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EC number: 262-634-6 | CAS number: 61167-58-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Non-GLP guideline study without analytical measurements.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- Adopted: 13 April 2004
- GLP compliance:
- no
- Remarks:
- The study was not conducted in accordance with GLP since it was originally used for screening purposes of environmental hazards at the manufacturing plant.
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test solution was prepared as water accommodated fraction (WAF) referred to OECD Guidance Document No. 23: 100.6 mg of the test substance was dissolved with the dilution water to make volume to 1000 mL, stirred with a magnetic stirrer for 48 h at the test temperature and then left at rest for 1 hour. Almost all of the test substance was floating on the water surface and partially observed on the bottom of vessel or intermediate water. Finally the test solution was prepared by vacuum filtration with 0.45 μm membrane filter (Mixed Cellulose Ester, Advantec Toyo Kaisha, Ltd.). The test solution used for water exchange at 24 hour after initiation of exposure was also prepared independently under the same condition. Appearance of the test solutions was recorded just after preparation.
- Eluate: no
- Differential loading: no
- Controls: yes, test medium control - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: Originally obtained from National Institute for Environmental Studies, Japan (28 Oct 1996)
- Feeding during test: none
- Age: < 24 h
ACCLIMATION
- Acclimation period: 01 - 16 Mar 2016
- Acclimation conditions: The parents indicated good reproductive conditions, since no sign of abnormality such as production of ephippia was observed.
- Type and amount of food: Commercial condensed live Chlorella and YCT (yeast, dried alfalfa and Tetramin); 0.1 – 0.2 mg C (organic carbon) / daphnid / day
- Feeding frequency: daily
- Health during acclimation (any mortality observed): Mortality of the parent daphnids during the acclimation period was 0%. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg/L as CaCO3
- Test temperature:
- 20.1 - 20.3 °C
- pH:
- 7.7 - 7.9
- Dissolved oxygen:
- 8.7 - 8.8 mg O2/L
- Nominal and measured concentrations:
- nominal: control, 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL volume glass beaker
- Type (delete if not applicable): covered with a transparent plastic lid
- Aeration: no
- Renewal rate of test solution (frequency/flow rate): every 24 h
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 16 daphnids/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Artificial reconstituted water, Elendt M4
- Culture medium different from test medium: same as test
- Intervals of water quality measurement: Water quality was measured regularly.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light / 8 h darkness
- Light intensity: Room lighting (5.00 – 9.96 μE/m²/s), 16 h light / 8 h dark cycle
EFFECT PARAMETERS MEASURED
- Number of immobilized daphnids and other toxic symptoms compared to the control were recorded at 24 and 48 h after initiation of exposure - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (tested regularly)
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Other biological observations: No other biological effects were recorded.
- Mortality of control: 0%
- Other adverse effects control: No other adverse effects were recorded. - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: EC50 (48 h): 0.99 mg/L (Study termination date: 25 Feb 2016) - Reported statistics and error estimates:
- No statistical analysis was necessary since no effects on fish were observed.
- Validity criteria fulfilled:
- yes
- Remarks:
- For further details please refer to “Any other information on results incl. tables”.
Reference
Table 1: Validity criteria
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
In the control, including the control containing the solubilising agent, not more that 10% of the daphnids should have been immobilized. |
0% |
yes |
The dissolved oxygen concentration at the end of the test should be ≥ 3 mg/L in control and test vessels. |
8.7 - 8.8 mg/L |
yes |
Description of key information
EC50 (48 h) > 100 mg/L (nominal, Daphnia magna, OECD 202)
Key value for chemical safety assessment
Additional information
One experimental study is available investigating the toxicity of 2-(1,1-dimethylethyl)-6-[[3-(1,1-dimethylethyl)-2-hydroxy-5-methylphenyl]methyl]-4-methylphenyl acrylate (CAS 61167-58-6) to the freshwater invertebrate Daphnia magna. The study was performed according to OECD 202 (non-GLP) as a limit test with a filtered test solution of 100 mg/L under semi-static conditions. An appropriate amount of the test item was added to test medium followed by a two day stirring period. Almost all of the test substance was floating on the water surface and partially observed on the bottom of vessel or intermediate water. Finally the test solution was prepared by vacuum filtration with 0.45 μm membrane filter. After this additional step the test solutions were clear and colorless. In this study no analytical verification of the test item concentrations was performed. However, since the preparation of test solutions is nearly comparable to the one in the available short-term study with fish it is assumed that the measured concentrations in test medium will be in a comparable range. After 48 h no immobilization was recorded and the EC50 (48 h) was reported as > 100 mg/L (nominal). All validity criteria of the study are met.
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