Candidate List of substances of very high concern for Authorisation

(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

Notes:

Authentic version: Only the Candidate List published on this website is deemed authentic. Companies may have immediate legal obligations following the inclusion of a substance in the Candidate List on this website including in particular Articles 7, 31 and 33 of the REACH Regulation.
Numerical identifiers: Each candidate list entry covers both anhydrous and hydrated forms of a substance. The CAS number shown in an entry is typically for the anhydrous form. Hydrated forms of the substance identified by other CAS numbers are still within the scope of the entry.
Other numerical identifiers: For those entries with "-" in the EC number and CAS number columns, a non-exhaustive inventory of EC and/or CAS Registry numbers describing substances or groups of substances considered to fall within the scope of the Candidate List entry is included, where practicably possible. This information can be accessed through the "Details" button of the selected entry.

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Showing 1 - 200 of 233 results.

Substance name	EC No.	CAS No.	Date of inclusion	Reason for inclusion	Decision
α,α-Bis[4-(dimethylamino)phenyl]-4 (phenylamino)naphthalene-1-methanol (C.I. Solvent Blue 4) with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)	229-851-8	6786-83-0	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
Zirconia Aluminosilicate Refractory Ceramic Fibres are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium, silicon and zirconium are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm). c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight show/hide Refractories, fibers, aluminosilicate EC No.: - \| CAS No.: 142844-00-6	-	-	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011 ED/95/2012	Details
Trixylyl phosphate	246-677-8	25155-23-1	16-Dec-2013	Toxic for reproduction (Article 57c)	ED/121/2013	Details
Tris(4-nonylphenyl, branched and linear) phosphite (TNPP) with ≥ 0.1% w/w of 4-nonylphenol, branched and linear (4-NP) show/hide Phenol, 4-nonyl-, phosphite (3:1) EC No.: - \| CAS No.: 3050-88-2 tris(nonylphenyl) phosphite EC No.: 247-759-6 \| CAS No.: 26523-78-4 tris(4-nonylphenyl, branched) phosphite EC No.: - \| CAS No.: - Phenol, p-isononyl-, phosphite (3:1) EC No.: - \| CAS No.: 31631-13-7 Phenol, p-sec-nonyl-, phosphite EC No.: - \| CAS No.: 106599-06-8	-	-	16-Jul-2019	Endocrine disrupting properties (Article 57(f) - environment)	ED/71/2019	Details
tris(2-methoxyethoxy)vinylsilane	213-934-0	1067-53-4	17-Jan-2022	Toxic for reproduction (Article 57c)	D(2021)10043-DC	Details
Tris(2-chloroethyl) phosphate	204-118-5	115-96-8	13-Jan-2010	Toxic for reproduction (Article 57c)	ED/68/2009	Details
Trilead dioxide phosphonate	235-252-2	12141-20-7	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Trilead diarsenate	222-979-5	3687-31-8	19-Dec-2011	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/77/2011	Details
Trilead bis(carbonate) dihydroxide	215-290-6	1319-46-6	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Triethyl arsenate -	427-700-2	15606-95-8	28-Oct-2008	Carcinogenic (Article 57a)	ED/67/2008	Details
Tricosafluorododecanoic acid	206-203-2	307-55-1	19-Dec-2012	vPvB (Article 57e)	ED/169/2012	Details
Trichloroethylene	201-167-4	79-01-6	18-Jun-2010	Carcinogenic (Article 57a)	ED/30/2010	Details
Tetralead trioxide sulphate	235-380-9	12202-17-4	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Tetraethyllead	201-075-4	78-00-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Tetraboron disodium heptaoxide, hydrate	235-541-3	12267-73-1	18-Jun-2010	Toxic for reproduction (Article 57c)	ED/30/2010	Details
Terphenyl, hydrogenated	262-967-7	61788-32-7	27-Jun-2018	vPvB (Article 57e)	ED/61/2018	Details
Sulfurous acid, lead salt, dibasic	263-467-1	62229-08-7	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Strontium chromate	232-142-6	7789-06-2	20-Jun-2011	Carcinogenic (Article 57a)	ED/31/2011	Details
Sodium peroxometaborate	231-556-4	7632-04-4	16-Jun-2014	Toxic for reproduction (Article 57c)	ED/49/2014	Details
Sodium perborate, perboric acid, sodium salt show/hide Perboric acid, sodium salt, tetrahydrate () EC No.: - \| CAS No.: 37244-98-7 Perboric acid (HBO(O2)), sodium salt, tetrahydrate EC No.: - \| CAS No.: 10486-00-7 Sodium perborate monohydrate EC No.: - \| CAS No.: 10332-33-9 Borate(2-), tetrahydroxybis[μ-(peroxy-κO1:κO2)]di-, sodium, hydrate (1:2:6) EC No.: - \| CAS No.: 125022-34-6 Borate(2-), tetrahydroxybis[μ-(peroxy-κO1:κO2)]di-, sodium (1:2) EC No.: - \| CAS No.: 90568-23-3 Perboric acid, sodium salt EC No.: 234-390-0 \| CAS No.: 11138-47-9 Perboric acid (H3BO2(O2)), monosodium salt, trihydrate EC No.: - \| CAS No.: 13517-20-9 Sodium perborate EC No.: 239-172-9 \| CAS No.: 15120-21-5	-	-	16-Jun-2014	Toxic for reproduction (Article 57c)	ED/49/2014	Details
Sodium dichromate	234-190-3	10588-01-9, 7789-12-0	28-Oct-2008	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c)	ED/67/2008	Details
Sodium chromate	231-889-5	7775-11-3	18-Jun-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c)	ED/30/2010	Details
Silicic acid, lead salt	234-363-3	11120-22-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Silicic acid (H2Si2O5), barium salt (1:1), lead-doped with lead (Pb) content above the applicable generic concentration limit for ’toxicity for reproduction’ Repr. 1A (CLP) or category 1 (DSD),the substance is a member of the group entry of lead compounds, with index number 082-001-00-6 in Regulation (EC) No 1272/2008	272-271-5	68784-75-8	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
S-(tricyclo(5.2.1.0'2,6)deca-3-en-8(or 9)-yl O-(isopropyl or isobutyl or 2-ethylhexyl) O-(isopropyl or isobutyl or 2-ethylhexyl) phosphorodithioate X4261	401-850-9	255881-94-8	17-Jan-2022	PBT (Article 57d)	D(2021)10043-DC	Details
