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EC number: 939-714-0 | CAS number: 1474044-77-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Start : 19 March 2012 Completion : 29 October 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study without deficiencies
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken at t=0 hours and at 5 days. Blank buffer solutions containing a similar content of blank spiking solution were treated similarly as the test samples and analysed at t=0 hours.
- Buffers:
Acetate buffer pH 4, 0.01 M:
solution of 16.7% 0.01 M sodium acetate and 83.3% 0.01 M acetic acid. The buffer contains 0.0009% (w/v) sodium azide.
Phosphate buffer pH 7, 0.01 M:
solution of 0.01 M potassium di-hydrogenphosphate adjusted to pH 7 using 1 N sodium hydroxide. The buffer contains 0.0009% (w/v) sodium azide.
Borate buffer pH 9, 0.01 M:
solution of 0.01 M boric acid and 0.01 M potassium chloride adjusted to pH 9 using 1 N sodium hydroxide. The buffer contains 0.0009% (w/v) sodium azide.- Preliminary study:
At pH 4, pH 7 and pH 9 a degree of hydrolysis of < 10% was observed after 5 days. It demonstrated that the half-life time of the test substance at 25°C is > 1 year. According to the guideline, no further tests were required.
A small test substance peak was detected in the one of blank buffer samples at pH 4. The signal was below the lowest standard (2 μg/l) after a dilution by a factor of 2. Since no test substance was observed in the duplicate sample, it was not considered to derive from the buffer solution.
The mean recoveries of the test substance in the buffer solutions did not fall within the criterion range of 70-110% for non-labelled chemicals. The deviating recoveries are probably related to the low solubility of the test substance in the different buffer solutions. Since a hydrolysis study focuses on the relative concentration decrease of the test substance in time, the mean recoveries were considered acceptable and the analytical method was considered adequate for the support of the hydrolysis study on the test substance.- Transformation products:
- not measured
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Conclusions:
The preliminary test (Tier 1) was performed for the determination of the rate of hydrolysis of
di C8-C10, branched, C9 rich, alkylnaphthalene sulphonic acid (DNNSA) at pH values normally found in the environment (pH 4-9).
At each pH value a degree of hydrolysis of < 10% was observed after 5 days. According to the guideline, performance of the main study (Tier 2) was not required.
The half-life time of the test substance at 25°C was:
t½ pH 4: > 1 year
pH 7 > 1 year
pH 9 > 1 year- Executive summary:
The rate of hydrolysis of di C8-C10, branched, C9 rich, alkylnaphthalene sulphonic acid (DNNSA) as a function of pH was determined at pH values normally found in the environment (pH 4-9). A high performance liquid chromatographic method with tandem mass spectrometric detection (HPLC-MS/MS) for the quantitative analysis of the test substance in water was developed and employed in the assessment. For a Preliminary test, the buffer solutions were filter-sterilised through a 0.2 μm FP 30/0.2 CA-S filter (Whatman, Dassel, Germany) and transferred into a sterile vessel. To exclude oxygen, nitrogen gas was purged through the solution for 5 minutes. The test substance was spiked to the solutions at a target concentration of 50 μg/l using a spiking solution in acetonitrile. For each sampling time, duplicate sterile vessels under vacuum were filled with 6 ml test solution and placed in the dark in a temperature controlled environment at 49.9°C ± 0.1°C.
The concentration of the test substance in the test samples was determined immediately after preparation (t=0) and after 5 days. The samples taken at t=5 days were cooled to room temperature using running tap water. The samples were diluted in a 1:1 (v:v) ratio with acetonitrile and analysed.
Blank buffer solutions containing a similar content of blank spiking solution were treated similarly as the test samples and analysed at t=0.
The pH of each of the test solutions (except for the blanks) was determined at each sampling time.
At pH 4, pH 7 and pH 9 a degree of hydrolysis of < 10% was observed after 5 days. It demonstrated that the half-life time of the test substance at 25°C is > 1 year. According to the guideline, no further tests were required.
A small test substance peak was detected in the one of blank buffer samples at pH 4. The signal was below the lowest standard (2 μg/l) after a dilution by a factor of 2. Since no test substance was observed in the duplicate sample, it was not considered to derive from the buffer solution.
The mean recoveries of the test substance in the buffer solutions did not fall within the criterion range of 70-110% for non-labelled chemicals. The deviating recoveries are probably related to the low solubility of the test substance in the different buffer solutions. Since a hydrolysis study focuses on the relative concentration decrease of the test substance in time, the mean recoveries were considered acceptable and the analytical method was considered adequate for the support of the hydrolysis study on the test substance.
The half-life time of DNNSA at 25°C was:
t½ pH 4: > 1 year
pH 7 > 1 year
pH 9 > 1 year
Reference
Preliminary test – hydrolysis of DNNSA at pH 4, pH 7 and pH 9
pH |
Sampling time |
Analyzed Concentration μg/L |
% Hydrolysis Individual |
% Hydrolysis Mean |
4 |
0 hours |
28.0, 26.2 |
|
|
|
5 days |
30.6, 24.9 |
-13, 8.1 |
-2.5 |
7 |
0 hours |
66.3, 77.5 |
|
|
|
5 days |
65.3, 64.1 |
1.6, 3.4 |
2.5 |
9 |
0 hours |
26.9, 27.5 |
|
|
|
5 days |
27.8, 25.6 |
-2.3, 6.0 |
1.9 |
Description of key information
A preliminary test (Tier 1) was performed for the determination of the rate of hydrolysis of di C8-C10, branched, C9 rich, alkylnaphthalene sulphonic acid (DNNSA) at pH values normally found in the environment (pH 4-9). At each pH value a degree of hydrolysis of < 10% was observed after 5 days. According to the guideline, performance of the main study (Tier 2) was not required.
The half-life time of the test substance at 25°C is > 1 year at the pHs tested.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
The half-life time of the test substance at 25°C was:
t½ pH 4: > 1 year
t½ p H 7 > 1 year
t½ pH 9 > 1 year
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