reaction mass of mono to tetra(lithium and/or sodium)3-amino-10-[4-(4-amino-3-sulfonatoanilino)-6-[methyl-(2-sulfonatoethyl)amino]-1,3,5-triazin-2-ylamino]-6-13-dichlorobenzo[1,2-B:4,5-B']di[1,4]benzoxazine-4,11-disulfonate; mono to tetra(lithium and/or sodium)3-amino-10-[4,6-bis(4-amino-3-sulfonatoanilino)-1,3,5-triazin-2-ylamino]-6-13-dichlorobenzo[1,2-B:4,5-B']di[1,4]benzoxazine-4,11-disulfonate; mono to penta(lithium and/or sodium)10,10´-diamino-6,6',13,13´-tetrachloro-3,3'-[6-[methyl-(2-sulfonatoethyl)amino]-1,3,5-triazin-2,4-diyldiimino]bis[benzo[1,2-B:4,5-B']di[1,4]benzoxazine-4,11-disulfonate; mono to hepta(lithium and/or sodium)10-amino-6,6',13,13'-tetrachloro-10´[4-(4-amino-3-sulfonatoanilino)-[6-methyl-(2-sulfonatoethyl)amino]-1,3,5-triazin-2,4-diimino]bis[benzo[1,2-B:4,5-B']di[1,4]benzoxazine-4,11-disulfonate; mono to hepta(lithium and/or sodium)10,10'-diamino-6,6',3,3'[(2-sulfonato)-1,4-phenylenediiminobis[6-methyl-(2-sulfonatoethyl)amino]-1,3,5-triazin-2,4-diyldiimino]bis[benzo[1,2-B:4,5-B']di[1,4]benzoxazine-4,11-disulfonate

Study results

If more than one result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Solubility provides substance information on the substance’s solubility in organic solvents/fat in grams per litre at a temperature measured in °C. Registrants can provide data for one or more of the following picklist options:

• Standard fat
• Acetone
• Acetonitrile
• Benzene
• N-butanol
• Cyclohexane
• Diethyl ether
• Diethyl ketone
• Dimethylformamide
• DMSO, ethanol
• Ethyl acetate
• Isopropanol
• Methanol
• N-octanol
• Toluene

Note: Registrants can also select ‘other’ as the solvent. If so, the data provided is not processed for the Brief Profile.

Also, if the registrant selects the ‘mg/100 g solvent’; ‘g/kg solvent’; ‘ppb’; ‘vol%’ and ‘other’ as a unit of measure, the data provided will not be processed for the Brief Profile.

Summary

Solubility in mg/100g standard fat at 20°C provides substance information on the substance solubility in standard fat in milligram per 100 gram at a temperature of 20°C.

Solubility in organic solvents at 20°C provides substance information on the substance solubility in organic solvents in gram per litre at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the oxidation reduction potential values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Oxidation reduction potential in mV provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature measured in °C.

Summary

Oxidation reduction potential in mV at 20°C provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the pH values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

pH provides substance information on the substance’s acidity level measured in pH at a temperature measured in °C and a concentration measured in (milli)grams per litre.

Note: Results without a concentration value are not processed for the Brief Profile.

Summary

For this endpoint registrants do not provide summary data.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the dissociating values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one picklist value is available per endpoint, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Dissociating Properties provides substance information by picklist values:

• Yes
• No
• Ambiguous
• Not determined

Dissociation Constant provides numerical substance information on the substance’s dissociation constant values at a temperature measured in °C.

Summary

pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the viscosity values from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min–max) and range of experimental conditions will be presented (RANGE method).

Registrants can report substance information on viscosity as:

• Dynamic viscosity (in mPa s)
• Kinematic viscosity (in mm²)/s)
• Flow time (in s) – ASTM Cup 1
• Flow time (in s) – ASTM Cup 2
• Flow time (in s) – ASTM Cup 3
• Flow time (in s) – ASTM Cup 4
• Flow time (in s) – 3 mm ISO cup
• Flow time (in s) – 4 mm ISO cup
• Flow time (in s) – 5 mm ISO cup
• Flow time (in s) – 6 mm ISO cup
• Flow time (in s) – other:

Summary

Static viscosity at 20°C provides substance information on the substance’s (static) viscosity per square millimetre per second at a temperature of 20°C.

