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EC number: 201-781-2 | CAS number: 87-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 8 weeks
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Dietary Inositol Requirement for Juvenile Grass Shrimp, Penaeus monodon
- Author:
- Shiau S-Y and Su S-L
- Year:
- 2 004
- Bibliographic source:
- Aquaculture, 241:1-8
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Myo-inositol
- EC Number:
- 201-781-2
- EC Name:
- Myo-inositol
- Cas Number:
- 87-89-8
- Molecular formula:
- C6H12O6
- IUPAC Name:
- cyclohexane-1,2,3,4,5,6-hexol
- Test material form:
- solid
- Details on test material:
- - Purity: not reported
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- other: Grass shrimp, Penaeus monodon
Study design
- Test type:
- other: Feeding study
- Limit test:
- no
- Total exposure duration:
- 8 wk
- Post exposure observation period:
- None
Test conditions
- Hardness:
- not reported
- Test temperature:
- 26 to 29°C
- pH:
- 6.6 to 6.8
- Dissolved oxygen:
- Averaged at 7.3 mg O2/L
- Salinity:
- 19 to 21 g/kg
- Conductivity:
- not reported
- Nominal and measured concentrations:
- Nominal: 250, 500, 1000, 2000, 4000. 6000, and 8000 mg/kg of diet
Analytical: 295, 696, 1079, 2036, 3943, 6159, and 8218 mg/kg of diet - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 8 wk
- Dose descriptor:
- LC50
- Effect conc.:
- >= 8 000 other: mg/kg diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: The survival data indicated that there was a gradual attrition during the 8-week duration of the experiment.
- Details on results:
- Weight gain, protein efficiency ratio and survival were highest for shrimp fed diets supplemented with ≥ 3943 mg/kg, followed by 2036 mg/kg and lowest for shrimp fed diets supplemented with ≤ 696 mg/kg. The values for these three dietary treatments were significantly different from one another (P<0.05). The survival data indicated that there was a gradual attrition during the 8-week duration of the experiment.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Shrimp fed diets supplemented with ≥3943 mg/kg (≥4000 mg/kg nominal) of diet had significantly (P<0.05) survival.
- Executive summary:
The dietary test substance requirement of juvenile grass shrimp, Penaeus monodon, was estimated. Purified basal diets were formulated using vitamin-free casein as the protein source. Dietary treatments consisted of graded levels (0, 250, 500, 1000, 2000, 4000, 6000 and 8000 mg/kg of diet) of the test substance added to a basal diet. Each diet was fed to three replicate groups of shrimp initially averaging 0.44±0.01 g for 8 weeks. Shrimp fed diets supplemented with ≥3943 mg/kg of diet had significantly (P<0.05) greater weight gain, protein efficiency ratio (PER), survival and levels of the test substance in the midgut gland than those fed diets supplemented with ≤2036 mg/kg of diet. Lipid in the midgut gland of shrimp fed diets supplemented with ≥1079 mg/kg of diet was higher than that of shrimp fed diets supplemented with ≤696 mg/kg of diet. The midgut gland index (MGI) of shrimp fed diets supplemented with ≥3943 mg/kg of diet was lower than that of shrimp fed diets containing ≤1079 mg/kg of diet. Weight gain percentage, the level of test substance in the midgut gland and the midgut gland index values for the different treatments were analyzed by broken-line regression and indicated that the requirement for dietary test substance in growing P. monodonis was approximately 3400 mg/kg of diet.
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