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EC number: 692-731-2 | CAS number: 76950-43-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 - 20 Feb 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Water samples were taken for quantitative analysis at the start and end of exposure (one sample was analyzed in duplicate, mean value was determined).
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 4 L of culture water (areated before preparation) was taken and filtered through with a membrane filter (8.0 µm). 0.2 g of test substanc (adapted to purity) was weighted and diuted to 200 mL test water to prepare 1000 mg/L stock solution. 100 mL of stock solution was diluted in a 1 L flask to prepare 100 mg/L test solution
- Eluate: no
- Differential loading: yes
- Controls: Culture water without test substance - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: National Institute for Environmental Studies
- Lot: DM-1101
- Age at study initiation: < 24 hours
- Feeding during test: none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Test temperature:
- 19.5 - 19.9 °C
- pH:
- 8.11 - 8.98
- Dissolved oxygen:
- 7.6 - 7.9 mg/L
- Nominal and measured concentrations:
- nominal: control, 100 mg/L
measured: < LOD, 91.3 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beaker, covered with glass petri dish
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Tap water was filtered through a PF filter, thereafter through an activated charcoal filter and again through a PF filter. Measurement values (like hardness, particulate matter, pH-value, total organic carbon, etc.) were confirmed within the range of values according to 'Water Quality Criteria for Fisheries' (Japan Fisheries Resource Conservation Association, March, 2006), OECD 210 and Health and Welfare Ministry ordinance No. 101, January 28 2011
- Intervals of water quality measurement: More than once every six month
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light / 8 h dark (room light)
TEST CONCENTRATIONS
- Range finding study: yes
- Test concentrations: nominal test concentrations of 10 and 100 mg/L
- Results used to determine the conditions for the definitive study: No mortality was observed in both concentrations - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 91.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Behavioural abnormalities: No abnormal behaviour in control and test concentration.
- Mortality of control: none - Results with reference substance (positive control):
- The result of the test with the standard substance (performed in February, 2014) was within the normal range in this laboratory (48 hour-EC50 = 0.57 mg/L).
- Validity criteria fulfilled:
- yes
Reference
Table 1: Immobilisation of Daphnia magna
Nominal (measured) concentration (mg/L) |
Immobilised Daphnia (%) |
|
24 hours |
48 hours |
|
Control |
0 |
0 |
100 (91.3) |
0 |
0 |
Description of key information
LC50 (48 h): > 100 mg/L (nominal) for Daphnia magna (OECD 202)
LC50 (48 h): > 91.3 mg/L (nominal) for Daphnia magna (OECD 202)
Key value for chemical safety assessment
Additional information
One experimental study investigating the short-term effects of the test substance to aquatic invertebrates is available (Tosoh Corporation, 2014). The study was performed according to OECD 202 under GLP conditions with the water flea Daphnia magna. The limit test with the test concentration of 100 mg/L (nominal) did not result in any immobilized Daphnia and no abnormal behavior was observed. Thus, EC50 values (48 h) of > 100 mg/L (nominal) and > 91.3 mg/L (measured) were derived.
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