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Diss Factsheets
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EC number: 205-710-6 | CAS number: 148-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- <= -1.1
- Temp.:
- 20 °C
- pH:
- >= 7 - <= 9
- Details on results:
- The experimental determination of the partition coefficient of Sodium diethyldithiocarbamate could not be conducted according to OECD test guidelines 107 and 117 as they are not applicable to this test item. To fulfil the requirements of the OECD test guidelines, the partition coefficient of a test item should be determined using the test item in its undissociated (neutral) form. Furthermore, the test item has to be stable in water and octanol during the test period.
The test item Sodium diethyldithiocarbamate is a salt which dissociates in water.
The OECD test guideline 117 (HPLC Method) could not be performed because the test item Sodium diethyldithiocarbamate hydrolyses too rapidly into carbon disulfide and a-n- diethylamine and therefore the distribution behaviour of the parent substance could not be determined.
Nevertheless the determination of the partition coefficient was performed as preliminary test according to OECD test guidelines 107 (Shake Flask Method) using UV-VIS spectroscopy as detection method.
It was possible to distinguish between the test item and free carbon disulfide in the octanol phase by using UV-VIS detection.
Therefore, only the results of the preliminary tests are reported. This is obviously in line with the common expectation that ionisable substances remain preferably in the aqueous phase.
The partition coefficient of the test item was found to be: log Pow = < - 1.1
Additionally the partition coefficient was calculated for Sodium diethyldithiocarbamate applying the software KOWWIN v1.67 owned by the U.S. Environmental Protection Agency.
The partition coefficient of the test item was: log Pow = - 1.4 (calculated as non-dissociated sodium component) - Conclusions:
- The partition coefficient of the test isubstance was found to be log Pow = < - 1.1 at 20 °C, where the pH is expected to be between 7 and 9
- Executive summary:
The conventional determination of the octanol-water partition coefficient (Log Pow) could not be performed following OECD TG 117 (HPLC Method) as the test substance rapidly hydrolysis into carbon disulfide and a n-diethylamine. Since the distribution behaviour of the parent substance could not be determined, the test substance was assessed in its undissociated (neutral) form.
The octanol-water partition coefficient (Log Pow) was performed in a preliminary test according to OECD TG 107 (Shake Flask Method) using UV-VIS spectroscopy. This detection method allowed to distinguish between the test item and free carbon disulfide in the octanol phase. This is obviously in line with the common expectation that ionisable substances remain preferably in the aqueous phase. At 20 °C, the partition coefficient of the test substance was found to be log Pow = < - 1.1, where the pH is expected to be in a range 7 and 9.
Calculating the partition coefficient by applying the software KOWWIN v1.67 showed a partition coefficient of log Pow = - 1.4 (calculated as non-dissociated sodium component)
Reference
No data on pH are available; however, based on the experiments with structurally related substance sodium dibutyldithiocarbamate and considering the structure of the substance, pH is expected to be in a range 7-9.
Description of key information
log Kow=<-1.1 at 20 ˚C (experimental)
log Kow = -1.4 (calculated with KOWWIN v1.67 as undissociated sodiuem diethyldithiocarbamate)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.1
- at the temperature of:
- 20 °C
Additional information
Data from a GLP-compliant guideline study, adequate for assessment.
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