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EC number: 247-988-1 | CAS number: 26762-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There is no experimental data on toxicokinetic.
Absorption
Diisopropylbenzene hydroperoxide has a molecular weight of 194.3 g/mol, a moderate solubility in water (624 mg/L at 20°C), an experimental log Ko/w of 3.1 and a vapour pressure of 6.7 hPa at 25 °C.It was not shown to be significantly hydrolysed even at pH 1.2/37 °C (half-life: 28.2 hours), therefore following oral/inhalation/dermal route, it is expected to be absorbed unchanged.
Oral absorption is favoured for molecular weights below 500 g/mol. Based on the moderate log Ko/w of 3.1, diisopropylbenzene hydroperoxide can be regarded as a moderately lipophilic substance. Such a lipophilic compound may be taken up by micellular solubilisation. Using a model to predict either high or low fraction absorbed for an orally administered, passively transported substance, the rates of absorption were 100 and 95% for a dose of 1 and 1000 mg of peroxide, respectively (Danish QSAR database).
Based on the moderate vapour pressure of 5 hPa at 25 °C, inhalation exposure is likely. As Luperox DH is a mixture of diisopropylbenzene hydroperoxide in diisopropylbenzene, with other diisopropylbenzene oxidation by-products, this vapor pressure is a worth case figure, representing mostly the impurities vapor pressure.
Similarly, diisopropylbenzene hydroperoxide is likely to penetrate skin regarding the moderate logKo/w value and water solubility. Between water solubility of 100-1000 mg/l absorption is anticipated to be moderate to high. Furthermore, application of Luperox DH to skin of rabbits was responsible of corrosive effects, which could increase the dermal uptake.
The dermal absorption of diisopropylbenzene hydroperoxide was estimated with IH SkinPerm v2.04 model (AIHA, 2018). Compared to in vitro data from OECD 428 studies, IH skinPerm allowed the estimation of the dermal absorption rate with a good confidence and a low frequency (ca. 2%) of underestimation for liquids (Arkema’s internal validation study, 2018). According to the data input, IH SkinPerm v2.04 model leads to the following results:
|
Instantaneous deposition End time observation 8 hr |
Deposition over time End time observation 8 hr |
Total deposition (mg) |
1000 |
8000 |
Fraction in stratum corneum (%) |
9.5 |
4.8 |
Fraction in viable epidermis (%) |
31.4 |
3.9 |
Absorbable fraction (%) |
40.9 |
8.7 |
Lag time stratum corneum (min) |
12.1 |
|
Max. derm. abs. (mg/cm²/h) |
0.0197 |
Therefore, according to the REACH Guidance, default values of 100, 50 and 100% will be used for oral, dermal and inhalation absorptions of diisopropylbenzene hydroperoxide, respectively.
Metabolism and excretion:
There is no data on diisopropylbenzene hydroperoxide metabolism or on diisopropylbenzene metabolism.
Bioaccumulation potential:
As the LogBCF is 2, diisopropylbenzene hydroperoxide is not anticipated to accumulate in the human body.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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