Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-983-6 | CAS number: 112-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance was assessed for acute oral toxicity in rats. Under the conditions of the test, the test substance had an LD50 of 23100 mg/kg bw.
The test substance was assessed for acute dermal toxicity in rabbits. The test substance had an LD50 > 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats fed three dose levels of test material and observed for 14 d for mortality
- GLP compliance:
- no
- Remarks:
- study predates GLP
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 150 g to 208 g
- Fasting period before study: 16 hrs
- Housing: Stock cages prior to dosing, individually in wire-mesh cages after dosing.
- Diet: Standard laboratory diet, ad libitum
- Water: Ad libitum
- Acclimation period: 5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 10.2 g/kg bw, 15.4 g/kg bw, 23.1 g/kg bw
- No. of animals per sex per dose:
- 2 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: Initial and final body weights recorded
- Animals sacrificed after 14 d.
- Necropsy of all animals performed. - Statistics:
- LD50s were calculated using the techniques of Weil, Thompson, and Thompson and Weil.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 23 100 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Both females in the highest group died, 12-F at 12 d, 11-F at 13 d.
- Clinical signs:
- other: 10.2 g/kg bw dose: Hypoactivity beginning 30 min following dose administration and which lasted 2 days, ruffed fur beginning 1 h following dose administration and which lasted 1 day. 15.4 g/kg bw dose: Hypoactivity beginning 30 min following dose admini
- Gross pathology:
- - Necropsy of animals that died revealed haemorrhages of the stomach.
- Haemorrhages were also observed in animal 10-M (23.1 g/kg bw dose level).
- No other gross pathological alterations were noted. - Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- The test substance was assessed for acute oral toxicity in rats. Under the conditions of the test, the test substance had an LD50 of 23100 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 23 100 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test material applied to skin of 4 rabbits for 24 hrs at a dose of 2000 mg/kg bw; rabbits then observed for 14 d, necropsied.
- GLP compliance:
- no
- Remarks:
- Study predates GLP
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 2.50-3.10 kg
- Fasting period before study: No
- Housing: Individually in hanging rabbit cages
- Diet: Standard laboratory rabbit ration, ad libitum
- Water: Ad libitum
- Acclimation period: ≥ 7 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Back
- Type of wrap if used: Plastic
REMOVAL OF TEST SUBSTANCE
- Washing.
- Time after start of exposure: 24 hrs - Duration of exposure:
- 24 hrs
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2 male, 2 female per the single dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Necropsy of survivors performed.
- Other examinations performed: Clinical signs. - Statistics:
- LD₅₀ was calculated.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/4
- Clinical signs:
- other: No behavioural reactions were exhibited by any of the animals.
- Gross pathology:
- No gross pathological alterations were noted.
- Other findings:
- - Other observations: Skin reaction; definite red erythema and mild oedema of the skin were noted after 24 hrs of contact. After 6 d, superficial escharosis was evident. By the end of the 14 d observation period, the skin had begun to slough.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance was assessed for acute dermal toxicity in rabbits. The test substance had an LD50 > 2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity
The test substance was assessed for acute oral toxicity in rats. In the high dosage group both females died at 12 and 13 days following administration of the test substance; necropsy revealed haemorrhages of the stomach. Haemorrhages of the stomach were also observed in one male in the 23.1 g/kg bw dose level. No other gross pathological alterations were noted. Clinical signs noted were hypoactivity, ruffed fur, muscular weakness and emaciation. Under the conditions of the test, the test substance had an LD50 of 23100 mg/kg bw.
Acute inhalation
No study available.
Acute dermal toxicity
The test substance was assessed for acute dermal toxicity in rabbits. There was no mortality during the test and no behavioural reactions were exhibited by any of the animals. No gross pathological alterations were noted. Signs of dermal irritation were noted, however including definite red erythema and mild oedema of the skin after 24 hrs of contact. After 6 d, superficial escharosis was evident. By the end of the 14 d observation period, the skin had begun to slough. The test substance had an LD50 > 2000 mg/kg bw.
Justification for classification or non-classification
Based on the acute oral LD50 values of 23100 mg/kg bodyweight and the acute dermal value of 2000 mg/kg bodyweight the test substance does not need to be classified according to the criteria outlined in Annex VI of 67/548/EEC (DSD) and Annex I of 1272/2008/EC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.