Candidate List of substances of very high concern for Authorisation

(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

Notes:

Authentic version: Only the Candidate List published on this website is deemed authentic. Companies may have immediate legal obligations following the inclusion of a substance in the Candidate List on this website including in particular Articles 7, 31 and 33 of the REACH Regulation.
Numerical identifiers: Each candidate list entry covers both anhydrous and hydrated forms of a substance. The CAS number shown in an entry is typically for the anhydrous form. Hydrated forms of the substance identified by other CAS numbers are still within the scope of the entry.
Other numerical identifiers: For those entries with "-" in the EC number and CAS number columns, a non-exhaustive inventory of EC and/or CAS Registry numbers describing substances or groups of substances considered to fall within the scope of the Candidate List entry is included, where practicably possible. This information can be accessed through the "Details" button of the selected entry.

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Showing 1 - 200 of 235 results.

Substance name	EC No.	CAS No.	Date of inclusion	Reason for inclusion	Decision
Nitrobenzene	202-716-0	98-95-3	17-Dec-2015	Toxic for reproduction (Article 57c)	ED/79/2015	Details
4-tert-butylphenol	202-679-0	98-54-4	16-Jul-2019	Endocrine disrupting properties (Article 57(f) - environment)	ED/71/2019 EU/2019/1194	Details
o-aminoazotoluene	202-591-2	97-56-3	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
Imidazolidine-2-thione (2-imidazoline-2-thiol)	202-506-9	96-45-7	16-Dec-2013	Toxic for reproduction (Article 57c)	ED/121/2013	Details
1,2,3-trichloropropane	202-486-1	96-18-4	20-Jun-2011	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/31/2011	Details
4-methyl-m-phenylenediamine (toluene-2,4-diamine)	202-453-1	95-80-7	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
o-toluidine	202-429-0	95-53-4	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
Butyl 4-hydroxybenzoate	202-318-7	94-26-8	25-Jun-2020	Endocrine disrupting properties (Article 57(f) - human health)	D(2020)4578-DC	Details
N-(hydroxymethyl)acrylamide	213-103-2	924-42-5	10-Jun-2022	Carcinogenic (Article 57a) Mutagenic (Article 57b)	D(2022)4187-DC	Details
Biphenyl-4-ylamine	202-177-1	92-67-1	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
Anthracene oil, anthracene paste, distn. lights -	295-278-5	91995-17-4	13-Jan-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Anthracene oil, anthracene paste, anthracene fraction -	295-275-9	91995-15-2	13-Jan-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Fatty acids, C16-18, lead salts	292-966-7	91031-62-8	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Anthracene oil, anthracene-low -	292-604-8	90640-82-7	13-Jan-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Anthracene oil, anthracene paste -	292-603-2	90640-81-6	13-Jan-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Anthracene oil -	292-602-7	90640-80-5	13-Jan-2010	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
4,4'-bis(dimethylamino)benzophenone (Michler’s ketone)	202-027-5	90-94-8	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
2-Methoxyaniline, o-Anisidine	201-963-1	90-04-0	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Dinoseb (6-sec-butyl-2,4-dinitrophenol)	201-861-7	88-85-7	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
1-Methyl-2-pyrrolidone (NMP)	212-828-1	872-50-4	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins)	287-476-5	85535-84-8	28-Oct-2008	PBT (Article 57d) vPvB (Article 57e)	ED/67/2008	Details
Benzyl butyl phthalate (BBP)	201-622-7	85-68-7	28-Oct-2008	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/30/2017 ED/67/2008	Details
Phenanthrene	201-581-5	85-01-8	15-Jan-2019	vPvB (Article 57e)	ED/88/2018	Details
1,2-Benzenedicarboxylic acid, dipentyl ester, branched and linear	284-032-2	84777-06-0	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Dihexyl phthalate	201-559-5	84-75-3	16-Dec-2013	Toxic for reproduction (Article 57c)	ED/121/2013	Details
Dibutyl phthalate (DBP)	201-557-4	84-74-2	28-Oct-2008	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/30/2017 ED/67/2008	Details
Diisobutyl phthalate	201-553-2	84-69-5	13-Jan-2010	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/30/2017 ED/68/2009	Details