Dynamic viscosity at 20°C provides substance information on the substance’s (dynamic) viscosity per millipascal second at a temperature of 20°C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to phototransformation in air from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max, RANGE method) will be displayed.

Dissipation half-life provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year.

Degradation rate constant (OH Radicals) provides substance information on the substance’s degradation rate constant with OH Radicals as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1.

Degradation rate constant (Ozone) provides substance information on the substance’s degradation rate constant with Ozone as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1.

Note: Registrants can also select ‘other’ as a reaction type for the degradation rate constant of the substance. If so, the data provided is not processed in the Brief Profile.

Summary

Half-life in air provides substance information on the substance’s dissipation half-life in air in seconds/minutes/hours/days/weeks/months/years.

Degradation rate constant with OH radicals provides substance information on the substance’s degradation rate constant with OH Radicals as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to phototransformation in water from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Dissipation Half-life of parent compound provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year.

Summary

Phototransformation in water provides information on the substance’s phototransformation in water in seconds/minutes/hours/days/weeks/months/years.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to phototransformation in soil from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Dissipation Half-life of parent compound provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year.

Summary

Phototransformation in soil provides substance information on the substance’s phototransformation in soil in seconds/minutes/hours/days/weeks/months/years.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to the simulation tests for biodegradation in water and sediments from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Half-life in water provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.

Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles.

Half-life in sediment provides substance information on the substance’s half-life in sediment in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.
Note: Results without a measurement condition (temperature) are not processed for the Brief Profile.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to biodegradation in soil from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Half-life in soil provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.

Note: Results without a measurement condition (temperature) are not processed for the Brief Profile.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to aquatic/sediment bioaccumulation in all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Bioaccumulation factor (aquatic species) provides substance information on the substance’s bioaccumulative properties not taking account the dimensions.

Bioaccumulation Factor (aquatic species) L/kg ww provides substance information on the substance’s bioaccumulative properties for aquatic species measured in litre per kilogram  (wet weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to terrestrial bioaccumulation in all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary data

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Bioaccumulation factor (terrestrial species) provides substance information on the substance’s terrestrial bioaccumulative properties not taking account the dimensions.

Bioaccumulation Factor (terrestrial species) L/kg ww provides substance information on the substance’s terrestrial bioaccumulative properties measured in litre per kilogram (wet weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to adsorption/desorption from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon.

Log Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon.

Kd provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon.

Log Kd provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon.

Note: If the measurement condition (percentage of organic carbon) is not provided by the registrant for adsorption coefficient Kd, the data provided is not processed for the Brief Profile.

Summary

Koc at 20°C provides substance information on the substance’s Koc adsorption at a temperature 20 °C.

Log Koc at 20°C provides substance information on the substance’s log Koc adsorption at a temperature 20 °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to Henry’s law constant (H) from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Henry’s law constant can be presented as different types, depending on the units chosen:

H dimensionless provides substance information on the substance’s Henry’s Law Constant (dimensionless) at a temperature measured in °C and a pressure measured in Pascal.

H dimensionless volumetric basis provides substance information on the substance’s Henry’s Law Constant in dimensionless volumetric basis at a temperature measured in °C and a pressure measured in Pascal.

H atm provides substance information on the substance’s Henry’s Law Constant in atm at temperature measured in °C and a pressure measured in Pascal.

H atm m3/mol provides substance information on the substance’s Henry’s Law Constant in atm m3/mol at a temperature measured in °C and a pressure measured in Pascal.

H Pa m3/mol provides substance information on the substance’s Henry’s Law Constant in Pa m3/mol at a temperature measured in °C and the atmospheric pressure measured in Pascal.

Note: Registrants can also select ‘other’ as the type of Henry’s law constant. If so, the data provided is not processed for the Brief Profile.

Summary

Henry’s Law Constant provides substance information on the substance’s Henry’s Law Constant measured in in Pa.m3.mol-1 at a temperature measured in °C.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to distribution modelling from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of values (provided in %).

Percentage distribution in the Media displays the values attributed by the registrants to the following options:

• air
• water
• soil
• sediment
• suspended sediment
• biota
• aerosol

Summary

For this endpoint registrants do not provide summaries that are processable for the Brief Profile.Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

If more than one numerical result is available per endpoint, the range of results (min-max) will be presented (RANGE method).

Hazard to aquatic organisms provides information on the substance’s hazard assessment conclusion regarding aquatic organisms.

