Candidate List of substances of very high concern for Authorisation

Candidate List of substances of very high concern for Authorisation

(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

Notes:

  • Authentic version: Only the Candidate List published on this website is deemed authentic. Companies may have immediate legal obligations following the inclusion of a substance in the Candidate List on this website including in particular Articles 7, 31 and 33 of the REACH Regulation.
  • Numerical identifiers: Each candidate list entry covers both anhydrous and hydrated forms of a substance. The CAS number shown in an entry is typically for the anhydrous form. Hydrated forms of the substance identified by other CAS numbers are still within the scope of the entry.
  • Other numerical identifiers: For those entries with "-" in the EC number and CAS number columns, a non-exhaustive inventory of EC and/or CAS Registry numbers describing substances or groups of substances considered to fall within the scope of the Candidate List entry is included, where practicably possible. This information can be accessed through the "Details" button of the selected entry. 
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Decision IUCLID dataset  
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17-Jan-2022
Endocrine disrupting properties (Article 57(f) - human health)
Details
with ≥ 0.3% of dihexyl phthalate (EC No. 201-559-5)
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1,2-Benzenedicarboxylic acid, di-C6-10-alkyl esters EC No.: 271-094-0 | CAS No.: 68515-51-5
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15-Jun-2015
Toxic for reproduction (Article 57c)