Reaction products of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and 4-heptylphenol, branched and linear (RP-HP) with ≥0.1% w/w 4-heptylphenol, branched and linear (4-HPbl) show/hide Reaction product of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and phenol, heptyl derivs. EC No.: - \| CAS No.: 1471311-26-8 Formaldehyde, reaction products with branched and linear heptylphenol, carbon disulfide and hydrazine EC No.: 300-298-5 \| CAS No.: 93925-00-9	-	-	15-Jan-2018	Endocrine disrupting properties (Article 57(f) - environment)	ED/01/2018	Details
Reaction mass of 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate and 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (reaction mass of DOTE and MOTE)	-	-	17-Dec-2014	Toxic for reproduction (Article 57c)	ED/108/2014	Details
reaction mass of 2,2,3,3,5,5,6,6-octafluoro-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)morpholine and 2,2,3,3,5,5,6,6-octafluoro-4-(heptafluoropropyl)morpholine	473-390-7	-	17-Jan-2023	vPvB (Article 57e)	D(2022)9120-DC	Details
Pyrochlore, antimony lead yellow -	232-382-1	8012-00-8	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Pyrene	204-927-3	129-00-0	15-Jan-2019	PBT (Article 57d) vPvB (Article 57e)	ED/88/2018	Details
Potassium hydroxyoctaoxodizincatedichromate	234-329-8	11103-86-9	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Potassium dichromate	231-906-6	7778-50-9	18-Jun-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c)	ED/30/2010	Details
Potassium chromate	232-140-5	7789-00-6	18-Jun-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/30/2010	Details
Pitch, coal tar, high-temp. -	266-028-2	65996-93-2	13-Jan-2010	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Phenolphthalein	201-004-7	77-09-8	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Phenol, alkylation products (mainly in para position) with C12-rich branched alkyl chains from oligomerisation, covering any individual isomers and/ or combinations thereof (PDDP) show/hide Phenol, dodecyl-, branched EC No.: 310-154-3 \| CAS No.: 121158-58-5 Phenol, (tetrapropenyl) derivatives EC No.: - \| CAS No.: 74499-35-7 Phenol, tetrapropylene- EC No.: - \| CAS No.: 57427-55-1 Phenol, 4-dodecyl, branched EC No.: - \| CAS No.: 210555-94-5 4-isododecylphenol EC No.: - \| CAS No.: 27459-10-5 Phenol, 4-isododecyl- EC No.: - \| CAS No.: 27147-75-7	-	-	08-Jul-2021	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	D(2021)4569-DC	Details
Phenanthrene	201-581-5	85-01-8	15-Jan-2019	vPvB (Article 57e)	ED/88/2018	Details
Perfluorononan-1-oic-acid and its sodium and ammonium salts show/hide Perfluorononan-1-oic-acid EC No.: 206-801-3 \| CAS No.: 375-95-1 Sodium salts of perfluorononan-1-oic-acid EC No.: - \| CAS No.: 21049-39-8 Ammonium salts of perfluorononan-1-oic-acid EC No.: - \| CAS No.: 4149-60-4	-	-	17-Dec-2015	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/79/2015	Details
Perfluorohexane-1-sulphonic acid and its salts PFHxS show/hide perfluorohexane-1-sulphonic acid EC No.: 206-587-1 \| CAS No.: 355-46-4 ammonium perfluorohexane-1-sulphonate EC No.: 269-511-6 \| CAS No.: 68259-08-5 tridecafluorohexanesulphonic acid, compound with 2,2'-iminodiethanol (1:1) EC No.: 274-462-9 \| CAS No.: 70225-16-0 potassium perfluorohexane-1-sulphonate EC No.: 223-393-2 \| CAS No.: 3871-99-6 Ethanaminium, N-[4-[[4-(diethylamino)phenyl][4-(ethylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 1310480-24-0 Methanaminium, N-[4-[[4-(dimethylamino)phenyl][4-(ethylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 1310480-27-3 Methanaminium, N-[4-[[4-(dimethylamino)phenyl][4-(phenylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 1310480-28-4 Beta-Cyclodextrin, compd. with 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonic acid ion(1-)(1:1) EC No.: - \| CAS No.: 1329995-45-0 Gamma-Cyclodextrin, compd. with 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonic acid ion(1-)(1:1) EC No.: - \| CAS No.: 1329995-69-8 Sulfonium, triphenyl-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 144116-10-9 Quinolinium, 1-(carboxymethyl)-4-[2-[4-[4-(2,2-diphenylethenyl)phenyl]-1,2,3,3a,4,8b-hexahydrocyclopent[b]indol-7-yl]ethenyl]-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 1462414-59-0 Iodonium, diphenyl-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 153443-35-7 Methanaminium, N,N,N-trimethyl-, salt with 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonic acid (1:1) EC No.: - \| CAS No.: 189274-31-5 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, compd.with 2-methyl-2-propanamine (1:1) EC No.: - \| CAS No.: 202189-84-2 Iodonium, bis[4-(1,1-dimethylethyl)phenyl]-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 213740-81-9 Sulfonium, bis(4-methylphenyl)phenyl-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 341548-85-4 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, scandium(3+) salt (3:1) EC No.: - \| CAS No.: 350836-93-0 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, neodymium(3+) salt (3:1) EC No.: - \| CAS No.: 41184-65-0 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, yttrium(3+) salt (3:1) EC No.: - \| CAS No.: 41242-12-0 Sulfonium, (thiodi-4,1-phenylene)bis[diphenyl-, salt with 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonic acid (1:2) EC No.: - \| CAS No.: 421555-73-9 Iodonium, bis[4-(1,1-dimethylpropyl)phenyl]-, salt with 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonic EC No.: - \| CAS No.: 421555-74-0 Sulfonium, tris[4-(1,1-dimethylethyl)phenyl]-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 425670-70-8 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, lithium salt (1:1) EC No.: - \| CAS No.: 55120-77-9 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, zinc salt EC No.: - \| CAS No.: 70136-72-0 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, compd. with N,N-diethylethanamine (1:1) EC No.: - \| CAS No.: 72033-41-1 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, sodium