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Diss Factsheets

Administrative data

Description of key information

No internal acute toxicity studies of aldonaethylenolether are available. 
Results of an acute oral toxicity study are cited in RTECS database (Juli 2011):
Oral (rat): LD (lethal dose) > 3000 mg/kg
(Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third. Ave., New York, NY 10128) V.1- 1990- v. 1, p. 156, 1992 (ATDAEI))

Key value for chemical safety assessment

Additional information

Results of an acute toxicity study with aldonaethylenolether are cited in RTECS database (Juli 2011):

Oral application of aldonaethylenolether to rats results in LD > 3000 mg/kg [Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third. Ave., New York, NY 10128) V.1- 1990- v. 1, p. 156, 1992 (ATDAEI)]

Additionally, GLP-guideline studies with aldona, the pharmacological active metabolite of aldonaethylenolether, were conducted.

The single oral administration of aldona to male and female Wistar rats (3/sex) at the dose of 2000 mg/kg resulted in transient rough hair coat, apathy, squatting position, decreased body temperature only in females shortly after administration. No mortalities occurred and no compound-related macroscopic findings were seen. The LD50 was determined to be above 2000 mg/kg [Schering AG, Report No. A03235; 2001-02-26; OECD TG 423]

The single dermal application of aldona to rats (3/sex) for 24 hours (occlusively) did not induce any clinical or pathological signs. Again, the LD50 was determined to be above 2000 mg/kg [Schering AG, Report No. A03234; 2001-02-26; OECD TG 402].

Justification for classification or non-classification

Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP) is not required.