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Diss Factsheets
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EC number: 692-731-2 | CAS number: 76950-43-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 Apr - 24 May 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with acceptable restrictions (no detailed information on composition of inoculum)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: Purchased from Chemicals Evaluation and Research Institute, Japan, on April 14, 2011 (sludge no. 230414)
- Laboratory culture: Cultured under 25 ± 2 °C, not less than 5 mg/L of dissolved oxygen concentration and pH 7.0 ± 1.0
- Concentration of sludge: 4647 mg/L (25 Apr 2011) - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: recommended medium in the guideline
- Test temperature: 25.0 °C
- Suspended solids concentration: 30 mg/L
- pH at the end of exposure: in the samples sludge + test substance: 7.18 – 7.39, in the sample water + test substance: 8.86
TEST SYSTEM
- Culturing apparatus: Coulometer Type OM-2001A, Ohkura Electric Co., Ltd.
- Number of culture flasks/concentration: 3 (sludge + test sub.)
- Measuring equipment: Coulometer
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 1 replicate
- Abiotic sterile control: no
- Toxicity control: no
- Reference substance: yes, 1 replicate - Reference substance:
- aniline
- Remarks:
- 100 mg/L
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2
- Sampling time:
- 28 d
- Remarks on result:
- other: Mean of three replicates
- Results with reference substance:
- Degradation of aniline: 67% and 74% degradation after 7 days and 14 days, respectively; 60% pass level was reached.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
Reference
Table 1: Residual rate and degradation rate
Results of |
Test solution |
Residual rate (%) |
Degradation rate (%) |
BOD |
Sludge + test substance |
- |
2 * |
Determination of 1,4-isomer (GC) |
Sludge + test substance |
99 * |
6 * |
Water + test substance |
105 |
- |
|
Determination of 1,5-isomer (GC) |
Sludge + test substance |
100 * |
0 * |
Water + test substance |
100 |
- |
* mean values
Table 2: Residual amount of TOC
Test solution |
Residual amount of TOC (1) |
Residual rate (%) |
Degradation rate (%) |
Sludge + test substance |
18.9 * |
106 * |
2 * |
Water + test substance |
19.2 |
108 |
- |
* mean values
(1) Calculation by subtracting control blank from sludge + test substance, and water blank from water + test substance, respectively
Description of key information
Under test conditions no biodegradation observed: 2% after 28 d based on O2 consumption (OECD 301C)
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
One study is available investigating the ready biodegradability of the test substance. The study was performed according to OECD 301C under GLP conditions using a mixed population of activated sewage sludge microorganisms (Tosoh Corporation, 2011). A biodegradation of 2% based on O2 consumption was attained after 28 d indicating that the substance is not readily biodegradable under the test conditions. The toxicity control attained 67% degradation after 7 d and 74% after 28 d indicating that the test substance is not inhibitory to the inoculum. In conclusion the test substance is not readily biodegradable according to the OECD criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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