salt EC No.: - \| CAS No.: 82382-12-5 Iodonium, bis[(1,1-dimethylethyl)phenyl]-, salt with 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonic acid (1:1) (9CI) EC No.: - \| CAS No.: 866621-50-3 Sulfonium, (4-methylphenyl)diphenyl-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 910606-39-2 Sulfonium, [4-[(2-methyl-1-oxo-2-propen-1-yl)oxy]phenyl]diphenyl-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 911027-68-4 Sulfonium, [4-[(2-methyl-1-oxo-2-propenyl)oxy]phenyl]diphenyl-, salt with 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonic acid (1:1), polymer with 2-ethyltricyclo[3.3.1.13,7]dec-2-yl 2-methyl-2-propenoate, 3-hydroxytricyclo[3.3.1.13,7]dec-1-yl 2-methyl-2-propenoate and tetrahydro-2-oxo-3-furanyl 2-methyl-2-propenoate EC No.: - \| CAS No.: 911027-69-5 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, cesium salt (1:1) EC No.: - \| CAS No.: 92011-17-1 Dibenzo[k,n][1,4,7,10,13]tetraoxathiacyclopentadecinium, 19-[4-(1,1-dimethylethyl)phenyl]-6,7,9,10,12,13-hexahydro-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 928049-42-7 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, compd. With pyrrolidine (1:1) EC No.: - \| CAS No.: 1187817-57-7 N,N,N-triethylethanaminium tridecafluorohexane-1-sulfonate EC No.: - \| CAS No.: 108427-55-0 N,N,N-tributylbutan-1-aminium tridecafluorohexane-1-sulfonate EC No.: - \| CAS No.: 108427-54-9 Phosphonium, triphenyl(phenylmethyl)-, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-1-hexanesulfonate (1:1) EC No.: - \| CAS No.: 1000597-52-3 1-Hexanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-, gallium salt (9CI) EC No.: - \| CAS No.: 341035-71-0	-	-	07-Jul-2017	vPvB (Article 57e)	ED/30/2017	Details
Perfluoroheptanoic acid and its salts show/hide Sodium perfluoroheptanoate EC No.: 243-518-4 \| CAS No.: 20109-59-5 potassium perfluoroheptanoate EC No.: - \| CAS No.: 21049-36-5 Ammonium perfluoroheptanoate EC No.: 228-098-2 \| CAS No.: 6130-43-4 Perfluoroheptanoic acid EC No.: 206-798-9 \| CAS No.: 375-85-9	-	-	17-Jan-2023	Toxic for reproduction (Article 57c) PBT (Article 57d) vPvB (Article 57e) Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2022)9120-DC	Details
Perfluorobutane sulfonic acid (PFBS) and its salts show/hide Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate EC No.: 249-616-3 \| CAS No.: 29420-49-3 Ammonium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate EC No.: 269-513-7 \| CAS No.: 68259-10-9 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonic acid EC No.: 206-793-1 \| CAS No.: 375-73-5 magnesium perfluorobutanesulfonate EC No.: - \| CAS No.: 507453-86-3 lithium perfluorobutanesulfonate EC No.: - \| CAS No.: 131651-65-5 N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate EC No.: - \| CAS No.: 25628-08-4 bis(4-t-butylphenyl)iodonium perfluorobutanesulfonate EC No.: 432-660-4 \| CAS No.: 194999-85-4 tetrabutyl-phosphonium nonafluoro-butane-1-sulfonate EC No.: 444-440-5 \| CAS No.: 220689-12-3 dimethyl(phenyl)sulfanium perfluorobutanesulfonate EC No.: 452-310-4 \| CAS No.: 220133-51-7 1-(4-butoxy-1-naphthalenyl)tetrahydrothiophenium 1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonate EC No.: 468-770-4 \| CAS No.: - Triphenylsulfanium perfluorobutane sulfonate EC No.: 478-340-8 \| CAS No.: 144317-44-2 morpholinium perfluorobutanesulfonate EC No.: - \| CAS No.: 503155-89-3	-	-	16-Jan-2020	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	ECHA_01_2020.pdf	Details
Pentazinc chromate octahydroxide	256-418-0	49663-84-5	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Pentalead tetraoxide sulphate	235-067-7	12065-90-6	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Pentadecafluorooctanoic acid (PFOA)	206-397-9	335-67-1	20-Jun-2013	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/69/2013	Details
Pentacosafluorotridecanoic acid	276-745-2	72629-94-8	19-Dec-2012	vPvB (Article 57e)	ED/169/2012	Details
p-(1,1-dimethylpropyl)phenol	201-280-9	80-46-6	12-Jan-2017	Endocrine disrupting properties (Article 57(f) - environment)	ED/01/2017	Details
orthoboric acid, sodium salt show/hide Boric acid, sodium salt EC No.: 215-604-1 \| CAS No.: 1333-73-9 Orthoboric acid, sodium salt EC No.: 237-560-2 \| CAS No.: 13840-56-7 boric acid (H3BO3), sodium salt, hydrate EC No.: - \| CAS No.: 25747-83-5 boric acid (H3BO3), sodium salt (1:1) EC No.: - \| CAS No.: 14890-53-0 Boric acid (H3BO3), disodium salt EC No.: - \| CAS No.: 22454-04-2 Trisodium orthoborate EC No.: 238-253-6 \| CAS No.: 14312-40-4	-	-	08-Jul-2021	Toxic for reproduction (Article 57c)	D(2021)4569-DC	Details
Orange lead (lead tetroxide)	215-235-6	1314-41-6	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Octamethylcyclotetrasiloxane D4	209-136-7	556-67-2	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
o-toluidine	202-429-0	95-53-4	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
o-aminoazotoluene	202-591-2	97-56-3	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
Nonadecafluorodecanoic acid (PFDA) and its sodium and ammonium salts show/hide Nonadecafluorodecanoic acid EC No.: 206-400-3 \| CAS No.: 335-76-2 sodium nonadecafluorodecanoate EC No.: - \| CAS No.: 3830-45-3 Ammonium nonadecafluorodecanoate EC No.: 221-470-5 \| CAS No.: 3108-42-7	-	-	12-Jan-2017	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/01/2017	Details
Nitrobenzene	202-716-0	98-95-3	17-Dec-2015	Toxic for reproduction (Article 57c)	ED/79/2015	Details
n-pentyl-isopentyl phthalate	-	776297-69-9	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
N-methylacetamide	201-182-6	79-16-3	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
N-(hydroxymethyl)acrylamide	213-103-2	924-42-5	10-Jun-2022	Carcinogenic (Article 57a) Mutagenic (Article 57b)	D(2022)4187-DC	Details
N,N-dimethylformamide	200-679-5	68-12-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
N,N-dimethylacetamide	204-826-4	127-19-5	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