Dicyclohexyl phthalate DCHP	201-545-9	84-61-7	27-Jun-2018	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2018/636 ED/61/2018	Details
4,4'-methylenedi-o-toluidine	212-658-8	838-88-0	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
5-tert-butyl-2,4,6-trinitro-m-xylene (Musk xylene)	201-329-4	81-15-2	28-Oct-2008	vPvB (Article 57e)	ED/67/2008	Details
Pyrochlore, antimony lead yellow -	232-382-1	8012-00-8	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
p-(1,1-dimethylpropyl)phenol	201-280-9	80-46-6	12-Jan-2017	Endocrine disrupting properties (Article 57(f) - environment)	ED/01/2017	Details
4,4'-sulphonyldiphenol	201-250-5	80-09-1	17-Jan-2023	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	D(2022)9120-DC	Details
bis(4-chlorophenyl) sulphone	201-247-9	80-07-9	14-Jun-2023	vPvB (Article 57e)	D(2023)3788-DC	Details
4,4'-isopropylidenediphenol Bisphenol A; BPA	201-245-8	80-05-7	12-Jan-2017	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	ED/30/2017 ED/01/2017 ED 01/2018	Details
2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol	201-236-9	79-94-7	17-Jan-2023	Carcinogenic (Article 57a)	D(2022)9120-DC	Details
N-methylacetamide	201-182-6	79-16-3	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Acrylamide	201-173-7	79-06-1	30-Mar-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/68/2009	Details
Trichloroethylene	201-167-4	79-01-6	18-Jun-2010	Carcinogenic (Article 57a)	ED/30/2010	Details
Hydrazine	206-114-9	302-01-2, 7803-57-8	20-Jun-2011	Carcinogenic (Article 57a)	ED/31/2011	Details
Tetraethyllead	201-075-4	78-00-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Cadmium fluoride	232-222-0	7790-79-6	17-Dec-2014	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/108/2014	Details
Sodium dichromate	234-190-3	10588-01-9, 7789-12-0	28-Oct-2008	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c)	ED/67/2008	Details
Ammonium dichromate	232-143-1	7789-09-5	18-Jun-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c)	ED/30/2010	Details
Strontium chromate	232-142-6	7789-06-2	20-Jun-2011	Carcinogenic (Article 57a)	ED/31/2011	Details
Potassium chromate	232-140-5	7789-00-6	18-Jun-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/30/2010	Details
Lead hydrogen arsenate	232-064-2	7784-40-9	28-Oct-2008	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/67/2008	Details
Potassium dichromate	231-906-6	7778-50-9	18-Jun-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c)	ED/30/2010	Details
Calcium arsenate	231-904-5	7778-44-1	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Arsenic acid	231-901-9	7778-39-4	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Sodium chromate	231-889-5	7775-11-3	18-Jun-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c)	ED/30/2010	Details
n-pentyl-isopentyl phthalate	-	776297-69-9	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead chromate	231-846-0	7758-97-6	13-Jan-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/68/2009	Details
Dimethyl sulphate	201-058-1	77-78-1	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
4,4'-(1-methylpropylidene)bisphenol	201-025-1	77-40-7	08-Jul-2021	Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	D(2021)4569-DC	Details
Phenolphthalein	201-004-7	77-09-8	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Cobalt dichloride	231-589-4	7646-79-9	28-Oct-2008	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/31/2011 ED/67/2008	Details
Sodium peroxometaborate	231-556-4	7632-04-4	16-Jun-2014	Toxic for reproduction (Article 57c)	ED/49/2014	Details
diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide	278-355-8	75980-60-8	14-Jun-2023	Toxic for reproduction (Article 57c)	D(2023)3788-DC	Details
Methyloxirane (Propylene oxide)	200-879-2	75-56-9	19-Dec-2012	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/169/2012	Details
Formamide	200-842-0	75-12-7	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
Cadmium	231-152-8	7440-43-9	20-Jun-2013	Carcinogenic (Article 57a) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/69/2013	Details
Lead	231-100-4	7439-92-1	27-Jun-2018	Toxic for reproduction (Article 57c)	ED/61/2018	Details
Pentacosafluorotridecanoic acid	276-745-2	72629-94-8	19-Dec-2012	vPvB (Article 57e)	ED/169/2012	Details
1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7-rich	276-158-1	71888-89-6	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one ACETOCURE 97; GENOCURE*PMP; IGM 4817; IRGACURE 907; SPEEDCURE 97	400-600-6	71868-10-5	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details