Details
covering any of its individual anti- and syn-isomers or any combination thereof
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15-Jan-2018
vPvB (Article 57e)
Details
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2,2-bis(bromomethyl)propane-1,3-diol (BMP) EC No.: 221-967-7 | CAS No.: 3296-90-0
2,2-dimethylpropan-1-ol, tribromo derivative (TBNPA) EC No.: 253-057-0 | CAS No.: 36483-57-5
3-bromo-2,2-bis(bromomethyl)-1-propanol (TBNPA) EC No.: - | CAS No.: 1522-92-5
2,3-dibromo-1-propanol (2,3-DBPA) EC No.: 202-480-9 | CAS No.: 96-13-9
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08-Jul-2021
Carcinogenic (Article 57a)
Details
covering any of their individual isomers and combinations thereof
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16-Jul-2019
Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
Details
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2-(4-tert-butylbenzyl)propionaldehyde EC No.: 201-289-8 | CAS No.: 80-54-6
(2S)-3-(4-tert-butylphenyl)-2-methylpropanal EC No.: - | CAS No.: 75166-30-2
(2R)-3-(4-tert-butylphenyl)-2-methylpropanal EC No.: - | CAS No.: 75166-31-3
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08-Jul-2021
Toxic for reproduction (Article 57c)
Details
show/hide
4,4'-oxydianiline EC No.: 202-977-0 | CAS No.: 101-80-4
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19-Dec-2012
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Details
covering well-defined substances and UVCB substances, polymers and homologues
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19-Dec-2012
Endocrine disrupting properties (Article 57(f) - environment)
Details
substances with a linear and/or branched alkyl chain with a carbon number of 7 covalently bound predominantly in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof
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Phenol, heptyl derivs. EC No.: 276-743-1 | CAS No.: 72624-02-3
4-heptylphenol EC No.: 217-862-0 | CAS No.: 1987-50-4
4-(2,3,3-trimethylbutan-2-yl)phenol EC No.: - | CAS No.: 72861-06-4
4-(2,4-dimethylpentan-2-yl)phenol EC No.: - | CAS No.: 33104-11-9
4-(3-ethylpentan-3-yl)phenol EC No.: - | CAS No.: 37872-24-5
4-(2-methylhexan-2-yl)phenol EC No.: - | CAS No.: 30784-31-7
4-(3,3-dimethylpentan-2-yl)phenol EC No.: - | CAS No.: 911371-06-7
4-(3-methylhexan-2-yl)phenol EC No.: - | CAS No.: 854904-93-1
4-(4,4-dimethylpentan-2-yl)phenol EC No.: - | CAS No.: 911371-07-8
4-(4-methylhexan-2-yl)phenol EC No.: - | CAS No.: 71945-81-8
4-(3-methylhexan-3-yl)phenol EC No.: - | CAS No.: 30784-32-8
4-(2,2-dimethylpentan-3-yl)phenol EC No.: - | CAS No.: 861010-65-3
4-(5-methylhexan-3-yl)phenol EC No.: - | CAS No.: 854904-92-0
4-(heptan-3-yl)phenol EC No.: - | CAS No.: 6465-74-3
4-(heptan-2-yl)phenol EC No.: - | CAS No.: 6863-24-7
4-(heptan-4-yl)phenol EC No.: - | CAS No.: 6465-71-0
4-(3-ethylpentyl)phenol EC No.: - | CAS No.: 911370-98-4
4-(3-methylhexyl)phenol EC No.: - | CAS No.: 102570-52-5
4-(4-methylhexyl)phenol EC No.: - | CAS No.: 1139800-98-8
4-(5-methylhexyl)phenol EC No.: - | CAS No.: 100532-36-3
4-(2,4-dimethylpentan-3-yl)phenol EC No.: - | CAS No.: 1824346-00-0
4-(2,3-dimethylpentan-2-yl)phenol EC No.: - | CAS No.: 861011-60-1
Phenol, 4-(1-ethyl-1,2-dimethylpropyl)- EC No.: - | CAS No.: 30784-27-1
Phenol, 4-tert-heptyl- EC No.: - | CAS No.: 288864-02-8
4-(5-methylhexan-2-yl)phenol EC No.: - | CAS No.: 857629-71-1
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12-Jan-2017
Endocrine disrupting properties (Article 57(f) - environment)
Details
substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof
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p-isononylphenol EC No.: 247-770-6 | CAS No.: 26543-97-5
4-(1-Ethyl-1,4-dimethylpentyl)phenol EC No.: - | CAS No.: 142731-63-3
4-(1-Ethyl-1,3-dimethylpentyl)phenol EC No.: - | CAS No.: 186825-36-5
