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5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octahydroxy-2λ⁶,8λ⁶,14λ⁶,20λ⁶,26λ⁶,32λ⁶,38λ⁶,44λ⁶-octathianonacyclo[43.3.1.1³,⁷.1⁹,¹³.1¹⁵,¹⁹.1²¹,²⁵.1²⁷,³¹.1³³,³⁷.1³⁹,⁴³]hexapentaconta-1(49),3,5,7(56),9,11,13(55),15,17,19(54),21(53),22,24,27,29,31(52),33,35,37(51),39(50),40,42,45,47-tetracosaene-2,2,8,8,14,14,20,20,26,26,32,32,38,38,44,44-hexadecone; 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrahydroxy-2λ⁶,8λ⁶,14λ⁶,20λ⁶-tetrathiapentacyclo[19.3.1.1³,⁷.1⁹,¹³.1¹⁵,¹⁹]octacosa-1(25),3,5,7(28),9,11,13(27),15(26),16,18,21,23-dodecaen-2,2,8,8,14,14,20,20-octone
EC number: 481-490-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 September 2007 (start) - 23 October 2007 (end)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to OECD and EC guidelines and according to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 481-490-7
- EC Name:
- -
- Molecular formula:
- multi-constituent.
- IUPAC Name:
- 5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octahydroxy-2λ⁶,8λ⁶,14λ⁶,20λ⁶,26λ⁶,32λ⁶,38λ⁶,44λ⁶-octathianonacyclo[43.3.1.1³,⁷.1⁹,¹³.1¹⁵,¹⁹.1²¹,²⁵.1²⁷,³¹.1³³,³⁷.1³⁹,⁴³]hexapentaconta-1(49),3,5,7(56),9,11,13(55),15,17,19(54),21(53),22,24,27,29,31(52),33,35,37(51),39(50),40,42,45,47-tetracosaene-2,2,8,8,14,14,20,20,26,26,32,32,38,38,44,44-hexadecone; 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrahydroxy-2λ⁶,8λ⁶,14λ⁶,20λ⁶-tetrathiapentacyclo[19.3.1.1³,⁷.1⁹,¹³.1¹⁵,¹⁹]octacosa-1(25),3,5,7(28),9,11,13(27),15(26),16,18,21,23-dodecaen-2,2,8,8,14,14,20,20-octone
- Reference substance name:
- MIxture of TC4A-SO2 and TC8A-SO2
- IUPAC Name:
- MIxture of TC4A-SO2 and TC8A-SO2
- Details on test material:
- - Name of test material (as cited in study report): mixture of TC4A-SO2 and TC8A-SO2
- Substance type: multi-constituent
- Physical state: solid
- Stability under test conditions: Stable under storage conditions. There was no difference between the IR spectrum taken at the start of the study and after completion of the study.
- Storage condition of test material: in the archives of the room where the test substance is handled.
- Other: The IR spectrum of the test substance was shown to be similar to that supplied by the study sponsor, confirming the identity.
Constituent 1
Constituent 2
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial (adaptation not specified)
- Details on inoculum:
- Source:
Standard activated sludge, purchased from Chemicals Evaluation and Research Institute Japan, Chemical Biotesting Center, Tokyo Japan.
Preparation inoculum:
After ceasing aeration of the sludge mixture for 30 minutes, container was left still for the gravity sedimentation of sludge particles. 300 ml supernatant was removed and 300 ml synthetic sewage was added to the mixture and the container was aerated again. The pH was kept at 7.0 +/- 1.0 .
Synthetic sewage: glucose, peptone and potassium phosphate monobasic were dissolved in dechlorinated water to obtain 0.1% (w/v) of each component and pH was adjusted with 0.1 M sodium hydroxide to 7.0 +/- 1.0. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimationopen allclose all
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Remarks:
- HPLC
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- BOD
- Details on study design:
- PREPARATION OF TEST SOLUTION:
Basal culture medium: In accordance with "Test methods of industrial liquid waste" (JIS K 0102-1998-21). In purified water adjusted to pH 7.2.
The concentration of suspended solid of the cultivated activated sludge was 3800 mg/L. The cultivated activated sludge was diluted with a standard medium so as to make the sludge concentration of 900 mg/L.
Vessel 1 (water degradation test group): 300 ml of water and 30 mg of test substance (100 mg/l)
Vessel 2 (inoculum blank): 290 ml of basal culture medium
Vessel 3 (reference group): 290 ml of basal culture medium and 30 mg of aniline
Vessels 4, 5 and 6 (biodegradation test group): 290 ml of basal culture medium and 30 mg of test substance
10 ml of the diluted cultivated activated sludge was inoculated to the vessels 2, 3 and 4, 5, 6 : volume total in test vessel: 300 mL. Suspended solid concentration: 30 mg/L.
INCUBATION CONDITIONS:
Temperature: 25 +/- 1 deg C
Incubation time: 28 days
Light conditions: Light-shielded (except during the additions and the observations)
BIOCHEMICAL OXYGEN DEMAND (BOD) CONDITIONS:
Closed system oxygen consumption measuring apparatus
Absorbent for carbon dioxide: Soda Lime
The test solutions were stirred by a magnetic stirer.
It was confirmed that there was no leakage in the closed system before the BOD measurement.
MEASUREMENTS:
As the test substance is a mixture of 2 components, the amount of residual test substance was calculated not only as a sum of 2 components but also for each component (TC4A-SO2 and TC8A-SO2).
CALCULATIONS:
The percentage biodegradation by BOD as well as by HPLC were calculated.
STATISTICAL METHODS:
Reference substance
- Reference substance:
- aniline
Results and discussion
- Preliminary study:
- Not performed.
- Test performance:
- Appearance test solution (sludge + test substance) after incubation: Not dissolved. No growth of sludge. No coloration.
The pH of the test solution after incubation was 7.93 (water+test substance) and 7.02, 7.08 and 7.10 in the solutions containing sludge + test substance.
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- -8
- Sampling time:
- 28 d
- Remarks on result:
- other: BOD
- Parameter:
- % degradation (test mat. analysis)
- Value:
- -2
- Sampling time:
- 28 d
- Details on results:
- HPLC: -2% based on both components. -2% and 0% based on the individual components (TC4A-SO2 and TC8A-SO2, resp.)
BOD5 / COD results
- Results with reference substance:
- The percentage biodegradation of the reference substance after 14 days was 76% , which is higher than 60%.
Any other information on results incl. tables
Since the mean degree of degradation by BOD and by HPLC (sum of 2 components) was -8% and -2%, respectively, the test substance was considered to be persistent.
Analytical results confirmed that the composition of the test substance was not changed.
The residual percentage (concentration analysed relative to the concentration formulated) was 98 -100% for all test solutions containing test substance.
The difference between the maximum value and the minimum value for degradation of the test substance at the end of the test was 1% for the degradation determined from the BOD and 0-2% for the degradation determined by HPLC, both of which were less than 20%.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
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