Diisohexyl phthalate	276-090-2	71850-09-4	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details
Cobalt(II) diacetate	200-755-8	71-48-7	15-Dec-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/95/2010	Details
2-methylimidazole	211-765-7	693-98-1	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
[Phthalato(2-)]dioxotrilead	273-688-5	69011-06-9	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Silicic acid (H2Si2O5), barium salt (1:1), lead-doped with lead (Pb) content above the applicable generic concentration limit for ’toxicity for reproduction’ Repr. 1A (CLP) or category 1 (DSD),the substance is a member of the group entry of lead compounds, with index number 082-001-00-6 in Regulation (EC) No 1272/2008	272-271-5	68784-75-8	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
1,2-Benzenedicarboxylic acid, dihexyl ester, branched and linear	271-093-5	68515-50-4	16-Jun-2014	Toxic for reproduction (Article 57c)	ED/49/2014	Details
1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters	271-084-6	68515-42-4	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
Dibutyltin dichloride (DBTC)	211-670-0	683-18-1	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
2,2-bis(4'-hydroxyphenyl)-4-methylpentane AP-5	401-720-1	6807-17-6	15-Jan-2019	Toxic for reproduction (Article 57c)	ED/88/2018	Details
N,N-dimethylformamide	200-679-5	68-12-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
α,α-Bis[4-(dimethylamino)phenyl]-4 (phenylamino)naphthalene-1-methanol (C.I. Solvent Blue 4) with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)	229-851-8	6786-83-0	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
Pitch, coal tar, high-temp. -	266-028-2	65996-93-2	13-Jan-2010	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/68/2009	Details
Lead dipicrate	229-335-2	6477-64-1	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
Diethyl sulphate	200-589-6	64-67-5	19-Dec-2012	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/169/2012	Details
1,2-diethoxyethane	211-076-1	629-14-1	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Methoxyacetic acid	210-894-6	625-45-6	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Sulfurous acid, lead salt, dibasic	263-467-1	62229-08-7	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Terphenyl, hydrogenated	262-967-7	61788-32-7	27-Jun-2018	vPvB (Article 57e)	ED/61/2018	Details
Diisopentyl phthalate	210-088-4	605-50-5	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
4-aminoazobenzene	200-453-6	60-09-3	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
1,3,5-tris[(2S and 2R)-2,3-epoxypropyl]-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (β-TGIC) -	423-400-0	59653-74-6	18-Jun-2012	Mutagenic (Article 57b)	ED/87/2012	Details
Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate) (C.I. Direct Red 28)	209-358-4	573-58-0	16-Dec-2013	Carcinogenic (Article 57a)	ED/121/2013	Details
4,4'-bis(dimethylamino)-4''-(methylamino)trityl alcohol with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)	209-218-2	561-41-1	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
Benz[a]anthracene	200-280-6	56-55-3	15-Jan-2018	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/01/2018	Details
Bis(tributyltin) oxide (TBTO)	200-268-0	56-35-9	28-Oct-2008	PBT (Article 57d)	ED/67/2008	Details
Octamethylcyclotetrasiloxane D4	209-136-7	556-67-2	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Benzene-1,2,4-tricarboxylic acid 1,2 anhydride trimellitic anhydride; TMA	209-008-0	552-30-7	27-Jun-2018	Respiratory sensitising properties (Article 57(f) - human health)	ED/61/2018 EU/2018/594	Details
[4-[4,4'-bis(dimethylamino) benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride (C.I. Basic Violet 3) with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)	208-953-6	548-62-9	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
Decamethylcyclopentasiloxane D5	208-764-9	541-02-6	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Dodecamethylcyclohexasiloxane D6	208-762-8	540-97-6	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Acetic acid, lead salt, basic	257-175-3	51404-69-4	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Cobalt(II) carbonate	208-169-4	513-79-1	15-Dec-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/95/2010	Details