N,N,N',N'-tetramethyl-4,4'-methylenedianiline (Michler’s base)	202-959-2	101-61-1	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
Methyloxirane (Propylene oxide)	200-879-2	75-56-9	19-Dec-2012	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/169/2012	Details
Methoxyacetic acid	210-894-6	625-45-6	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Melamine	203-615-4	108-78-1	17-Jan-2023	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2022)9120-DC	Details
Medium-chain chlorinated paraffins (MCCP) UVCB substances consisting of more than or equal to 80% linear chloroalkanes with carbon chain lengths within the range from C14 to C17 show/hide Alkanes, C14-16, chloro EC No.: - \| CAS No.: 1372804-76-6 di-, tri- and tetrachlorotetradecane EC No.: - \| CAS No.: - Alkanes, C14-17, chloro EC No.: 287-477-0 \| CAS No.: 85535-85-9 Tetradecane, chloro derivs. EC No.: - \| CAS No.: 198840-65-2	-	-	08-Jul-2021	PBT (Article 57d) vPvB (Article 57e)	D(2021)4569-DC	Details
Lead(II) bis(methanesulfonate) -	401-750-5	17570-76-2	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
Lead titanium zirconium oxide	235-727-4	12626-81-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead titanium trioxide	235-038-9	12060-00-3	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead sulfochromate yellow (C.I. Pigment Yellow 34) -	215-693-7	1344-37-2	13-Jan-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/68/2009	Details
Lead styphnate	239-290-0	15245-44-0	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
Lead oxide sulfate	234-853-7	12036-76-9	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead monoxide (lead oxide)	215-267-0	1317-36-8	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead hydrogen arsenate	232-064-2	7784-40-9	28-Oct-2008	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/67/2008	Details
Lead dipicrate	229-335-2	6477-64-1	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
Lead dinitrate	233-245-9	10099-74-8	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead diazide, Lead azide	236-542-1	13424-46-9	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
Lead di(acetate)	206-104-4	301-04-2	16-Dec-2013	Toxic for reproduction (Article 57c)	ED/121/2013	Details
Lead cyanamidate	244-073-9	20837-86-9	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead chromate molybdate sulphate red (C.I. Pigment Red 104) -	235-759-9	12656-85-8	13-Jan-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/68/2009	Details
Lead chromate	231-846-0	7758-97-6	13-Jan-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/68/2009	Details
Lead bis(tetrafluoroborate)	237-486-0	13814-96-5	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead	231-100-4	7439-92-1	27-Jun-2018	Toxic for reproduction (Article 57c)	ED/61/2018	Details
Isobutyl 4-hydroxybenzoate	224-208-8	4247-02-3	17-Jan-2023	Endocrine disrupting properties (Article 57(f) - human health)	D(2022)9120-DC	Details
Imidazolidine-2-thione (2-imidazoline-2-thiol)	202-506-9	96-45-7	16-Dec-2013	Toxic for reproduction (Article 57c)	ED/121/2013	Details
Hydrazine	206-114-9	302-01-2, 7803-57-8	20-Jun-2011	Carcinogenic (Article 57a)	ED/31/2011	Details
Hexahydromethylphthalic anhydride including cis- and trans- stereo isomeric forms and all possible combinations of the isomers show/hide Hexahydro-1-methylphthalic anhydride EC No.: 256-356-4 \| CAS No.: 48122-14-1 Hexahydro-3-methylphthalic anhydride EC No.: 260-566-1 \| CAS No.: 57110-29-9 Hexahydro-4-methylphthalic anhydride EC No.: 243-072-0 \| CAS No.: 19438-60-9 Hexahydromethylphthalic anhydride EC No.: 247-094-1 \| CAS No.: 25550-51-0	-	-	19-Dec-2012	Respiratory sensitising properties (Article 57(f) - human health)	ED/169/2012	Details
Hexabromocyclododecane (HBCDD) and all major diastereoisomers identified show/hide 1,2,5,6,9,10-hexabromocyclododecane EC No.: 221-695-9 \| CAS No.: 3194-55-6 Hexabromocyclododecane EC No.: 247-148-4 \| CAS No.: 25637-99-4 alpha-hexabromocyclododecane EC No.: - \| CAS No.: 134237-50-6 beta-hexabromocyclododecane EC No.: - \| CAS No.: 134237-51-7 gamma-hexabromocyclododecane EC No.: - \| CAS No.: 134237-52-8	-	-	28-Oct-2008	PBT (Article 57d)	ED/67/2008	Details
Heptacosafluorotetradecanoic acid	206-803-4	376-06-7	19-Dec-2012	vPvB (Article 57e)	ED/169/2012	Details
Henicosafluoroundecanoic acid	218-165-4	2058-94-8	19-Dec-2012	vPvB (Article 57e)	ED/169/2012	Details
glutaral	203-856-5	111-30-8	08-Jul-2021	Respiratory sensitising properties (Article 57(f) - human health)	D(2021)4569-DC	Details
Furan	203-727-3	110-00-9	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
Formamide	200-842-0	75-12-7	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
Formaldehyde, oligomeric reaction products with aniline	500-036-1	25214-70-4	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Fluoranthene	205-912-4	206-44-0	15-Jan-2019	PBT (Article 57d) vPvB (Article 57e)	ED/88/2018	Details
Fatty acids, C16-18, lead salts	292-966-7	91031-62-8	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Ethylenediamine EDA	203-468-6	107-15-3	27-Jun-2018	Respiratory sensitising properties (Article 57(f) - human health)	ED/61/2018	Details
Dodecamethylcyclohexasiloxane D6	208-762-8	540-97-6	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Disodium tetraborate, anhydrous	215-540-4	12179-04-3, 1303-96-4, 1330-43-4	18-Jun-2010	Toxic for reproduction (Article 57c)	ED/30/2010	Details
Disodium octaborate	234-541-0	12008-41-2	27-Jun-2018	Toxic for reproduction (Article 57c)	ED/61/2018	Details
Disodium 4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo] -5-hydroxy-6-(phenylazo)naphthalene-2,7-disulphonate (C.I. Direct Black 38)	217-710-3	1937-37-7	16-Dec-2013	Carcinogenic (Article 57a)	ED/121/2013	Details
Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate) (C.I. Direct Red 28)	209-358-4	573-58-0	16-Dec-2013	Carcinogenic (Article 57a)	ED/121/2013	Details
