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EC number: 213-909-4 | CAS number: 1066-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
NOAEL (90-d oral, rat) >= 2015 mg/kg bw/day
NOAEL (90-d oral, mouse) >= 4342 mg/kg bw/day
LOAEC, local (90-d, inhalation, rat) = 21 mg/m³
NOAEC, systemic (90-d, inhalation, rat) = 210 mg/m³
NOAEL, dermal, systemic (extrapolation from 90-d oral rat) >= 2015 mg/kg bw/day
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEC
- 21 mg/m³
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 2), and is thus sufficient to fulfil the standard information requirements set out in Annex VIII-IX, 8.6, of Regulation (EC) No 1907/2006.
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Subchronic oral administration of the source substance Cr(III) picolinate to mice and rats (10 animals/sex/dose) in a study performed similar to OECD 408 showed no substance-related effects regarding body weight, food consumption, haematology, clinical chemistry, gross pathology, organ weight determinations and histopathology (Rhodes et al., 2005). No death occured. The only clinical sign observed was reddening of the faeces of the high dose animals which was due the the reddish colour of the test susbtance. The NOAELs in rats and mice were ≥ 2015 and ≥ 4342 mg/kg bw/day, respectively, when corrected for the molecular weight of basic Cr(III) acetate monohydrate. The lack of systemic effects even at very high dietary levels are reflective of the poor oral bioavailability of Cr(III).
Subchronic inhalation exposure of rats (10 animals/sex/dose) to the source substance soluble basic chromium sulphate dust at 17, 54, or 168 mg/m³ in a study performed similar to OECD 413 produced effects on the respiratory tract without indications for systemic effects (Derelanko et al. 1999). Basic chromium sulphate produced severe and widespread effects in the nasal cavity, larynx, lungs, and mediastinal lymph node. Effects were characterized by accumulation of foreign material, infiltration of alveolar macrophages, septal cell hyperplasia, and granulomatous and chronic inflammation. Pigment was still present in basic chromium sulphate-treated animals after the 13-week recovery period, with partial recovery of the pathological lesions. An NOAEC for effects on lung was not established; The LOAEC for basic chromium sulphate was 17 mg/m³. This is equivalent to 21 mg/m³ basic chromium(III) acetate monohydrate.
These effects can be considered as local effects on the respiratory tract. Substance-related systemic effects were not observed. The observed organ weights effects can be considered secondary to the stress imposed on the respiratory tract and the resulting impairment of body weight gain. Therefore, the systemic NOAEC is 210 mg/m³.
A subchronic dermal study is not deemed necessary, since the dermal absorption of Cr(III) salts can be predicted to be very low, judging from the very low (<1%) gastrointestinal absorption and the lack of acute percutaneous toxicity. Because of the skin-sensitizing properties of basic Cr acetate, skin contact must be avoided by wearing appropriate protective clothing. As a result, dermal exposure will be insignificant.
The oral NOAEL can be extrapolated to the dermal route, since dermal absorption is expected to be in the same order of magnitude as oral absorption (<1%).
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
The selected study is the most adequate and reliable study with the longest duration and the lowest dose descriptor.
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
There is only one study available.
Justification for selection of repeated dose toxicity inhalation - local effects endpoint:
There is only one study available.
Justification for classification or non-classification
The available data on repeated dose toxicity do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and is therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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