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Diss Factsheets
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EC number: 208-021-9 | CAS number: 505-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Remarks:
- ECOSAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well known model generally regarded as reliable. Cited as source of information in REACH guidance on information requirements and chemical safety assessment
- Justification for type of information:
- 1. SOFTWARE
ECOSAR
2. MODEL (incl. version number)
(v2.0)
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CCCOCOCCC
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
[[Explain how the model fulfils the OECD principles for (Q)SAR model validation. Consider attaching the QMRF and/or QPRF or providing a link]
- Defined endpoint:
- Unambiguous algorithm:
- Defined domain of applicability:
- Appropriate measures of goodness-of-fit and robustness and predictivity:
- Mechanistic interpretation:
5. APPLICABILITY DOMAIN
See attached justification files
6. ADEQUACY OF THE RESULT
The 96-h LC50 value for fish is predicted to be 175 mg/L. There is no consequence for classification due to this effect value, as algae remains the most sensitive species to Propylal (i.e. shows the lowest ErC50 > 15.8 mg/L, OECD TG 201, GLP). - Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR method based on chemical class principle: ECOSAR (v2.0) from EPISUITE (US EPA)
- GLP compliance:
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 175 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The increasing toxic effect with increasing length of the chain alkane (i.e. the toxicity level is Ethylal< Propylal < Butylal) is found for all three trophic levels (fish, invertebrates and algae) in experimental studies and ECOSAR predicted results. Therefore, Propylal is expected to be more toxic to fish than Ethylal. It means the effect value from the short-term toxicity to fish study on Ethylal cannot be used for read-across to Propylal, since Propylal is expected to be more toxic. No experimental study is available on Butylal, which is expected to be significantly more toxic than Propylal. Based on this information, ECOSAR is deemed more appropriate for this endpoint than the read-across approach. Therefore, the 96-h LC50 value of Propylal to fish is predicted to be 175 mg/L according to ECOSAR (v2.0). The QMRF and QPRF are attached to this endpoint of the dossier.
- Executive summary:
A short-term toxicity study to fish is available for Ethylal (source substance 1), but not for Butylal (source substance 2). ECOSAR results show an increasing toxic effect trend with increasing length of the chain alkane (from C5 to C9) for all three trophic levels (fish, invertebrates and algae). The trend is also found in the available experimental studies on aquatic invertebrates. The 48-h E(L)C50 values for daphnia were determined to be 468 (publication, not GLP), > 100 (OECD TG 202, GLP) and > 28.7 mg/L (OECD TG 202, GLP) for Ethylal, Propylal and Butylal, respectively. Experimental studies are available for the toxicity to algae and cyanobacteria endpoint for Propylal and Butylal, but not for Ethylal. Therefore, it is difficult to study the trend of toxicity levels of these three substances via the available studies. But Butylal (72h-ErC50 > 1.3 mg/L; 72h-NOErC < 1.3 mg/; OECD TG 201, GLP) shows higher toxicity than Propylal (72h-ErC50 > 15.8 mg/L; 72h-NOErC = 1.09 mg/; OECD TG 201, GLP), which is in line with the trend observed for the other trophic levels. ECOSAR was used for Ethylal, Propylal (target substance) and Butylal, and predicted the 96h-LC50 values for fish are 1050, 175 and 27.8 mg/L, respectively.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 175 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.