Dipentyl phthalate (DPP)	205-017-9	131-18-0	20-Jun-2013	Toxic for reproduction (Article 57c)	ED/69/2013	Details
Dioxobis(stearato)trilead	235-702-8	12578-12-0	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Dioctyltin dilaurate, stannane, dioctyl-, bis(coco acyloxy) derivs., and any other stannane, dioctyl-, bis(fatty acyloxy) derivs. wherein C12 is the predominant carbon number of the fatty acyloxy moiety show/hide dioctyltin dilaurate; stannane, dioctyl-, bis(coco acyloxy) derivs. EC No.: - \| CAS No.: - Stannane, dioctyl-, bis(coco acyloxy) derivs. EC No.: 293-901-5 \| CAS No.: 91648-39-4 Dioctyltin dilaurate EC No.: 222-883-3 \| CAS No.: 3648-18-8	-	-	19-Jan-2021	Toxic for reproduction (Article 57c)	D(2020)9139-DC	Details
Dinoseb (6-sec-butyl-2,4-dinitrophenol)	201-861-7	88-85-7	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Dimethyl sulphate	201-058-1	77-78-1	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
Diisopentyl phthalate	210-088-4	605-50-5	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Diisohexyl phthalate	276-090-2	71850-09-4	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details
Diisobutyl phthalate	201-553-2	84-69-5	13-Jan-2010	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/30/2017 ED/68/2009	Details
Dihexyl phthalate	201-559-5	84-75-3	16-Dec-2013	Toxic for reproduction (Article 57c)	ED/121/2013	Details
Diethyl sulphate	200-589-6	64-67-5	19-Dec-2012	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/169/2012	Details
Dicyclohexyl phthalate DCHP	201-545-9	84-61-7	27-Jun-2018	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2018/636 ED/61/2018	Details
Dichromium tris(chromate)	246-356-2	24613-89-6	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Dibutyltin dichloride (DBTC)	211-670-0	683-18-1	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Dibutylbis(pentane-2,4-dionato-O,O')tin	245-152-0	22673-19-4	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
Dibutyl phthalate (DBP)	201-557-4	84-74-2	28-Oct-2008	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/30/2017 ED/67/2008	Details
Diboron trioxide	215-125-8	1303-86-2	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
Diazene-1,2-dicarboxamide (C,C'-azodi(formamide)) (ADCA)	204-650-8	123-77-3	19-Dec-2012	Respiratory sensitising properties (Article 57(f) - human health)	ED/169/2012	Details
Diarsenic trioxide	215-481-4	1327-53-3	28-Oct-2008	Carcinogenic (Article 57a)	ED/67/2008	Details
Diarsenic pentaoxide	215-116-9	1303-28-2	28-Oct-2008	Carcinogenic (Article 57a)	ED/67/2008	Details
Decamethylcyclopentasiloxane D5	208-764-9	541-02-6	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Cyclohexane-1,2-dicarboxylic anhydride all possible combinations of the cis- and trans-isomers show/hide cis-cyclohexane-1,2-dicarboxylic anhydride EC No.: 236-086-3 \| CAS No.: 13149-00-3 Cyclohexane-1,2-dicarboxylic anhydride EC No.: 201-604-9 \| CAS No.: 85-42-7 trans-cyclohexane-1,2-dicarboxylic anhydride EC No.: 238-009-9 \| CAS No.: 14166-21-3	-	-	19-Dec-2012	Respiratory sensitising properties (Article 57(f) - human health)	ED/169/2012	Details
Cobalt(II) sulphate	233-334-2	10124-43-3	15-Dec-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/95/2010	Details
Cobalt(II) dinitrate	233-402-1	10141-05-6	15-Dec-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/95/2010	Details
Cobalt(II) diacetate	200-755-8	71-48-7	15-Dec-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/95/2010	Details
Cobalt(II) carbonate	208-169-4	513-79-1	15-Dec-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/95/2010	Details
Cobalt dichloride	231-589-4	7646-79-9	28-Oct-2008	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/31/2011 ED/67/2008	Details
Chrysene	205-923-4	218-01-9	15-Jan-2018	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/01/2018	Details
Chromium trioxide	215-607-8	1333-82-0	15-Dec-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/95/2010	Details
Calcium arsenate	231-904-5	7778-44-1	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Cadmium sulphide	215-147-8	1306-23-6	16-Dec-2013	Carcinogenic (Article 57a) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/121/2013	Details
Cadmium sulphate	233-331-6	10124-36-4, 31119-53-6	17-Dec-2014	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/108/2014	Details
Cadmium oxide	215-146-2	1306-19-0	20-Jun-2013	Carcinogenic (Article 57a) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/69/2013	Details
Cadmium nitrate	233-710-6	10325-94-7	15-Jan-2018	Carcinogenic (Article 57a) Mutagenic (Article 57b) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/01/2018	Details
Cadmium hydroxide	244-168-5	21041-95-2	15-Jan-2018	Carcinogenic (Article 57a) Mutagenic (Article 57b) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/01/2018	Details
Cadmium fluoride	232-222-0	7790-79-6	17-Dec-2014	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/108/2014	Details
Cadmium chloride	233-296-7	10108-64-2	16-Jun-2014	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/49/2014	Details
Cadmium carbonate	208-168-9	513-78-0	15-Jan-2018	Carcinogenic (Article 57a) Mutagenic (Article 57b) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/01/2018	Details
Cadmium	231-152-8	7440-43-9	20-Jun-2013	Carcinogenic (Article 57a) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/69/2013	Details
Butyl 4-hydroxybenzoate	202-318-7	94-26-8	25-Jun-2020	Endocrine disrupting properties (Article 57(f) - human health)	D(2020)4578-DC	Details
Boric acid EC No. 233-139-2 and EC No. 234-343-4 show/hide Boric acid EC No.: 233-139-2 \| CAS No.: 10043-35-3 Boric acid, crude natural EC No.: 234-343-4 \| CAS No.: 11113-50-1	-	-	18-Jun-2010	Toxic for reproduction (Article 57c)	ED/30/2010	Details
Bis(tributyltin) oxide (TBTO)	200-268-0	56-35-9	28-Oct-2008	PBT (Article 57d)	ED/67/2008	Details
Bis(pentabromophenyl) ether (decabromodiphenyl ether) (DecaBDE)	214-604-9	1163-19-5	19-Dec-2012	PBT (Article 57d) vPvB (Article 57e)	ED/169/2012	Details
