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EC number: 233-864-4 | CAS number: 10401-55-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 75.3% after 28 d (O2 consumption, OECD 301B)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Since no studies investigating the ready biodegradability of Hexadecyl (R)-12-hydroxyoleate (CAS 10401-55-5) are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related analogue substance docosyl docosanoate (CAS 17671-27-1) was conducted. The read-across substance is representative to evaluate the biodegradation of the target substance hexadecyl (R)-12-hydroxyoleate. Hexadecyl (R)-12-hydroxyoleate is mainly specified as an ester of a linear C16 alcohol and a C18:1(OH) fatty acid. Docosyl docosanoate is characterized by a longer fatty acid chain length (C22) and a longer fatty alcohol chain length (C22) and can be used for read-across as a worst case approach since the chain length of the fatty alcohol and the fatty acid are the determining factor for biodegradation. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The study with the source substance docosyl docosanoate was performed according to OECD 301C (GLP) under aerobic conditions using a mixture of activated sludge from STP with freshwater from rivers and lakes, marine water and marine sediment as inoculum with a test substance concentration of 100 mg/L (Ministry of Economy, Trade and Industry, Japan, 1992). A biodegradation of 75.3% (BOD) was observed after 28 d. Since the substance reached the pass level for OECD 301C (biodegradation is > 60% after 28 d, no 10-day window required) docosyl docosanoate is readily biodegradable according to the OECD criteria.
This result is supported further by reliable (Q)SAR calculations for the main components of the UVCB substance using VegaNIC v1.1.0. The substance fits in the applicability domain of the model and the prediction is “readily biodegradable”.
Based on the results from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) and reliable (Q)SAR estimations for the target substance itself it can be concluded that Hexadecyl (R)-12-hydroxyoleate is readily biodegradable according to the OECD criteria.
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