Manufacturers and importers can provide the following information in the registration dossier:

Freshwater/marine water/intermittent:

• PNEC aqua, displayed in milligram per litre.
• No data: aquatic toxicity unlikely
• No data available: testing technically not feasible
• No hazard identified

Sewage treatment plant (STP)

• PNEC STP, data displayed in milligram per litre.
• No data: aquatic toxicity unlikely
• No data available: testing technically not feasible
• No emission the STP expected
• No hazard identified

Sediment freshwater/marine water

• PNEC sediment, data displayed in milligram per kilo sediment (dry weight).
• No or insufficient data available at present
• No exposure of sediment expected
• No data available: testing technically not feasible
• No hazard identified

Hazard for Air provides information on the substance’s hazard assessment conclusion related to air.

Data is generally standardised and displayed in milligram per litre/cubic metre.

Manufacturers and importers can provide the following information in the registration dossier:

• PNEC air
• Hazard related to composition of atmosphere identified
• No hazard identified 

Hazard for terrestrial organisms provides information on the substance’s hazard assessment conclusion related to terrestrial organisms/soil.

Data is generally standardised and displayed in milligram per kilo soil (dry weight).

Manufacturers and importers can provide the following information in the registration dossier:

• PNEC soil
• No or insufficient data available at present
• No exposure of soil expected
• No data available: testing technically not feasible
• No hazard identified

Hazard for predators provides information on the substance’s hazard assessment conclusion related to predators/secondary poisoning.

Data is generally standardised and displayed in in milligram per kilo of food.

Manufacturers and importers can provide the following information in the registration dossier:

• PNEC oral
• No potential for bioaccumulation
• No potential to cause toxic effects if accumulated (in higher organisms) via the food chain
• No or insufficient data available at present
• No data available: testing technically not feasible

This section summarises the values related to long term toxicity to fish from all registered dossiers for the substance.

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. IC10
6. EC50
7. LC50
8. IC50
9. EL10
10. EL50
11. LL10
12. LL50
13. NOELR
14. LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.  

EC10 / LC10 or NOEC for marine fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to long term toxicity to aquatic invertebrates from all registered dossiers for the substance.  

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. IC10
6. EC50
7. LC50
8. IC50
9. EL10
10. EL50
11. LL10
12. LL50
13. NOELR
14. LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre. 

EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to aquatic plants (other than algae) from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally standardised and the displayed in milligram per litre or molar per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

1. EC50
2. IC50
3. NOEC
4. LOEC
5. EC10
6. IC10
7. EC20
8. EC5
9. EC0
10. EC100
11. IC100
12. EC90
13. EL0
14. EL5
15. EL10
16. EL20
17. EL50
18. EL90
19. EL100
20. NOELR
21. LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC/LC50 for freshwater plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the freshwater plants in the test, generally displayed in milligram per litre.

EC50/LC50 for marine water plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre.

EC10 / LC10 or NOEC for freshwater plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater plants or the no observed effect concentration for freshwater plants. Values are generally displayed in milligram per litre.

EC10 / LC10 or NOEC for marine water plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water plants or the no observed effect concentration for marine water plants. Values are generally displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to sediment toxicity from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram sediment (dry weight) or in milligram per litre.

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter).

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. LD10
6. EC50
7. LC50
8. LD50
9. EC0
10. LC0
11. LD0
12. EC100
13. LC100
14. LD100
15. LR10
16. LR50
17. LR0
18. LR100

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment, generally displayed in milligrams per kilogram sediment (dry weight).

EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram sediment (dry weight).

EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. Values are generally displayed in milligrams per kilogram (dry weight).  

EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. Values are generally displayed in milligrams per kilogram (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to endocrine disrupter testing in aquatic vertebrates from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per litre.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter).

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. IC10
6. EC50
7. LC50
8. IC50
9. EL10
10. EL50
11. LL10
12. LL50
13. NOELR
14. LOELR

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.  

EC10 / LC10 or NOEC for marine fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Values are displayed in milligram per litre.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to soil macroorganisms (except arthropods) from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight) or gram per hectare.

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. LD10
6. EC50
7. LC50
8. LD50
9. EC0
10. LC0
11. LD0
12. EC100
13. LC100
14. LD100
15. LR10
16. LR50
17. LR0
18. LR100

Prioritisation by units (dry weight):

1. Mg/cm2
2. g/ha

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment,  generally displayed in milligrams per kilogram (dry weight).

EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram (dry weight).

EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. Values are generally displayed in milligrams per kilogram (dry weight).  

EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. . Values are generally displayed in measured in (nano/ micro/milli)gram per kilogram (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to (terrestrial) arthropods from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed reported as provided by the registrant(s).

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by unit.

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. LD10
6. EC50
7. LC50
8. LD50
9. EC0
10. LC0
11. LD0
12. EC100
13. LC100
14. LD100
15. LR10
16. LR50
17. LR0
18. LR100

Prioritisation by unit:

1. soil dw (g/ha and mg/cm²)
2. soil ww; (g/ha and mg/cm²)
3. µg per animal
4. mL/ha; mg/kg bw
5. mg/kg diet
6. ppm
7. mg/kg dung dw

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the soil dwelling arthropods in the test, generally displayed in milligram per kilo soil (dry weight).

Long-term EC10 or LC10 or NOEC for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil dwelling arthropods in the test, or the no observed effect concentration for soil dwelling arthropods. Values are generally displayed in milligram per kilo soil (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to (terrestrial) plants from all registered dossiers for the substance. 

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed reported as provided by the registrant(s).
The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

1. NOEC
2. LOEC
3. EC10
4. LC10
5. EC50
6. LC50
7. EC0
8. EC25
9. EC100
10. LC0
11. LC25
12. LC100
13. ER0
14. ER10
15. ER25
16. ER50
17. ER100

Prioritisation by units:

1. soil dw (g/ha, kg/ha and lbs/acre).
2. soil ww (g/ha, kg/ha and lbs/acre).

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight).

Long-term EC10 or LC10 or NOEC for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the terrestrial plants in the test, or the no observed effect concentration for terrestrial plants. Values are generally displayed in milligram per kilo soil (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to soil microorganisms from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed reported as provided by the registrant(s).

The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

1. NOEC
2. EC10
3. EC25
4. EC50
5. EC100
6. EC0
7. ER0
8. ER10
9. ER25
10. ER50
11. ER100

Prioritisation by units:

1. Soil dw (g/ha, kg/ha and lbs/acre).
2. Soil ww (g/ha, kg/ha and lbs/acre).

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).

Short-term EC50 or LC50 for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of soil microorganisms in the test, generally displayed in milligram per kilo soil (dry weight).

Long-term EC10 or LC10 or NOEC for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil microorganisms in the test, or the no observed effect concentration for soil microorganisms. Values are generally displayed in milligram per kilo soil (dry weight).

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to birds from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram, per bodyweight per day. Otherwise data is displayed reported as provided by the registrant(s).
The availability of additional data beyond the five results displayed is indicated by (…).

Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units .

Prioritisation by dose descriptor type:

1. NOEC
2. LOEC
3. LC50
4. LD50
5. LOEC
6. LOEL

Prioritisation by unit:

1. bw/day (mg/kg bw/day; mg/kg bw/day; mg/kg bw/day)
2. mg/kg bw
3. mg/kg diet
4. mg/L drinking water.

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for birds provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of birds in the test, generally displayed in milligram per kilo food.

Long-term EC10 or LC10 or NOEC for birds provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the birds in the test, or the no observed effect concentration for birds. Values are generally displayed in milligram per kilo food.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section summarises the values related to toxicity to mammals (other above-ground organisms) from all registered dossiers for the substance. 

More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header.

Study results

Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Otherwise data is displayed as provided by the registrant(s).

The availability of additional data beyond the five results displayed is indicated by (…).
Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Thirdly the display of data is prioritised by units.

Prioritisation by dose descriptor:

1. NOEC
2. EC50
3. LC50
4. LD50
5. EC100
6. LC100
7. LD100
8. EC0
9. LC0
10. LD0
11. LR50
12. LR0
13. LR100
14. ER50
15. ER0
16. ER100

Prioritisation by units

1. Soil dw (g/ha and mg/cm²)
2. Soil ww; (g/ha and mg/cm²)
3. µg per animal
4. mL/ha; mg/kg bw
5. mg/kg diet
6. ppm.
7. mg/kg dung dw

Note: Registrants can also select ‘other’ as the dose descriptor type or unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary

Short-term EC50 or LC50 for mammals provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of mammals in the test, generally displayed in milligram per kilo food.