Bis(2-methoxyethyl) phthalate	204-212-6	117-82-8	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
Bis(2-methoxyethyl) ether	203-924-4	111-96-6	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
bis(2-ethylhexyl) tetrabromophthalate covering any of the individual isomers and/or combinations thereof show/hide Bis(2-ethylhexyl) tetrabromophthalate EC No.: 247-426-5 \| CAS No.: 26040-51-7	-	-	17-Jan-2023	vPvB (Article 57e)	D(2022)9120-DC	Details
Bis(2-(2-methoxyethoxy)ethyl)ether	205-594-7	143-24-8	19-Jan-2021	Toxic for reproduction (Article 57c)	D(2020)9139-DC	Details
Bis (2-ethylhexyl)phthalate (DEHP)	204-211-0	117-81-7	28-Oct-2008	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/108/2014 ED/30/2017 ED/67/2008	Details
Biphenyl-4-ylamine	202-177-1	92-67-1	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
Benzyl butyl phthalate (BBP)	201-622-7	85-68-7	28-Oct-2008	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/30/2017 ED/67/2008	Details
Benzo[k]fluoranthene	205-916-6	207-08-9	15-Jan-2019	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/88/2018	Details
Benzo[ghi]perylene	205-883-8	191-24-2	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Benzo[def]chrysene (Benzo[a]pyrene)	200-028-5	50-32-8	20-Jun-2016	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c) PBT (Article 57d) vPvB (Article 57e)	ED/21/2016	Details
Benzene-1,2,4-tricarboxylic acid 1,2 anhydride trimellitic anhydride; TMA	209-008-0	552-30-7	27-Jun-2018	Respiratory sensitising properties (Article 57(f) - human health)	ED/61/2018 EU/2018/594	Details
Benz[a]anthracene	200-280-6	56-55-3	15-Jan-2018	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/01/2018	Details
Barium diboron tetraoxide	237-222-4	13701-59-2	17-Jan-2023	Toxic for reproduction (Article 57c)	D(2022)9120-DC	Details
Arsenic acid	231-901-9	7778-39-4	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Anthracene oil, anthracene-low -	292-604-8	90640-82-7	13-Jan-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Anthracene oil, anthracene paste, distn. lights -	295-278-5	91995-17-4	13-Jan-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Anthracene oil, anthracene paste, anthracene fraction -	295-275-9	91995-15-2	13-Jan-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Anthracene oil, anthracene paste -	292-603-2	90640-81-6	13-Jan-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Anthracene oil -	292-602-7	90640-80-5	13-Jan-2010	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Anthracene	204-371-1	120-12-7	28-Oct-2008	PBT (Article 57d)	ED/67/2008	Details
Ammonium pentadecafluorooctanoate (APFO)	223-320-4	3825-26-1	20-Jun-2013	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/69/2013	Details
Ammonium dichromate	232-143-1	7789-09-5	18-Jun-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c)	ED/30/2010	Details
Aluminosilicate Refractory Ceramic Fibres are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium and silicon are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm) c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight show/hide Refractories, fibers, aluminosilicate EC No.: - \| CAS No.: 142844-00-6	-	-	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011 ED/95/2012	Details
Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins)	287-476-5	85535-84-8	28-Oct-2008	PBT (Article 57d) vPvB (Article 57e)	ED/67/2008	Details
Acrylamide	201-173-7	79-06-1	30-Mar-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/68/2009	Details
Acids generated from chromium trioxide and their oligomers show/hide Chromic acid EC No.: 231-801-5 \| CAS No.: 7738-94-5 Oligomers of chromic acid and dichromic acid EC No.: - \| CAS No.: - Dichromic acid EC No.: 236-881-5 \| CAS No.: 13530-68-2	-	-	15-Dec-2010	Carcinogenic (Article 57a)	ED/95/2010	Details
Acetic acid, lead salt, basic	257-175-3	51404-69-4	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
[Phthalato(2-)]dioxotrilead	273-688-5	69011-06-9	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
[4-[[4-anilino-1-naphthyl][4-(dimethylamino)phenyl]methylene]cyclohexa-2,5-dien-1-ylidene] dimethylammonium chloride (C.I. Basic Blue 26) with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)	219-943-6	2580-56-5	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
[4-[4,4'-bis(dimethylamino) benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride (C.I. Basic Violet 3) with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)	208-953-6	548-62-9	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
6-methoxy-m-toluidine (p-cresidine)	204-419-1	120-71-8	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol	204-327-1	119-47-1	17-Jan-2022	Toxic for reproduction (Article 57c)	D(2021)10043-DC	Details
5-tert-butyl-2,4,6-trinitro-m-xylene (Musk xylene)	201-329-4	81-15-2	28-Oct-2008	vPvB (Article 57e)	ED/67/2008	Details
5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [1], 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [2] covering any of the individual stereoisomers of [1] and [2] or any combination thereof show/hide Reaction mass of 5-[(2R)-butan-2-yl]-2-[(1R,2R)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2R)-butan-2-yl]-2-[(1R,6R)-4,6-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2S)-butan-2-yl]-2-[(1R,2R)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2S)-butan-2-yl]-2-[(1S,2R)-2,4-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane and 5-[(2S)-butan-2-yl]-2-[(1S,6R)-4,6-dimethylcyclohex-3-en-1-yl]-5-methyl-1,3-dioxane EC No.: - \| CAS No.: - 1,3-Dioxane, 2-(2,4-dimethyl-3-cyclohexen-1-yl)-5-methyl-5-(1-methylpropyl)- EC No.: - \| CAS No.: 117933-89-8 1,3-Dioxane, 2-[(1R,2R)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, cis- EC No.: - \| CAS No.: 676367-05-8 1,3-Dioxane, 2-[(1R,2R)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, cis-rel- EC No.: - \| CAS No.: 343934-04-3 1,3-Dioxane, 