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EC number: 600-520-3 | CAS number: 1040874-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 27, 1995
- Deviations:
- yes
- Remarks:
- For the determination of water solubility about three times the quantity of Test Item necessary to saturate the desired volume of water was applied. This part of the study deviates from the guideline.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 19 March 2014
- Deviations:
- yes
- Remarks:
- For the determination of water solubility about three times the quantity of Test Item necessary to saturate the desired volume of water was applied. This part of the study deviates from the guideline.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- yes
- Remarks:
- For the determination of water solubility about three times the quantity of Test Item necessary to saturate the desired volume of water was applied. This part of the study deviates from the guideline.
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- Date of production: 31 May 2017
Expiration date: 31 May 2022 - Key result
- Water solubility:
- 13.5 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 10.14 - <= 10.16
- Conclusions:
- The water solubility of the test item was determined to be 13.5 g/L at 20 ± 1 °C using the shake-flask method according to OECD TG 105.
- Executive summary:
The water solubility of the test item was determined according to OECD TG 105, EU Method A.6 and EPA OPPTS 830.7840 (Water Solubility) to be 13.5 g/L at 20 ± 1 °C using the shake-flask method for the performance.
Reference
Results of the Method Validation
Measurement repeatability |
CV% < 1 % |
Repeatability of the Preparation (n=5/4) |
CV% < 1.5 % |
Linear range |
0.5 - 100 µg/mL |
Correlation coefficients |
> 0.999 |
Limit of Quantification |
0.5 µg/mL |
Limit of Detection |
0.2 µg/mL |
Recovery from ISO medium |
94 % |
Recovery from20X AAPmedium |
90 % |
Recovery from ultra-pure water (1 g/L) |
101 % |
Recovery from ultra-pure water (12 g/L 15 g/L)* |
99 % 88 % |
Accuracy(samples used for calibration) |
≤ 3 % |
Precision |
≤ 5 % |
Stability of the test item in ISO medium at the temperature 18-22 °C for 2 days |
stable |
Stability of the test item in 20X AAP medium at the temperature 22-26 °C for 7 days |
43 % |
Stock solution stability (0.2 mg/ml) |
stable |
* performed in this study
Results of the determination of test item concentrations
Sampling time |
Measured concentration of test item (g/L) |
Measured pH |
||
Test vessels |
Mean with the 95% confidence intervals |
|||
After 24h |
13.7 |
13.5 ± 0.35 |
10.14 |
|
13.5 |
10.15 |
|||
13.4 |
10.14 |
|||
After 48h |
13.4 |
13.4 ± 0.13 |
10.15 |
|
13.5 |
10.15 |
|||
13.4 |
10.14 |
|||
After 72h |
13.5 |
13.6 ± 0.67 |
10.16 |
|
13.3 |
10.15 |
|||
13.9 |
10.15 |
|||
Solubility ofthe test item (g/L) |
13.5 ± 0.14 |
- |
||
RSD% |
0.4 |
- |
||
pH of ultra-pure water |
- |
~7 |
Description of key information
The water solubility of the test item was determined to be 13.5 g/L at 20 ± 1 °C using the shake-flask method according to OECD TG 105 and EU Method A.6.
Key value for chemical safety assessment
- Water solubility:
- 13.5 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined according to OECD TG 105, EU Method A.6 and EPA OPPTS 830.7840 (Water Solubility) to be 13.5 g/L at 20 ± 1 °C using the shake-flask method for the performance.
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