Long-term EC10 or LC10 or NOEC for mammals provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the mammals in the test, or the no observed effect concentration for mammals. Values are generally displayed in milligram per kilo food.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section provides information on the derived no- or minimal effect level (DN(M)EL), the level of exposure above which a human should not be exposed to a substance.

When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

When more than one result is available per endpoint the ‘worst case’ or most conservative of all the data values provided are displayed, applying a precautionary principal. The aim is to display the lowest values reported as causing the most adverse effects, and hence the broadest possible safety margins for the substance.

Inhalation exposure provides information on the substance’s hazard assessment conclusions regarding inhalation exposure.

Registrant can provide information on the long and acute/short term exposure for both systemic and local effects of inhalation exposure of workers and/or general population by selecting one of the following hazard assessment conclusions:

1. DNEL (Derived No-Effect Level)
2. DMEL (Derived Minimum Effect Level) - not included for short–term effects
3. Other toxicological threshold
4. High hazard (no threshold derived)
5. Medium hazard (no threshold derived)
6. Low hazard (no threshold derived)
7. Insufficient data available (further information necessary)
8. Hazard unknown (no further information necessary)
9. No hazard identified
10. Hazard unknown but no further hazard information necessary as no exposure expected

Prioritisation of display occurs based on the order above. If a threshold is derived, the type of hazard assessment conclusion is displayed and the registered threshold is reported in (nano/micro/milli)gram per cubic metre. If more than one DNEL/DMEL is available the most conservative (i.e. the lowest numerical data) is displayed.

Information on the most sensitive study can be provided by the registrants as:

1. Acute toxicity
2. Repeated dose toxicity
3. Effect on fertility
4. Developmental toxicity/teratogenicity
5. Neurotoxicity
6. Immunotoxicity
7. Sensitisation (skin)
8. Sensitisation (respiratory tract)
9. Carcinogenicity
10. Skin irritation/corrosion
11. Irritation (respiratory tract)
12. Genetic toxicity

Dermal exposure provides information on the substance’s hazard assessment conclusions regarding dermal exposure (for workers).

See ‘Data for workers – Inhalation exposure’, with the following additional hazard assessment conclusion in the case of short term:

• ‘No DNEL required: short term exposure controlled by conditions for long-term’ is added

The registered threshold is generally displayed in milligrams per kilogram per bodyweight per day.

Data for workers – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for workers).

Registrant can provide information on eye exposure by selecting one of the following hazard assessment conclusions:

1. High hazard (no threshold derived)
2. Medium hazard (no threshold derived)
3. Low hazard (no threshold derived)
4. Hazard unknown (no further information necessary)
5. No hazard identified
6. Hazard unknown but no further hazard information necessary as no exposure expected

Data for general population – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for the general population).

Registrant can provide information on eye exposure as mentioned above for ‘Data for workers – eye exposure.’

This section displays the values related to carcinogenicity from all registered dossiers for the substance.

Study results

Study results are not processed for carcinogenicity in the context of Brief Profiles due to the use of complex field(s) to report the information, which cannot be easily summarised by an automatic algorithm.

Summary oral route

Processable data for summary is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed is the most conservative of the prioritised value(s). If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion.

Data is generally displayed in milligrams per kilogram bodyweight per day.

Prioritization by test species:

1. Rat
2. Mouse
3. Dog
4. Cat
5. Cattle
6. Gerbil
7. Guinea pig
8. Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian)
9. Hen
10. Miniature swine
11. Monkey
12. Pig
13. Primate
14. Rabbit
15. Sheep

Note: Registrants can also select ‘other’ as the test species. If so, the data provided is not processed for the Brief Profile.

Prioritisation by descriptor type:

1. NOAEL
2. LOAEL
3. T25
4. BMDL05
5. BMD05
6. BMDL10

Prioritisation by test type:

1. Chronic
2. Subchronic
3. Subacute

Prioritisation by endpoint conclusion:

1. Adverse effect observed
2. No adverse effect observed
3. No study available / no study available (further information necessary)

Summary dermal route

See ‘Summary oral Route’

Summary inhalation route

See ‘Summary oral Route’, except:

Measurement units: mg/m3

Prioritisation by dose descriptor type:

1. NOAEC
2. LOAEC
3. BMCL05
4. BMC05
5. BMCL10
6. T25

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section displays the values related to reproductive toxicity from all registered dossiers for the substance.