2-[(1R,2R)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, trans- EC No.: - \| CAS No.: 676367-09-2 1,3-Dioxane, 2-[(1R,2R)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, trans-rel- EC No.: - \| CAS No.: 343934-05-4 1,3-Dioxane, 2-[(1R,2S)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, cis- EC No.: - \| CAS No.: 676367-04-7 1,3-Dioxane, 2-[(1R,2S)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, trans- EC No.: - \| CAS No.: 676367-08-1 1,3-Dioxane, 2-[(1S,2R)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, cis- EC No.: - \| CAS No.: 676367-03-6 1,3-Dioxane, 2-[(1S,2R)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, trans- EC No.: - \| CAS No.: 676367-07-0 1,3-Dioxane, 2-[(1S,2S)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, cis- EC No.: - \| CAS No.: 676367-02-5 1,3-Dioxane, 2-[(1S,2S)-2,4-dimethyl-3-cyclohexen-1-yl]-5-methyl-5-(1-methylpropyl)-, trans- EC No.: - \| CAS No.: 676367-06-9 5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane EC No.: - \| CAS No.: - 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane EC No.: - \| CAS No.: - Reaction mass of 5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane and 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane EC No.: 413-720-9 \| CAS No.: - 1,3-Dioxane, 2-(2,4-dimethyl-3-cyclohexen-1-yl)-5-methyl-5-(1-methylpropyl)- EC No.: - \| CAS No.: 186309-28-4	-	-	15-Jun-2015	vPvB (Article 57e)	ED/39/2015	Details
4-tert-butylphenol	202-679-0	98-54-4	16-Jul-2019	Endocrine disrupting properties (Article 57(f) - environment)	ED/71/2019 EU/2019/1194	Details
4-Nonylphenol, branched and linear, ethoxylated substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof show/hide Nonylphenol, ethoxylated EC No.: 500-024-6 \| CAS No.: 9016-45-9 2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethanol EC No.: 230-770-5 \| CAS No.: 7311-27-5 26-(4-Nonylphenoxy)-3,6,9,12,15,18,21,24- octaoxahexacosan -1-ol EC No.: - \| CAS No.: 14409-72-4 2-[2-(4-nonylphenoxy)ethoxy]ethanol EC No.: 243-816-4 \| CAS No.: 20427-84-3 Nonylphenol, branched, ethoxylated 1 - 2.5 moles ethoxylated EC No.: 500-209-1 \| CAS No.: 68412-54-4 4-Nonylphenol, ethoxylated 1 - 2.5 moles ethoxylated EC No.: 500-045-0 \| CAS No.: 26027-38-3 Nonylphenol, ethoxylated (6,5-EO) EC No.: - \| CAS No.: 9016-45-9 Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched EC No.: - \| CAS No.: 68412-54-4 20-(4-nonylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol EC No.: 248-743-1 \| CAS No.: 27942-27-4 Nonylphenol, ethoxylated (15-EO) EC No.: - \| CAS No.: 9016-45-9 Nonylphenol, ethoxylated (10-EO) EC No.: - \| CAS No.: 9016-45-9 Nonylphenol, ethoxylated (8-EO) EC No.: - \| CAS No.: 9016-45-9 Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy-, branched EC No.: - \| CAS No.: 68412-54-4 29-(nonylphenoxy)-3,6,9,12,15,18,21,24,27-nonaoxanonacosanol EC No.: 248-294-1 \| CAS No.: 27177-08-8 2-(nonylphenoxy)ethanol EC No.: 248-762-5 \| CAS No.: 27986-36-3 4-t-Nonylphenol-diethoxylate EC No.: - \| CAS No.: 156609-10-8 3,6,9,12-Tetraoxatetradecan-1-ol, 14-(4-nonylphenoxy)- EC No.: - \| CAS No.: 20636-48-0 3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-(nonylphenoxy)- EC No.: - \| CAS No.: 27177-01-1 3,6,9,12,15,18,21,24,27-Nonaoxanonacosan-1-ol, 29-(isononylphenoxy)- EC No.: - \| CAS No.: 65455-72-3 Poly(oxy-1,2-ethanediyl), α-(nonylphenyl)-ω-hydroxy- EC No.: - \| CAS No.: 9016-45-9 4-Nonylphenol, branched, ethoxylated EC No.: - \| CAS No.: 127087-87-0 Nonylphenolpolyglycolether EC No.: - \| CAS No.: - 2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethanol EC No.: - \| CAS No.: 1119449-37-4 2-{2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethoxy}ethanol EC No.: - \| CAS No.: 1119449-38-5 Nonylphenol, ethoxylated (polymer) EC No.: - \| CAS No.: - Nonylphenol, ethoxylated (EO = 4) EC No.: - \| CAS No.: - Nonylphenol, ethoxylated (EO = 10) EC No.: - \| CAS No.: - 23-(nonylphenoxy)-3,6,9,12,15,18,21-heptaoxatricosan-1-ol EC No.: 248-293-6 \| CAS No.: 27177-05-5 20-(nonylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol EC No.: 248-292-0 \| CAS No.: 27177-03-3 2-[2-(nonylphenoxy)ethoxy]ethanol EC No.: 248-291-5 \| CAS No.: 27176-93-8 26-(nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol EC No.: 247-816-5 \| CAS No.: 26571-11-9 14-(nonylphenoxy)-3,6,9,12-tetraoxatetradecan-1-ol EC No.: 247-555-7 \| CAS No.: 26264-02-8 Isononylphenol, ethoxylated EC No.: - \| CAS No.: 37205-87-1 17-(4-nonylphenoxy)-3,6,9,12,15-pentaoxaheptadecan-1-ol EC No.: - \| CAS No.: 34166-38-6 4-Nonylphenol, branched, ethoxylated 1 - 2.5 moles ethoxylated EC No.: 500-315-8 \| CAS No.: 127087-87-0 3,6,9,12-Tetraoxatetradecan-1-ol, 14-(4-nonylphenoxy)-, branched EC No.: 293-926-1 \| CAS No.: 91648-64-5 2-(isononylphenoxy)ethanol EC No.: 284-987-5 \| CAS No.: 85005-55-6 20-(isononylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol EC No.: 265-785-6 \| CAS No.: 65455-69-8 2-(4-nonylphenoxy)ethanol EC No.: 881-745-6 \| CAS No.: 104-35-8 26-(nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol; EC No.: 255-695-5 \| CAS No.: 42173-90-0 44-(nonylphenoxy)-3,6,9,12,15,18,21,24,27,30,33,36,39,42-tetradecaoxatetratetracontanol EC No.: 260-678-0 \| CAS No.: 57321-10-5	-	-	20-Jun-2013	Endocrine disrupting properties (Article 57(f) - environment)	ED/69/2013	Details
4-Nonylphenol, branched and linear substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof show/hide 4-(1-Ethyl-1,4-dimethylpentyl)phenol EC No.: - \| CAS No.: 142731-63-3 4-(1-Ethyl-1,3-dimethylpentyl)phenol EC No.: - \| CAS No.: 186825-36-5 p-(1-methyloctyl)phenol EC No.: 241-427-4 \| CAS No.: 17404-66-9 p-(1,1-dimethylheptyl)phenol EC No.: 250-339-5 \| CAS No.: 30784-30-6 p-nonylphenol EC No.: 203-199-4 \| CAS No.: 104-40-5 4-(1-ethyl-1-methylhexyl)phenol EC No.: 257-907-1 \| CAS No.: 52427-13-1 Phenol, 4-nonyl-, branched EC No.: 284-325-5 \| CAS No.: 84852-15-3 p-isononylphenol EC No.: 247-770-6 \| CAS No.: 26543-97-5 4-(1,1,5-Trimethylhexyl)phenol EC No.: - \| CAS No.: 521947-27-3 4-(3-ethylheptan-2-yl)phenol EC No.: - \| CAS No.: 186825-39-8 Isononylphenol EC No.: 234-284-4 \| CAS No.: 11066-49-2 Phenol, nonyl-, branched EC No.: 291-844-0 \| CAS No.: 90481-04-2 Nonylphenol EC No.: 246-672-0 \| CAS No.: 25154-52-3	-	-	19-Dec-2012	Endocrine disrupting properties (Article 57(f) - environment)	ED/169/2012	Details
