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Diss Factsheets
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EC number: 223-981-9 | CAS number: 4151-51-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Tris(p-isocyanatophenyl) thiophosphate is slightly irritating to the pulmonary tissue of rats after single nose-only inhalation exposure for 6 hours. The trade product with about 27% tris(p-isocyanatophenyl) thiophosphate in ethyl acetate is slightly irritating to the skin of rabbits and not irritating to the eye of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: LPT Laboratory of Pharmacology and Toxicology KG, 24601 Löhndorf/Post Wankendorf, Germany
- Age at study initiation: appr. 4.5 months
- sex: males - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: surrounding untreated skin area of test animals served as control
- Amount / concentration applied:
- Amount: 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48, 72 hours, and 4 days after application; maximal observation time 24 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: approx. 6 cm²
- Type of wrap if used: non irritating tape
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize - Irritation parameter:
- erythema score
- Basis:
- animal: #1-#3
- Time point:
- other: 24 and 48 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks:
- day 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks:
- day 4
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 and #3
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal #1 - #3
- Time point:
- other: 24 to 72 hours
- Score:
- 0
- Max. score:
- 4
- Other effects:
- There were no systemic intolerance reactions.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
Classification: not irritating- Executive summary:
In a study performed according to OECD 404 the test item (27% tris(p-isocyanatophenyl) thiophosphate in ethyl acetate) was shown to be slightly irritating to the rabbit's skin. Erythema grade 1 was observed in all 3 animals 24 and 48 hours after treatment. These effects disappeared on day 3 to 4 after treatment. No systemic intolerance reactions were observed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Sex: female
- Source: LPT Laboratory of Pharmacology and Toxicology KG, Löhndorf, Germany
- Age at study initiation: appr. 3.5 months
- sex: males - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: one untreated eye of test animals served as control
- Amount / concentration applied:
- Amount: 0.1 ml
- Duration of treatment / exposure:
- single treatment; the lid was held together for about one second after instillation
- Observation period (in vivo):
- the eyes were examined ophthalmoscopically with a slit lamp prior to the administration and also 1, 24, 48, 72 hours post application. 24 hours after administration the eyes were treated additionally with fluorescein and examined.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: none
SCORING SYSTEM: Draize - Irritation parameter:
- overall irritation score
- Remarks:
- cornea, iris, and conjunctivae
- Basis:
- mean
- Time point:
- other: 24 h, 48 h, 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 1 hour after instillation redness of conjunctivae (grade 1; all animals), chemosis (grade 1; 1 animal) , and cornea opacity (grade 1; 2 animals) was observed
- Other effects:
- There were no systemic intolerance reactions.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
Classification: not irritating- Executive summary:
In a study performed according to OECD 405 the test item (27% tris(p-isocyanatophenyl)thiophosphate in ethyl acetate)
did not induce irritant effects in the eye of rabbits. There were no systemic intolerance reactions.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Tris(p-isocyanatophenyl) thiophosphate is marketed and handled as solution in ethyl acetate containing approximately 27% of tris(p-isocyanatophenyl) thiophosphate. Removal of the solvent from a solution of 27% of tris(p-isocyanatophenyl) thiophosphate in ethyl acetate does invariably lead to generation of higher molecular weight species. This is due to the inherent reactivity of the isocyanate moieties and the process can thus be monitored via the decrease of the isocyanate content (see IUCLID section 1.4: analytical material balances before/after solvent removal). Therefore, a solution of 27% of tris(p-isocyanatophenyl) thiophosphate in ethyl acetate was employed as test substance for all toxicological tests as this was believed to best represent the substance to be registered.
Skin irritation/corrosion
In a study performed according to OECD 404 the test
item (27% tris(p-isocyanatophenyl) thiophosphate in ethyl acetate) was
shown to be slightly irritating to the rabbit's skin. Erythema grade 1
was observed in all 3 animals 24 and 48 hours after treatment. These
effects disappeared on days 3 to 4 after treatment. No systemic
intolerance reactions were observed.
Eye irritation/severe eye damage
In a study performed according to OECD 405 the test
item (27% tris(p-isocyanatophenyl) thiophosphate in ethyl acetate) did
not induce irritant effects in the eye of rabbits. There were no
systemic intolerance reactions.
Respiratory tract irritation
In an inhalation toxicity study performed on rats according to OECD 403 and TRGS 430 (see IUCLID section 7.2.2) the aerosolized test item (active ingredient) was shown to be a slight pulmonary irritant. The exposure level considered to be the NOAEL for pulmonary irritation was determined with 5.6 mg/m³.
Justification for selection of skin irritation / corrosion endpoint:
Only one study available.
Justification for selection of eye irritation endpoint:
Only one study available.
Justification for classification or non-classification
No
classification is required with regard to skin, eye and respiratory
tract irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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