Cadmium carbonate	208-168-9	513-78-0	15-Jan-2018	Carcinogenic (Article 57a) Mutagenic (Article 57b) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/01/2018	Details
Benzo[def]chrysene (Benzo[a]pyrene)	200-028-5	50-32-8	20-Jun-2016	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c) PBT (Article 57d) vPvB (Article 57e)	ED/21/2016	Details
Pentazinc chromate octahydroxide	256-418-0	49663-84-5	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Isobutyl 4-hydroxybenzoate	224-208-8	4247-02-3	17-Jan-2023	Endocrine disrupting properties (Article 57(f) - human health)	D(2022)9120-DC	Details
2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol (UV-327)	223-383-8	3864-99-1	17-Dec-2015	vPvB (Article 57e)	ED/79/2015	Details
2-benzotriazol-2-yl-4,6-di-tert-butylphenol (UV-320)	223-346-6	3846-71-7	17-Dec-2014	PBT (Article 57d) vPvB (Article 57e)	ED/108/2014	Details
Ammonium pentadecafluorooctanoate (APFO)	223-320-4	3825-26-1	20-Jun-2013	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/69/2013	Details
1,1'-[ethane-1,2-diylbisoxy]bis[2,4,6-tribromobenzene]	253-692-3	37853-59-1	17-Jan-2023	vPvB (Article 57e)	D(2022)9120-DC	Details
Heptacosafluorotetradecanoic acid	206-803-4	376-06-7	19-Dec-2012	vPvB (Article 57e)	ED/169/2012	Details
Trilead diarsenate	222-979-5	3687-31-8	19-Dec-2011	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/77/2011	Details
2-(2H-benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (UV-350)	253-037-1	36437-37-3	17-Dec-2015	vPvB (Article 57e)	ED/79/2015	Details
Pentadecafluorooctanoic acid (PFOA)	206-397-9	335-67-1	20-Jun-2013	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/69/2013	Details
Cadmium sulphate	233-331-6	10124-36-4, 31119-53-6	17-Dec-2014	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/108/2014	Details
Tricosafluorododecanoic acid	206-203-2	307-55-1	19-Dec-2012	vPvB (Article 57e)	ED/169/2012	Details
Lead di(acetate)	206-104-4	301-04-2	16-Dec-2013	Toxic for reproduction (Article 57c)	ED/121/2013	Details
2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328)	247-384-8	25973-55-1	17-Dec-2014	PBT (Article 57d) vPvB (Article 57e)	ED/108/2014	Details
[4-[[4-anilino-1-naphthyl][4-(dimethylamino)phenyl]methylene]cyclohexa-2,5-dien-1-ylidene] dimethylammonium chloride (C.I. Basic Blue 26) with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)	219-943-6	2580-56-5	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
S-(tricyclo(5.2.1.0'2,6)deca-3-en-8(or 9)-yl O-(isopropyl or isobutyl or 2-ethylhexyl) O-(isopropyl or isobutyl or 2-ethylhexyl) phosphorodithioate X4261	401-850-9	255881-94-8	17-Jan-2022	PBT (Article 57d)	D(2021)10043-DC	Details
Formaldehyde, oligomeric reaction products with aniline	500-036-1	25214-70-4	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Trixylyl phosphate	246-677-8	25155-23-1	16-Dec-2013	Toxic for reproduction (Article 57c)	ED/121/2013	Details
Dichromium tris(chromate)	246-356-2	24613-89-6	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC)	219-514-3	2451-62-9	18-Jun-2012	Mutagenic (Article 57b)	ED/87/2012	Details
Dibutylbis(pentane-2,4-dionato-O,O')tin	245-152-0	22673-19-4	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
Chrysene	205-923-4	218-01-9	15-Jan-2018	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/01/2018	Details
Cadmium hydroxide	244-168-5	21041-95-2	15-Jan-2018	Carcinogenic (Article 57a) Mutagenic (Article 57b) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/01/2018	Details
Lead cyanamidate	244-073-9	20837-86-9	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Benzo[k]fluoranthene	205-916-6	207-08-9	15-Jan-2019	Carcinogenic (Article 57a) PBT (Article 57d) vPvB (Article 57e)	ED/88/2018	Details
Fluoranthene	205-912-4	206-44-0	15-Jan-2019	PBT (Article 57d) vPvB (Article 57e)	ED/88/2018	Details
Henicosafluoroundecanoic acid	218-165-4	2058-94-8	19-Dec-2012	vPvB (Article 57e)	ED/169/2012	Details
Disodium 4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo] -5-hydroxy-6-(phenylazo)naphthalene-2,7-disulphonate (C.I. Direct Black 38)	217-710-3	1937-37-7	16-Dec-2013	Carcinogenic (Article 57a)	ED/121/2013	Details
Benzo[ghi]perylene	205-883-8	191-24-2	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Lead(II) bis(methanesulfonate) -	401-750-5	17570-76-2	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
Triethyl arsenate -	427-700-2	15606-95-8	28-Oct-2008	Carcinogenic (Article 57a)	ED/67/2008	Details