p-(1-methyloctyl)phenol EC No.: 241-427-4 | CAS No.: 17404-66-9
p-(1,1-dimethylheptyl)phenol EC No.: 250-339-5 | CAS No.: 30784-30-6
4-(1-ethyl-1-methylhexyl)phenol EC No.: 257-907-1 | CAS No.: 52427-13-1
p-nonylphenol EC No.: 203-199-4 | CAS No.: 104-40-5
Phenol, 4-nonyl-, branched EC No.: 284-325-5 | CAS No.: 84852-15-3
4-(3-ethylheptan-2-yl)phenol EC No.: - | CAS No.: 186825-39-8
4-(1,1,5-Trimethylhexyl)phenol EC No.: - | CAS No.: 521947-27-3
Isononylphenol EC No.: 234-284-4 | CAS No.: 11066-49-2
Phenol, nonyl-, branched EC No.: 291-844-0 | CAS No.: 90481-04-2
Nonylphenol EC No.: 246-672-0 | CAS No.: 25154-52-3
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19-Dec-2012
Endocrine disrupting properties (Article 57(f) - environment)
Details
substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof
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20-(4-nonylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol EC No.: 248-743-1 | CAS No.: 27942-27-4
2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethanol EC No.: 230-770-5 | CAS No.: 7311-27-5
Nonylphenol, branched, ethoxylated
1 - 2.5 moles ethoxylated
EC No.: 500-209-1 | CAS No.: 68412-54-4
4-Nonylphenol, ethoxylated
1 - 2.5 moles ethoxylated
EC No.: 500-045-0 | CAS No.: 26027-38-3
Nonylphenol, ethoxylated EC No.: 500-024-6 | CAS No.: 9016-45-9
Nonylphenol, ethoxylated (10-EO) EC No.: - | CAS No.: 9016-45-9
Nonylphenol, ethoxylated (8-EO) EC No.: - | CAS No.: 9016-45-9
Nonylphenol, ethoxylated (6,5-EO) EC No.: - | CAS No.: 9016-45-9
2-[2-(4-nonylphenoxy)ethoxy]ethanol EC No.: 243-816-4 | CAS No.: 20427-84-3
Nonylphenol, ethoxylated (15-EO) EC No.: - | CAS No.: 9016-45-9
14-(nonylphenoxy)-3,6,9,12-tetraoxatetradecan-1-ol EC No.: 247-555-7 | CAS No.: 26264-02-8
26-(nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol EC No.: 247-816-5 | CAS No.: 26571-11-9
2-[2-(nonylphenoxy)ethoxy]ethanol EC No.: 248-291-5 | CAS No.: 27176-93-8
20-(nonylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol EC No.: 248-292-0 | CAS No.: 27177-03-3
23-(nonylphenoxy)-3,6,9,12,15,18,21-heptaoxatricosan-1-ol EC No.: 248-293-6 | CAS No.: 27177-05-5
29-(nonylphenoxy)-3,6,9,12,15,18,21,24,27-nonaoxanonacosanol EC No.: 248-294-1 | CAS No.: 27177-08-8
2-(nonylphenoxy)ethanol EC No.: 248-762-5 | CAS No.: 27986-36-3
26-(nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol; EC No.: 255-695-5 | CAS No.: 42173-90-0
2-(isononylphenoxy)ethanol EC No.: 284-987-5 | CAS No.: 85005-55-6
20-(isononylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol EC No.: 265-785-6 | CAS No.: 65455-69-8
4-Nonylphenol, branched, ethoxylated
1 - 2.5 moles ethoxylated
EC No.: 500-315-8 | CAS No.: 127087-87-0
4-Nonylphenol, branched, ethoxylated EC No.: - | CAS No.: 127087-87-0
Nonylphenol, ethoxylated (EO = 10) EC No.: - | CAS No.: -
Nonylphenol, ethoxylated (EO = 4) EC No.: - | CAS No.: -
Nonylphenol, ethoxylated (polymer) EC No.: - | CAS No.: -
2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethanol EC No.: - | CAS No.: 1119449-37-4
Nonylphenolpolyglycolether EC No.: - | CAS No.: -
Isononylphenol, ethoxylated EC No.: - | CAS No.: 37205-87-1
2-(4-nonylphenoxy)ethanol EC No.: - | CAS No.: 104-35-8
4-t-Nonylphenol-diethoxylate EC No.: - | CAS No.: 156609-10-8
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20-Jun-2013
Endocrine disrupting properties (Article 57(f) - environment)
Details
covering any of the individual stereoisomers of [1] and [2] or any combination thereof
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-
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15-Jun-2015
vPvB (Article 57e)
Details
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Chromic acid EC No.: 231-801-5 | CAS No.: 7738-94-5
Dichromic acid EC No.: 236-881-5 | CAS No.: 13530-68-2
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15-Dec-2010
Carcinogenic (Article 57a)


