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Diss Factsheets
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EC number: 200-580-7 | CAS number: 64-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study report has not been received and therefore cannot be reviewed and evaluated in full.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 202-II
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Acetic acid
- EC Number:
- 200-580-7
- EC Name:
- Acetic acid
- Cas Number:
- 64-19-7
- Molecular formula:
- C2H4O2
- IUPAC Name:
- acetic acid
- Details on test material:
- Acetic acid technical 60%. Lot/batch A07ET265, Purity not stated.
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No further details
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Counting of new-born living daphnia and living adults. Average oxygen content, aaerage pH, substnace concentration and temperature were checked at the beginning 3 time weekly after test initiation and 21 days after test initiation. Effects of test substnace observed daily.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test solutionsrenewed 8 times in the exposure period.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- 2-24h old
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Post exposure observation period:
- Not applicable
Test conditions
- Hardness:
- Not reported
- Test temperature:
- 20°C±1
- pH:
- 7.52-7.98
- Dissolved oxygen:
- 7.8-8.6mg/l
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0, 84, 88, 93, 97, 102, 107 mg/l. Measured concentrations (time-weighted mean): 0, 52.4, 47.9, 54.3, 65.5, 73.8, 59.7mg/l.
- Details on test conditions:
- Daphnia fed green algae ( Scenedesmus subspicatus).
Concentrations tested with 8 replicates.
40 animals divided into groups of 10 animals in each test concentration and control - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 80 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: 60% acetic acid
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 31.4 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: For 100% acetic acid
- Details on results:
- Recovery rates of acetic acid in the test medium were below 80% of nominal before water renewal. EC50 values calculated with nominal and with measured (TWM) concentrations.
- Results with reference substance (positive control):
- not reported
- Reported statistics and error estimates:
- Determination of EC50 was carried out by probit analysis.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEC for reproduction, based on mean measured concentrations, was reported to be 80mg/l for 60% acetic acid. The NOEC for reproduction, based on mean measured concentrations, was determined to be to be 31.4mg/l for 100% acetic acid.
- Executive summary:
The NOEC for reproduction, based on mean measured concentrations, was determined to be to be 31.4mg/l for 100% acetic acid. This study is GLP compliant and follows a standard guideline. It is considered suitable for use as a key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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