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Diss Factsheets
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EC number: 916-914-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity: via oral route
The LD50 of TK 12871 was greater than 5,000 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From March 11, 1981 to March 27, 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Principles of method if other than guideline:
- Toxicity rating according to company standards
highly toxic LD50: < 50 mg/kg
toxic LD50: 50 - 300 mg/kg
moderately toxic LD50: 300 - 500 mg/kg
slightly toxic LD50: 500 - 5000 mg/kg
practically non toxic LD50: >5000 mg/kg - GLP compliance:
- yes
- Species:
- rat
- Strain:
- other: Tif:RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age at study initiation: 7 to 8 week old
- Water: ad libitum
- Acclimation period: at least 4 days
- Temperature (°C): 22 ± 2 °C
- Humidity (%): 50 ± 10%
- Photoperiod: 10-hrs light per day - Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- For male: five
For female: five - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to company standards, TK 12871 was practically non- toxic to the rat by this route of administration. Therefore, TK 12871 was not met a category based on GHS criteria.
- Executive summary:
This test using the procedures outlined in the CIBA-GEIGY Limited for 810281. A total of 5 male and 5 female Tif:RAIf (SPF) rats were orally dosed with TK 12871, at 5000 mg/kg. The animals recovered within 7 days. All animals were submitted to a necropsy, at the end of the observation period. No gross organ changes were observed. The LD50 of TK 12871 was greater than 5,000 mg/kg. Therefore, the test material is practically non- toxic to the rat by this route of administration.
Reference
Signs and symptoms: The animals recovered within 7 days. All animals were submitted to a necropsy, at the end of the observation period.
Autopsies: No gross organ changes were observed.
Table 1. Rate of deaths
Dose mg/kg |
Sex |
Total Number animals in group |
Total Number animals dead |
Death rate percentage |
5000 |
♂ |
5 |
0 |
0 |
5000 |
♀ |
5 |
0 |
0 |
Table 2. Body weights
Dose mg/kg |
Body weights (g) ± Standard Deviation |
|||||
Male |
Female |
|||||
Day 1 |
Day 7 |
Day 14 |
Day 1 |
Day 7 |
Day 14 |
|
5000 |
182±4.3 |
223±11.8 |
249±5.0 |
171±5.03 |
201±9.0 |
217±10.5 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute toxicity: via oral route
A total of 5 male and 5 female Tif:RAIf (SPF) rats were orally dosed with TK 12871, at 5000 mg/kg. The animals recovered within 7 days. All animals were submitted to a necropsy, at the end of the observation period. No gross organ changes were observed. The LD50 of TK 12871 was greater than 5,000 mg/kg. Therefore, the test material is practically non-toxic to the rat by this route of administration.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.