4-methyl-m-phenylenediamine (toluene-2,4-diamine)	202-453-1	95-80-7	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
4-heptylphenol, branched and linear substances with a linear and/or branched alkyl chain with a carbon number of 7 covalently bound predominantly in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof show/hide 4-heptylphenol EC No.: 217-862-0 \| CAS No.: 1987-50-4 Phenol, heptyl derivs. EC No.: 276-743-1 \| CAS No.: 72624-02-3 4-(3-ethylpentan-3-yl)phenol EC No.: - \| CAS No.: 37872-24-5 4-(2-methylhexan-2-yl)phenol EC No.: - \| CAS No.: 30784-31-7 4-(3,3-dimethylpentan-2-yl)phenol EC No.: - \| CAS No.: 911371-06-7 4-(3-methylhexan-2-yl)phenol EC No.: - \| CAS No.: 854904-93-1 4-(4,4-dimethylpentan-2-yl)phenol EC No.: - \| CAS No.: 911371-07-8 4-(4-methylhexan-2-yl)phenol EC No.: - \| CAS No.: 71945-81-8 4-(5-methylhexan-2-yl)phenol EC No.: - \| CAS No.: 857629-71-1 4-(2,2-dimethylpentan-3-yl)phenol EC No.: - \| CAS No.: 861010-65-3 Phenol, 4-(1-ethyl-1,2-dimethylpropyl)- EC No.: - \| CAS No.: 30784-27-1 4-(heptan-3-yl)phenol EC No.: - \| CAS No.: 6465-74-3 4-(heptan-2-yl)phenol EC No.: - \| CAS No.: 6863-24-7 4-(heptan-4-yl)phenol EC No.: - \| CAS No.: 6465-71-0 4-(3-ethylpentyl)phenol EC No.: - \| CAS No.: 911370-98-4 4-(3-methylhexyl)phenol EC No.: - \| CAS No.: 102570-52-5 4-(4-methylhexyl)phenol EC No.: - \| CAS No.: 1139800-98-8 4-(5-methylhexyl)phenol EC No.: - \| CAS No.: 100532-36-3 4-(2,4-dimethylpentan-3-yl)phenol EC No.: - \| CAS No.: 1824346-00-0 Phenol, 4-tert-heptyl- EC No.: - \| CAS No.: 288864-02-8 4-(2,3-dimethylpentan-2-yl)phenol EC No.: - \| CAS No.: 861011-60-1 4-(3-methylhexan-3-yl)phenol EC No.: - \| CAS No.: 30784-32-8 4-(2,4-dimethylpentan-2-yl)phenol EC No.: - \| CAS No.: 33104-11-9 4-(2,3,3-trimethylbutan-2-yl)phenol EC No.: - \| CAS No.: 72861-06-4 4-(5-methylhexan-3-yl)phenol EC No.: - \| CAS No.: 854904-92-0	-	-	12-Jan-2017	Endocrine disrupting properties (Article 57(f) - environment)	ED/01/2017	Details
4-aminoazobenzene	200-453-6	60-09-3	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
4-(1,1,3,3-tetramethylbutyl)phenol, ethoxylated covering well-defined substances and UVCB substances, polymers and homologues show/hide 20-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3,6,9,12,15,18-hexaoxaicosan-1-ol EC No.: 219-682-8 \| CAS No.: 2497-59-8 Poly(oxy-1,2-ethanediyl), α-[(1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxy- EC No.: - \| CAS No.: 9036-19-5 2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethanol EC No.: - \| CAS No.: 2315-67-5 2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethanol EC No.: - \| CAS No.: 2315-61-9 Polyethylene glycol p-(1,1,3,3-tetramethylbutyl)phenyl ether EC No.: - \| CAS No.: 9002-93-1	-	-	19-Dec-2012	Endocrine disrupting properties (Article 57(f) - environment)	ED/169/2012	Details
4-(1,1,3,3-tetramethylbutyl)phenol	205-426-2	140-66-9	19-Dec-2011	Endocrine disrupting properties (Article 57(f) - environment)	ED/77/2011	Details
4,4'-sulphonyldiphenol	201-250-5	80-09-1	17-Jan-2023	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	D(2022)9120-DC	Details
4,4'-oxydianiline and its salts show/hide 4,4'-oxydianiline EC No.: 202-977-0 \| CAS No.: 101-80-4	-	-	19-Dec-2012	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/169/2012	Details
4,4'-methylenedi-o-toluidine	212-658-8	838-88-0	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
4,4'-isopropylidenediphenol Bisphenol A; BPA	201-245-8	80-05-7	12-Jan-2017	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	ED/30/2017 ED/01/2017 ED 01/2018	Details
4,4'-bis(dimethylamino)benzophenone (Michler’s ketone)	202-027-5	90-94-8	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
4,4'-bis(dimethylamino)-4''-(methylamino)trityl alcohol with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)	209-218-2	561-41-1	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
4,4'-(1-methylpropylidene)bisphenol	201-025-1	77-40-7	08-Jul-2021	Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	D(2021)4569-DC	Details
4,4'- Diaminodiphenylmethane (MDA)	202-974-4	101-77-9	28-Oct-2008	Carcinogenic (Article 57a)	ED/67/2008	Details
3-ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine ZOLDINE MS-PLUS	421-150-7	143860-04-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
2-methylimidazole	211-765-7	693-98-1	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one ACETOCURE 97; GENOCURE*PMP; IGM 4817; IRGACURE 907; SPEEDCURE 97	400-600-6	71868-10-5	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details
2-methoxyethyl acetate	203-772-9	110-49-6	16-Jul-2019	Toxic for reproduction (Article 57c)	ED/71/2019	Details
2-methoxyethanol	203-713-7	109-86-4	15-Dec-2010	Toxic for reproduction (Article 57c)	ED/95/2010	Details
2-Methoxyaniline, o-Anisidine	201-963-1	90-04-0	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (DOTE)	239-622-4	15571-58-1	17-Dec-2014	Toxic for reproduction (Article 57c)	ED/108/2014	Details
2-ethoxyethyl acetate	203-839-2	111-15-9	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
2-ethoxyethanol	203-804-1	110-80-5	15-Dec-2010	Toxic for reproduction (Article 57c)	ED/95/2010	Details

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Candidate List of substances of very high concern for Authorisation

Candidate List of substances of very high concern for Authorisation

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Candidate List of substances of very high concern for Authorisation

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