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Diss Factsheets
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EC number: 248-374-6 | CAS number: 27253-32-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: short-term inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Conducted to a reasonable scientific standard
Data source
Reference
- Reference Type:
- publication
- Title:
- Oxidative Stress Is Induced in the Rat Brain Following Repeated Inhalation Exposure to Manganese Sulfate
- Author:
- Dobson A, Weber S, Dorman D, Lash L, Erikson K & Aschner M
- Year:
- 2 003
- Bibliographic source:
- Biological Trace Element Research, 93: 113-125.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Eight week old male rats inhaled manganese (Mn) in the form of MnSO4 at 0.0, 0.03, 0.3 or 3.0 mg Mn/m3 for 6 hours per day for 14 consecutive days.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- manganese sulphate
- IUPAC Name:
- manganese sulphate
- Reference substance name:
- Manganese sulphate
- EC Number:
- 232-089-9
- EC Name:
- Manganese sulphate
- IUPAC Name:
- 232-089-9
- Reference substance name:
- 7785-87-7
- Cas Number:
- 7785-87-7
- Molecular formula:
- MnSO4
- IUPAC Name:
- 7785-87-7
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- other:
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: dust
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 14 consecutive days
- Frequency of treatment:
- 6 hours per day
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.092 mg MnSO4/m3 (0.03 mg Mn/m3)
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
0.92 mg MnSO4/m3 (0.3 mg Mn/m3)
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
9.2 mg MnSO4/m3 (3 mg Mn/m3)
Basis:
analytical conc.
- No. of animals per sex per dose:
- Not reported
- Control animals:
- yes, concurrent no treatment
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- other: Increase in glutamine synthetase protein level in olfactory bulbs
- Effect level:
- 0.3 mg/m³ air
- Based on:
- other: Mn2+ content
- Sex:
- male
- Basis for effect level:
- other: overall effects neurochemistry;
- Remarks on result:
- other:
- Dose descriptor:
- other: Increase in glutamine synthetase protein level in hypothalamus
- Effect level:
- 0.03 mg/m³ air (analytical)
- Based on:
- other: Mn2+ content
- Sex:
- male
- Basis for effect level:
- other: overall effects neurochemistry
- Remarks on result:
- other:
- Dose descriptor:
- other: Decrease in glutamine synthetase protein level in cerebellum
- Effect level:
- 3 mg/m³ air (analytical)
- Based on:
- other: Mn2+ content
- Sex:
- male
- Basis for effect level:
- other: overall effects neurochemistry
- Remarks on result:
- other:
- Dose descriptor:
- other: Decrease in total glutathione levels in the hypothalamus
- Effect level:
- 3 mg/m³ air (analytical)
- Based on:
- other: Mn2+ content
- Sex:
- male
- Basis for effect level:
- other: overall effects neurochemistry
- Remarks on result:
- other:
Any other information on results incl. tables
Areas where significant increases in glutamine synthetase protein levels were observed:
Olfactory bulbs at 0.3 mg Mn /m3 air
Hypothalamus at 0.03 mg Mn/m3 air
Significant decrease in glutamine syhthetase protein observed in the cerebellum at 3 mg Mn/m3..
Significant decrease in total glutathione levels observed in the hypothalamus at 3 mg Mn/m3.
Applicant's summary and conclusion
- Conclusions:
- It cannot be unequivocally stated that the data supports the ability of MnSO4 to induce oxidative stress in the hypothalamus. The relevance of the findings to primates has yet to be determined. The lack of changes in any of the measured changes in the striatum indicates that MnSO4 inhalation, even at very high doses, does not induce oxidative stress in this brain region.
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