Details
are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium and silicon are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm) c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight
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Refractories, fibers, aluminosilicate EC No.: - | CAS No.: 142844-00-6
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19-Dec-2011
Carcinogenic (Article 57a)
Details
show/hide
Bis(2-ethylhexyl) tetrabromophthalate EC No.: 247-426-5 | CAS No.: 26040-51-7
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17-Jan-2023
vPvB (Article 57e)
Details
EC No. 233-139-2 and EC No. 234-343-4
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Boric acid EC No.: 233-139-2 | CAS No.: 10043-35-3
Boric acid, crude natural EC No.: 234-343-4 | CAS No.: 11113-50-1
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18-Jun-2010
Toxic for reproduction (Article 57c)


Details
all possible combinations of the cis- and trans-isomers
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trans-cyclohexane-1,2-dicarboxylic anhydride EC No.: 238-009-9 | CAS No.: 14166-21-3
Cyclohexane-1,2-dicarboxylic anhydride EC No.: 201-604-9 | CAS No.: 85-42-7
cis-cyclohexane-1,2-dicarboxylic anhydride EC No.: 236-086-3 | CAS No.: 13149-00-3
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19-Dec-2012
Respiratory sensitising properties (Article 57(f) - human health)



Details
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Dioctyltin dilaurate EC No.: 222-883-3 | CAS No.: 3648-18-8
Stannane, dioctyl-, bis(coco acyloxy) derivs. EC No.: 293-901-5 | CAS No.: 91648-39-4
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19-Jan-2021
Toxic for reproduction (Article 57c)
Details
and all major diastereoisomers identified
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1,2,5,6,9,10-hexabromocyclododecane EC No.: 221-695-9 | CAS No.: 3194-55-6
gamma-hexabromocyclododecane EC No.: - | CAS No.: 134237-52-8
Hexabromocyclododecane EC No.: 247-148-4 | CAS No.: 25637-99-4
alpha-hexabromocyclododecane EC No.: - | CAS No.: 134237-50-6
beta-hexabromocyclododecane EC No.: - | CAS No.: 134237-51-7
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28-Oct-2008
PBT (Article 57d)





