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Diss Factsheets
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EC number: 604-269-0 | CAS number: 14205-46-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
Category Approach for three different 3-aminocrotonic acid esters
Testsystem
-
(CAS-No. 14205-39-1)
- Isopropylester
(CAS-No. 14205-46-0)
- Isobutylester
(CAS-No. 52937-90-3)
Akut oral
Classification with R 22/ Acute Tox 4
LD50:1760 mg/kg
Results: 1300 mg without findings,
¿1500 narcosis, cyanosis, etc.;
irritation in the stomach mucosa
(Bayer internal report: Löser, 1983-06-30, T2015646)
No classification
LD50: > 2000 mg/kg
Results: limit dose study; piloerection and diuresis up to 48 h after dosing
(Bayer internal report: Bomhard, 1989-03-01, No. 17779)
Classification with R 22 / Acute Tox 4
LD50:1400 mg/kg
Results: 1000 mg without findings,
¿1300 mortality; narcosis, cyanosis, etc.
irritation in the stomach mucosa
(Bayer internal report: Ramm, 1985-11-12, No. T0020251)
Akut inh.
LC50 > 23 mg/m³ (dust; maximal technically feasible concentration)
(Bayer internal report: Pauluhn, 1983-04-27, No. 11752)
>6064 mg/m³ (aerosol)
(Bayer internal report: Pauluhn, 1989-06-20, No. 18104)
No data
Skin irritation
No classification
Bayer report: Slight skin irritation (erythema grade 2, 24h; grade 1, 48h)
Lonza report: No skin irritation
(Bayer internal report: Schmidt, 1983-08-04, T5045748)
No classification
Slight skin irritation (erythema 0.3-1.0)
(Bayer internal report: Märtins, 1989-03-20, No. 17843)
No classification
No data available
Slight irritation expeced via category approach
Eye irritation
Classification with R 41/ Eye Damage 1
Bayer report: Slight irritation (mean: cornea 0.3-0.7; erythema 1.3-2.0; chemosis 1.3-2.3)
Lonza report: 1 animal with cornea grade 2 not reversible; animal 2 and 3: slight
(Bayer internal report: Schmidt, 1983-08-03, T6015767)
(Lonza report: Donald, 2000-03-23, No. 3202)
Classification with R 36 / Eye Damage 2
Cornea grade 1-2, erythema grade 1-2, reversible
(Bayer internal report: Märtins, 1989-03-20, No. 17843)
Classification with R 36 / Eye Damage 2
No data available
Eye irritation expeced via category aproach
Skin sensi
Classification with R 43 / Skin sens 1 B
Bayer report: M&K neg (paraffin; 5%, 12%, 1%; 1.challenge 3/10, 2. 1/10)
Lonza report: M&K positive (maize oil, induction max. practicable conc.; challenge: max non-irritant conc. ; 4%, 60%, 60%; 10/10);
QSAR toolbox predicts moderate skin sensitization potential (via Michael addition)
(Bayer internal report: Stropp, 1997-08-07, No. 26525)
(Lonza report: Donald, 2000-03-23, No. 3204)
Classification with R 43/ Skin sens 1 B
No animal data available
QSAR toolbox predicts moderate skin sensitization potential (via Michael addition)
Moderate skin sensitizing potential expected via category approach and QSAR
Classification with R 43 / Skin sens 1 B
No animal data available
QSAR toolbox predicts moderate skin sensitization potential (via Michael addition)
Moderate skin sensitizing potential expected via category approach and QSAR
Ames Test
(4 Salmonella strains)
No classification
Negativ
(Bayer internal report: Herbold, 1986-01-07, No. 14189)
No classification
Negativ
(Bayer internal report: Herbold, 1990-08-08, No. 19390 plus Amendment of 1994)
No classification
Negativ
(Bayer internal report: Herbold, 1986-04-01, No. 14493)
In vivo mouse bone marrow MNT
No data
Negativ
(Bayer internal report: Herbold, 1990-05-29, No. 19096 plus Amendment of 1994)
No data
Justification for classification or non-classification
Based on a category approach with three different 3 -aminocrotonic acid esters, 3 -aminocrotonic acid propyl ester should be classified as skin sensitizer with Xi, R43 according to Directive 67/548/EEC. According to Regulation (EC) No. 1272/2008 (CLP) and the amending Regulation (EC) No. 286/2011, the substance should be classified as skin sensitizer Category 1B (H317).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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