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Diss Factsheets
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EC number: 218-817-8 | CAS number: 2243-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In order to establish the maximum tolerated concentrations of the test substance for administration to dosed animals in a chronic study, a subchronic toxicity study was conducted with Fischer-344 -rats of both sexes.
The concentrations used were: 0.03; 0.1; 0.3; 1.0 and 3.0 %(ca. 20, 67, 200, 667 or 2000 mg/kg/d) . The dosed dietary preparations were administered for 8 weeks.
Deaths were recorded for all groups of rats receiving concentrations of 0.3 % or more (no Nr. of animals given).
Mean body weight depression was approximately 19 and 9 %, respectively, in males and females dosed with 0.1 % of test substance. No effect level based on this study. Only bw. And mortality examined.
The dose chosen as highest concentration of test substance in the rat chronic bioassay was 0.1 %.
Additionally a subchronic toxicity study was conducted with B6C3F1 mice of both sexes.
The concentrations used were: 0,03; 0,1; 0,3; 1,0 and 3,0 %(ca. 43, 143, 429, 1429 or 4286 mg/kg/d) . The dosed dietary preparations were administered for 8 weeks.
Deaths were recorded for all groups of mice receiving concentrations of 0,3 % or more (no Nr. of animals given).
Mean body weight depression was approximately 22 and 3 %, respectively, in males and females dosed with 0,3 % of test substance.
Males receiving 0,1 % experienced mean body weight depression of approximately 3 %.
The highest concentration of test substance in the mouse chronic bioassay was 0,2 % (NCI 1978).
25 female Wistar-rats received 1,5 -naphthylenediamine by gavage (dose: 0; 2; 10; 50 mg/kg bw.) daily from day 6 to day 15 of gestation.
From 10 mg/kg bw./day the food consumption and weight gain were influenced.
In the 50 mg/kg dose group sporadic heightened urine excretion was observed and additionally in one animal an increased water consumption detected.
No meaningfull pathological-anatomical findings and no mortalities were observed.
From 10 mg/kg bw/day a marginal diminuated weight of fetuses was identified.
The NOAEL f...
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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