed in line with GLP study and accepted standardised guidelines, with a high level of reporting. The study was assigned a reliability score of 1 according to the principles for assessing data quality set out in Klimisch (1997).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.