2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (DOTE)	239-622-4	15571-58-1	17-Dec-2014	Toxic for reproduction (Article 57c)	ED/108/2014	Details
Lead styphnate	239-290-0	15245-44-0	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
1,7,7-trimethyl-3-(phenylmethylene)bicyclo[2.2.1]heptan-2-one 3-benzylidene camphor; 3-BC	239-139-9	15087-24-8	15-Jan-2019	Endocrine disrupting properties (Article 57(f) - environment)	ED/88/2018 EU/2018/2013	Details
3-ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine ZOLDINE MS-PLUS	421-150-7	143860-04-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Bis(2-(2-methoxyethoxy)ethyl)ether	205-594-7	143-24-8	19-Jan-2021	Toxic for reproduction (Article 57c)	D(2020)9139-DC	Details
4-(1,1,3,3-tetramethylbutyl)phenol	205-426-2	140-66-9	19-Dec-2011	Endocrine disrupting properties (Article 57(f) - environment)	ED/77/2011	Details
Lead bis(tetrafluoroborate)	237-486-0	13814-96-5	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Barium diboron tetraoxide	237-222-4	13701-59-2	17-Jan-2023	Toxic for reproduction (Article 57c)	D(2022)9120-DC	Details
Lead sulfochromate yellow (C.I. Pigment Yellow 34) -	215-693-7	1344-37-2	13-Jan-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/68/2009	Details
Lead diazide, Lead azide	236-542-1	13424-46-9	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
Chromium trioxide	215-607-8	1333-82-0	15-Dec-2010	Carcinogenic (Article 57a) Mutagenic (Article 57b)	ED/95/2010	Details
Disodium tetraborate, anhydrous	215-540-4	12179-04-3, 1303-96-4, 1330-43-4	18-Jun-2010	Toxic for reproduction (Article 57c)	ED/30/2010	Details
Diarsenic trioxide	215-481-4	1327-53-3	28-Oct-2008	Carcinogenic (Article 57a)	ED/67/2008	Details
Trilead bis(carbonate) dihydroxide	215-290-6	1319-46-6	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead monoxide (lead oxide)	215-267-0	1317-36-8	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Orange lead (lead tetroxide)	215-235-6	1314-41-6	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Dipentyl phthalate (DPP)	205-017-9	131-18-0	20-Jun-2013	Toxic for reproduction (Article 57c)	ED/69/2013	Details
Cadmium sulphide	215-147-8	1306-23-6	16-Dec-2013	Carcinogenic (Article 57a) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/121/2013	Details
Cadmium oxide	215-146-2	1306-19-0	20-Jun-2013	Carcinogenic (Article 57a) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/69/2013	Details
Diboron trioxide	215-125-8	1303-86-2	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
Diarsenic pentaoxide	215-116-9	1303-28-2	28-Oct-2008	Carcinogenic (Article 57a)	ED/67/2008	Details
Pyrene	204-927-3	129-00-0	15-Jan-2019	PBT (Article 57d) vPvB (Article 57e)	ED/88/2018	Details
N,N-dimethylacetamide	204-826-4	127-19-5	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
Lead chromate molybdate sulphate red (C.I. Pigment Red 104) -	235-759-9	12656-85-8	13-Jan-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/68/2009	Details
Lead titanium zirconium oxide	235-727-4	12626-81-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Dioxobis(stearato)trilead	235-702-8	12578-12-0	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
1,4-dioxane	204-661-8	123-91-1	08-Jul-2021	Carcinogenic (Article 57a) Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2021)4569-DC	Details
Diazene-1,2-dicarboxamide (C,C'-azodi(formamide)) (ADCA)	204-650-8	123-77-3	19-Dec-2012	Respiratory sensitising properties (Article 57(f) - human health)	ED/169/2012	Details
Tetraboron disodium heptaoxide, hydrate	235-541-3	12267-73-1	18-Jun-2010	Toxic for reproduction (Article 57c)	ED/30/2010	Details
Tetralead trioxide sulphate	235-380-9	12202-17-4	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Trilead dioxide phosphonate	235-252-2	12141-20-7	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
2,4-dinitrotoluene	204-450-0	121-14-2	13-Jan-2010	Carcinogenic (Article 57a)	ED/68/2009	Details
Pentalead tetraoxide sulphate	235-067-7	12065-90-6	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead titanium trioxide	235-038-9	12060-00-3	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Lead oxide sulfate	234-853-7	12036-76-9	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Disodium octaborate	234-541-0	12008-41-2	27-Jun-2018	Toxic for reproduction (Article 57c)	ED/61/2018	Details