Study results

Study results are not processed for carcinogenicity in the context of Brief Profiles due to the use of complex field(s) to report the information, which cannot be easily summarised by an automatic algorithm.

Summary effect on fertility oral route

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed is the most conservative of the prioritised value(s). If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion.

Data is generally displayed in milligrams per kilogram bodyweight per day.
Prioritization by test species:

1. Rat
2. Mouse
3. Dog
4. Cat
5. Cattle
6. Gerbil
7. Guinea pig
8. Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian)
9. Hen
10. Miniature swine
11. Monkey
12. Pig
13. Primate
14. Rabbit
15. Sheep

Note: Registrants can also select ‘other’ as the test species. If so, the data provided is not processed for the Brief Profile.

Prioritisation by descriptor type:

1. NOAEL
2. LOAEL
3. T25
4. BMDL05
5. BMD05
6. BMDL10

Prioritisation by test type:

1. Chronic
2. Subchronic
3. Subacute

Prioritisation by endpoint conclusion:

1. Adverse effect observed
2. No adverse effect observed
3. No study available / no study available (further information necessary)

Summary effect on fertility dermal route

See ‘Summary effect on fertility oral route’

Summary effect on fertility inhalation route

See ‘Summary effect on fertility oral route’, except:

Dose descriptor prioritization:

1. NOAEC
2. LOAEC
3. BMCL01
4. BMC05
5. BMCL10

Measurement units: mg/m3

Summary developmental toxicity oral route

See ‘Summary effect on fertility oral route’

Summary developmental toxicity dermal route

See ‘Summary effect on fertility oral route’

Summary developmental toxicity inhalation route

See ‘Summary effect on fertility oral route’, except:

Dose descriptor prioritization:

1. NOAEC
2. LOAEC
3. BMCL01
4. BMC05
5. BMCL10

Measurement units: mg/m3

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section displays the values related to neurotoxicity from all registered dossiers for the substance.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary oral route

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed is the most conservative of the prioritised value(s). If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion.

Data is generally displayed in milligrams per kilogram bodyweight per day.

Prioritization by test species:

1. Rat
2. Mouse
3. Dog
4. Cat
5. Cattle
6. Gerbil
7. Guinea pig
8. Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian)
9. Hen
10. Miniature swine
11. Monkey
12. Pig
13. Primate
14. Rabbit
15. Sheep

Prioritisation by descriptor type:

1. NOAEL
2. LOAEL
3. T25
4. BMDL05
5. BMD05
6. BMDL10

Prioritisation by test type:

1. Chronic
2. Subchronic
3. Subacute

Prioritisation by endpoint conclusion:

1. Adverse effect observed
2. No adverse effect observed
3. No study available / no study available (further information necessary)

Summary dermal route

See ‘Summary oral route’

Summary inhalation route

See ‘Summary oral route’, except:

Dose descriptor prioritization:

1. NOAEC
2. LOAEC
3. BMCL01
4. BMC05
5. BMCL10

Measurement units: mg/m3

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section displays the values related to immunotoxicity from all registered dossiers for the substance.

Study results

For this endpoint registrants do not provide study results that are processable for the Brief Profile.

Summary oral route

Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed is the most conservative of the prioritised value(s). If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion.

Data generally displayed in milligrams per kilogram bodyweight per day.

Prioritization by test species:

1. Rat
2. Mouse
3. Dog
4. Cat
5. Cattle
6. Gerbil
7. Guinea pig
8. Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian)
9. Hen
10. Miniature swine
11. Monkey
12. Pig
13. Primate
14. Rabbit
15. Sheep

Prioritisation by descriptor type:

1. NOAEL
2. LOAEL
3. T25
4. BMDL05
5. BMD05
6. BMDL10

Prioritisation by test type:

1. Chronic
2. Subchronic
3. Subacute

Prioritisation by endpoint conclusion:

1. Adverse effect observed
2. No adverse effect observed
3. No study available / no study available (further information necessary)

Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. If so, the data provided is not processed for the Brief Profile.

Summary dermal route

See ‘Summary oral route’

Summary inhalation route

See ‘Summary oral route’, except:

Dose descriptor prioritization:

1. NOAEC
2. LOAEC
3. BMCL01
4. BMC05
5. BMCL10

Measurement units: mg/m3

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.

This section displays the values related to endocrine disrupter mammalian screening from all registered dossiers for the substance.

Study results

If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. The % is based on count of values provided.

Type of study provided

This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications.