Registration Dossier
Registration Dossier
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EC number: 936-349-9 | CAS number: 1312304-36-1
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EU/OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate
- Cas Number:
- 1312304-36-1
- Molecular formula:
- C11H12ClN3O4
- IUPAC Name:
- methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Duration of test (contact time):
- > 21 - < 23 h
Initial test substance concentration
- Initial conc.:
- 100 mg/L
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 22
- Sampling time:
- 28 d
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: The test item is considered to be "Not Readily Biodegradable".
- Conclusions:
- All validity criteria of the test method were met:
The reference compound reached the level of ≥ 60 percent for ready biodegradability within 14 days .
The toxicity control exhibited degradation rates > 25 % within 14 days (table 5).
At the end of the test, at the plateau, or the end of the 10-d window, biodegradation in parallels with test item did not differ by more than 20 percentage points .
The oxygen uptake of the inoculum blank was ≤ 60 mg/L .
In cases where the degradation was ≤ 60 %, the pH values were in between 6.0 and 8.5 at the end of the test. - Executive summary:
Within 28 days, a degradation rate of 22 % was determined for the test item.
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