6-methoxy-m-toluidine (p-cresidine)	204-419-1	120-71-8	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
Anthracene	204-371-1	120-12-7	28-Oct-2008	PBT (Article 57d)	ED/67/2008	Details
2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone CG 25-369; IRGACURE 369; TK 11-319	404-360-3	119313-12-1	16-Jan-2020	Toxic for reproduction (Article 57c)	ECHA_01_2020.pdf	Details
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol	204-327-1	119-47-1	17-Jan-2022	Toxic for reproduction (Article 57c)	D(2021)10043-DC	Details
Bis(2-methoxyethyl) phthalate	204-212-6	117-82-8	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
Bis (2-ethylhexyl)phthalate (DEHP)	204-211-0	117-81-7	28-Oct-2008	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - environment) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/108/2014 ED/30/2017 ED/67/2008	Details
Bis(pentabromophenyl) ether (decabromodiphenyl ether) (DecaBDE)	214-604-9	1163-19-5	19-Dec-2012	PBT (Article 57d) vPvB (Article 57e)	ED/169/2012	Details
Tris(2-chloroethyl) phosphate	204-118-5	115-96-8	13-Jan-2010	Toxic for reproduction (Article 57c)	ED/68/2009	Details
1,3-propanesultone	214-317-9	1120-71-4	17-Dec-2015	Carcinogenic (Article 57a)	ED/79/2015	Details
1,2-bis(2-methoxyethoxy)ethane (TEGDME; triglyme)	203-977-3	112-49-2	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
Silicic acid, lead salt	234-363-3	11120-22-2	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Potassium hydroxyoctaoxodizincatedichromate	234-329-8	11103-86-9	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
Bis(2-methoxyethyl) ether	203-924-4	111-96-6	19-Dec-2011	Toxic for reproduction (Article 57c)	ED/77/2011	Details
glutaral	203-856-5	111-30-8	08-Jul-2021	Respiratory sensitising properties (Article 57(f) - human health)	D(2021)4569-DC	Details
2-ethoxyethyl acetate	203-839-2	111-15-9	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
2-ethoxyethanol	203-804-1	110-80-5	15-Dec-2010	Toxic for reproduction (Article 57c)	ED/95/2010	Details
1, 2-dimethoxyethane; ethylene glycol dimethyl ether (EGDME)	203-794-9	110-71-4	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
2-methoxyethyl acetate	203-772-9	110-49-6	16-Jul-2019	Toxic for reproduction (Article 57c)	ED/71/2019	Details
Furan	203-727-3	110-00-9	19-Dec-2012	Carcinogenic (Article 57a)	ED/169/2012	Details
2-methoxyethanol	203-713-7	109-86-4	15-Dec-2010	Toxic for reproduction (Article 57c)	ED/95/2010	Details
Melamine	203-615-4	108-78-1	17-Jan-2023	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2022)9120-DC	Details
1-vinylimidazole	214-012-0	1072-63-5	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
Ethylenediamine EDA	203-468-6	107-15-3	27-Jun-2018	Respiratory sensitising properties (Article 57(f) - human health)	ED/61/2018	Details
1,2-dichloroethane	203-458-1	107-06-2	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details
tris(2-methoxyethoxy)vinylsilane	213-934-0	1067-53-4	17-Jan-2022	Toxic for reproduction (Article 57c)	D(2021)10043-DC	Details
1-bromopropane (n-propyl bromide)	203-445-0	106-94-5	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
Cadmium nitrate	233-710-6	10325-94-7	15-Jan-2018	Carcinogenic (Article 57a) Mutagenic (Article 57b) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/01/2018	Details
Cobalt(II) dinitrate	233-402-1	10141-05-6	15-Dec-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/95/2010	Details
Cobalt(II) sulphate	233-334-2	10124-43-3	15-Dec-2010	Carcinogenic (Article 57a) Toxic for reproduction (Article 57c)	ED/95/2010	Details
Cadmium chloride	233-296-7	10108-64-2	16-Jun-2014	Carcinogenic (Article 57a) Mutagenic (Article 57b) Toxic for reproduction (Article 57c) Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	ED/49/2014	Details
4,4'- Diaminodiphenylmethane (MDA)	202-974-4	101-77-9	28-Oct-2008	Carcinogenic (Article 57a)	ED/67/2008	Details
N,N,N',N'-tetramethyl-4,4'-methylenedianiline (Michler’s base)	202-959-2	101-61-1	18-Jun-2012	Carcinogenic (Article 57a)	ED/87/2012	Details
2,2'-dichloro-4,4'-methylenedianiline	202-918-9	101-14-4	19-Dec-2011	Carcinogenic (Article 57a)	ED/77/2011	Details

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Candidate List of substances of very high concern for Authorisation

Candidate List of substances of very high concern for Authorisation

(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

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