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EC number: 244-034-6 | CAS number: 20780-49-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Estimation 96 hrs LC50 value of test chemical on Fathead minnow by Danish QSAR database.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fathead minnow
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.33 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Table: Table showing the Fathead minnow 96 hr LC50 values estimated by two different models i.e, Leadscope and SciQSAR & the average LC50 value was given by the third model i.e, Battery model.
DK
Battery
Leadscope
SciQSAR
Fathead minnow96 hr
LC50 (mg/l)
2.33176
2.546504
2.117017
Domain
IN
IN
IN
Where,
IN = inside applicability domain- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on effect of test chemical on the mortality of the test organism Fathead minnow, the 96 hrs LC50 by three different model i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database was estimated to be 2.33 mg/l.
- Executive summary:
Estimated 96 hrs LC50 value of test chemical on the test organism Fathead minnow was evaluated by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database. On the basis of effect of test chemical on the mortality of the test organism Fathead minnow, the 96 hrs LC50 was estimated to be 2.33 mg/l.Thus, based on the LC50 value, chemical can be considered as toxic to aquatic organisms. Since the test chemical is readily biodegradable in water, test chemical can be considered as non-toxic to aq. organisms and thus can be considered to be not classified as per CLP classification criteria.
Reference
Description of key information
Estimated 96 hrs LC50 value of test chemical on the test organism Fathead minnow was evaluated by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database (2017). On the basis of effect of test chemical on the mortality of the test organism Fathead minnow, the 96 hrs LC50 was estimated to be 2.33 mg/l.Thus, based on the LC50 value, chemical can be considered as toxic to aquatic organisms. Since the test chemical is readily biodegradable in water, test chemical can be considered as non-toxic to aq. organisms and thus can be considered to be not classified as per CLP classification criteria.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.33 mg/L
Additional information
Predicted data of the test chemical and various supporting weight of evidence studies for its structurally similar read across chemical were reviewed for the short term toxicity to fish end point which are summarized as below:
In a prediction done usingthree different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database(2017), theEstimated 96 hrs LC50 value of test chemical on the test organism Fathead minnow was evaluated. On the basis of effect of test chemical on the mortality of the test organism Fathead minnow, the 96 hrs LC50 was estimated to be 2.33 mg/l.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2018),an acute toxicity test was conducted for 96 hrs for assessing the effect of test chemical on Oryzias latipes (Japanese rice fish). The test was performed in accordance to OECD guideline No. 203“Fish Acute Toxicity Test”. Oryzias latipes (Japanese rice fish) was used as a test organism for the study. Test chemical conc. used for the study were 35.0, 26.9, 20.7, 15.9, 12.3 mg/L (geometric ratio1.3), control. Analytical monitoring involve the use of HS-GC. Study was performed using 10 per conc. (5 per vessel) Oryzias latipes in a semi-static fresh water system. Total 50 fishes were exposed to test chemical in a closed vessel. The test vessels were placed under a photoperiod of room light, 16:8 hr light: dark conditions, respectively. On the basis of mortality of the test organism Oryzias latipes (Japanese rice fish), the 96 hrs LC50 value was determined to be 16.6 mg/l (95% C. I. – 12.3 to 23.8 mg/l), respectively.
For the test chemical, Short term toxicity to fish study was carried out for 96 hrs (Handbook, 2009). The study was based on the effects of the test chemical on Pimephales promelas in a static fresh water system. Pimephales promelas (Fathead minnow) was used as a test organism. On the basis of mortality of the test organism Pimephales promelas, the 96 hr LC50 was determined to be 18 mg/l.
On the basis of the above results, it can be concluded that the test chemical can be considered astoxic to fish. Since the test chemical is readily biodegradable in water, test chemical can be considered as non-toxic to fish and thus can be considered to be not classified as per CLP classification criteria.
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