Details
including cis- and trans- stereo isomeric forms and all possible combinations of the isomers
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Hexahydro-1-methylphthalic anhydride EC No.: 256-356-4 | CAS No.: 48122-14-1
Hexahydro-3-methylphthalic anhydride EC No.: 260-566-1 | CAS No.: 57110-29-9
Hexahydromethylphthalic anhydride EC No.: 247-094-1 | CAS No.: 25550-51-0
Hexahydro-4-methylphthalic anhydride EC No.: 243-072-0 | CAS No.: 19438-60-9
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19-Dec-2012
Respiratory sensitising properties (Article 57(f) - human health)




Details
UVCB substances consisting of more than or equal to 80% linear chloroalkanes with carbon chain lengths within the range from C14 to C17
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di-, tri- and tetrachlorotetradecane EC No.: - | CAS No.: -
Alkanes, C14-17, chloro EC No.: 287-477-0 | CAS No.: 85535-85-9
Tetradecane, chloro derivs. EC No.: - | CAS No.: 198840-65-2
Alkanes, C14-16, chloro EC No.: - | CAS No.: 1372804-76-6
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08-Jul-2021
PBT (Article 57d)
vPvB (Article 57e)
Details
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776297-69-9
19-Dec-2012
Toxic for reproduction (Article 57c)
Details
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Nonadecafluorodecanoic acid EC No.: 206-400-3 | CAS No.: 335-76-2
sodium nonadecafluorodecanoate EC No.: - | CAS No.: 3830-45-3
Ammonium nonadecafluorodecanoate EC No.: 221-470-5 | CAS No.: 3108-42-7
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12-Jan-2017
Toxic for reproduction (Article 57c)
PBT (Article 57d)
Details
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Boric acid, sodium salt EC No.: 215-604-1 | CAS No.: 1333-73-9
Orthoboric acid, sodium salt EC No.: 237-560-2 | CAS No.: 13840-56-7
boric acid (H3BO3), sodium salt, hydrate EC No.: - | CAS No.: 25747-83-5
boric acid (H3BO3), sodium salt (1:1) EC No.: - | CAS No.: 14890-53-0
Boric acid (H3BO3), disodium salt EC No.: - | CAS No.: 22454-04-2
Trisodium orthoborate EC No.: 238-253-6 | CAS No.: 14312-40-4
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08-Jul-2021
Toxic for reproduction (Article 57c)
Details
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magnesium perfluorobutanesulfonate EC No.: - | CAS No.: 507453-86-3
lithium perfluorobutanesulfonate EC No.: - | CAS No.: 131651-65-5
morpholinium perfluorobutanesulfonate EC No.: - | CAS No.: 503155-89-3
1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonic acid EC No.: 206-793-1 | CAS No.: 375-73-5
Ammonium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate EC No.: 269-513-7 | CAS No.: 68259-10-9
tetrabutyl-phosphonium nonafluoro-butane-1-sulfonate EC No.: 444-440-5 | CAS No.: 220689-12-3
dimethyl(phenyl)sulfanium perfluorobutanesulfonate EC No.: 452-310-4 | CAS No.: 220133-51-7
Triphenylsulfanium perfluorobutane sulfonate EC No.: 478-340-8 | CAS No.: 144317-44-2
Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate EC No.: 249-616-3 | CAS No.: 29420-49-3
bis(4-t-butylphenyl)iodonium perfluorobutanesulfonate EC No.: 432-660-4 | CAS No.: 194999-85-4
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16-Jan-2020
Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
Details
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Perfluoroheptanoic acid EC No.: 206-798-9 | CAS No.: 375-85-9
Sodium perfluoroheptanoate EC No.: 243-518-4 | CAS No.: 20109-59-5
Ammonium perfluoroheptanoate EC No.: 228-098-2 | CAS No.: 6130-43-4
potassium perfluoroheptanoate EC No.: - | CAS No.: 21049-36-5
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17-Jan-2023
Toxic for reproduction (Article 57c)
PBT (Article 57d)
vPvB (Article 57e)
Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
Details
PFHxS
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ammonium perfluorohexane-1-sulphonate EC No.: 269-511-6 | CAS No.: 68259-08-5
perfluorohexane-1-sulphonic acid EC No.: 206-587-1 | CAS No.: 355-46-4
potassium perfluorohexane-1-sulphonate EC No.: 223-393-2 | CAS No.: 3871-99-6
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07-Jul-2017
vPvB (Article 57e)
Details
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Ammonium salts of perfluorononan-1-oic-acid EC No.: - | CAS No.: 4149-60-4
Perfluorononan-1-oic-acid EC No.: 206-801-3 | CAS No.: 375-95-1
Sodium salts of perfluorononan-1-oic-acid EC No.: - | CAS No.: 21049-39-8
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17-Dec-2015
Toxic for reproduction (Article 57c)
PBT (Article 57d)
Details
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4-isododecylphenol EC No.: - | CAS No.: 27459-10-5
Phenol, tetrapropylene- EC No.: - | CAS No.: 57427-55-1
Phenol, 4-dodecyl, branched EC No.: - | CAS No.: 210555-94-5
Phenol, (tetrapropenyl) derivatives EC No.: - | CAS No.: 74499-35-7
Phenol, 4-isododecyl- EC No.: - | CAS No.: 27147-75-7
Phenol, dodecyl-, branched EC No.: 310-154-3 | CAS No.: 121158-58-5
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08-Jul-2021
Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - environment)
Endocrine disrupting properties (Article 57(f) - human health)
Details
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17-Dec-2014
Toxic for reproduction (Article 57c)
Details
with ≥0.1% w/w 4-heptylphenol, branched and linear (4-HPbl)
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15-Jan-2018
Endocrine disrupting properties (Article 57(f) - environment)
Details
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Perboric acid, sodium salt, tetrahydrate () EC No.: - | CAS No.: 37244-98-7
Perboric acid (HBO(O2)), sodium salt, tetrahydrate EC No.: - | CAS No.: 10486-00-7
Sodium perborate monohydrate EC No.: - | CAS No.: 10332-33-9
Sodium perborate EC No.: 239-172-9 | CAS No.: 15120-21-5
Perboric acid, sodium salt EC No.: 234-390-0 | CAS No.: 11138-47-9
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16-Jun-2014
Toxic for reproduction (Article 57c)
Details
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tris(nonylphenyl) phosphite EC No.: 247-759-6 | CAS No.: 26523-78-4
Phenol, 4-nonyl-, phosphite (3:1) EC No.: - | CAS No.: 3050-88-2
Phenol, p-isononyl-, phosphite (3:1) EC No.: - | CAS No.: 31631-13-7
Phenol, p-sec-nonyl-, phosphite EC No.: - | CAS No.: 106599-06-8
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16-Jul-2019
Endocrine disrupting properties (Article 57(f) - environment)
Details
are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium, silicon and zirconium are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm). c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight
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Refractories, fibers, aluminosilicate EC No.: - | CAS No.: 142844-00-6
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19-Dec-2011
Carcinogenic (Article 57a)
Details
200-028-5
50-32-8
20-Jun-2016
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Toxic for reproduction (Article 57c)
PBT (Article 57d)
vPvB (Article 57e)
Details
200-268-0
56-35-9
28-Oct-2008
PBT (Article 57d)
Details
200-280-6
56-55-3
15-Jan-2018
Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
Details
200-453-6
60-09-3
19-Dec-2012
Carcinogenic (Article 57a)
Details
200-589-6
64-67-5
19-Dec-2012
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Details
200-679-5
68-12-2
19-Dec-2012
Toxic for reproduction (Article 57c)
Details
200-755-8
71-48-7
15-Dec-2010
Carcinogenic (Article 57a)
Toxic for reproduction (Article 57c)
Details
200-842-0
75-12-7
18-Jun-2012
Toxic for reproduction (Article 57c)
Details
200-879-2
75-56-9
19-Dec-2012
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Details
201-004-7
77-09-8
19-Dec-2011
Carcinogenic (Article 57a)
Details
201-025-1
77-40-7
08-Jul-2021
Endocrine disrupting properties (Article 57(f) - environment)
Endocrine disrupting properties (Article 57(f) - human health)
Details
201-058-1
77-78-1
19-Dec-2012
Carcinogenic (Article 57a)
Details
201-075-4
78-00-2
19-Dec-2012
Toxic for reproduction (Article 57c)
Details
201-167-4
79-01-6
18-Jun-2010
Carcinogenic (Article 57a)
Details
201-173-7
79-06-1
30-Mar-2010
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Details
201-182-6
79-16-3
19-Dec-2012
Toxic for reproduction (Article 57c)
Details

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