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Diss Factsheets
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EC number: 224-929-8 | CAS number: 4559-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- : no histopathologic examination
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no further data
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Amount applied: 3.1 - 5.66 mL
- Doses:
- 6250, 9000, 14624, 17206 or 19789 mg/kg bw
- No. of animals per sex per dose:
- 10 m
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
Necropsy of survivors performed: no
Other examinations performed: clinical signs and body weight - Statistics:
- Probit
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 16 742 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 14 422 - 20 325
- Mortality:
- 0/10, 0/10, 4/10, 5/10 and 7/10
- Clinical signs:
- other: >= 6250 mg/kg: salivation, wet and stained perianal area, congestion, stained mouth, nose and feet, chromodacryorrhea, alopecia, tremors, fasciculations, piloerection, and weight loss >= 9000 mg/kg: diarrhoea, weakness and ruffled fur >= 14624 mg/kg: eyes
- Gross pathology:
- no data
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- With an oral LD50 value of 16742 mg/kg bw in rats, 1,1,3,3-tetrabutyl-urea is practically nontoxic.
- Executive summary:
1,1,3,3-tetrabutyl-urea was tested in an acute oral toxicity study with rats. Five groups of 10 male ChR-CD rats were dosed once via gavage with 6250, 9000, 14624, 17206 or 19789 mg/kg bw. With an oral LD50 value of 16742 mg/kg bw, 1,1,3,3 -tetrabutyl-urea was practically nontoxic.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 16 742 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not available (only very brief summary)
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not further specified
- GLP compliance:
- no
- Test type:
- other: not further specified
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 7 500 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- For the test substance a LD50 value of > 7500 mg/kg bw was given.
- Executive summary:
For male rabbits a dermal LD50 value of > 7500 mg/kg bw has been reported.
Reference
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 7 500 mg/kg bw
Additional information
1,1,3,3-tetrabutyl-urea was tested in an acute oral toxicity study with rats. Five groups of 10 male ChR-CD rats were dosed once via gavage with 6250, 9000, 14624, 17206 or 19789 mg/kg bw. With an oral LD50 value of 16742 mg/kg bw, 1,1,3,3-tetrabutyl-urea was practically nontoxic.
For male rabbits a dermal LD50 value of > 7500 mg/kg bw has been reported.
Justification for classification or non-classification
From the available data it can be concluded that the acute toxicity of 1,1,3,3-tetrabutylurea is low. Therefore, there is no need for classification and labelling.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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