Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: 2,5-bis-isocyanatomethyl-bicyclo[2.2.1]heptane
  • IUPAC name: (1R,2R,4R,5R)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; (1R,2S,4R,5S)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; (1S,2R,4S,5R)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; (1S,2S,4S,5S)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; bis((1r,2R,4s,6S)-2,6-bis(isocyanatomethyl)bicyclo[2.2.1]heptane); bis((1s,2R,4r,6S)-2,6-bis(isocyanatomethyl)bicyclo[2.2.1]heptane)
  • Other names
EC / List no.:
411-280-2
CAS no.:
74091-64-8
Index number:
615-029-00-X
Molecular formula:
C88H112N16O16
SMILES:
O=C=NC[C@H]1C[C@H]2C[C@@H]1C[C@@H]2CN=C=O.O=C=NC[C@H]1C[C@@H]2C[C@H]1C[C@@H]2CN=C=O.O=C=NC[C@@H]1C[C@H]2C[C@@H]1C[C@H]2CN=C=O.O=C=NC[C@@H]1C[C@@H]2C[C@H]1C[C@H]2CN=C=O.O=C=NC[C@H]1C[C@@H]2C[C@@H](CN=C=O)[C@H]1C2.O=C=NC[C@H]1C[C@@H]2C[C@@H](CN=C=O)[C@H]1C2.O=C=NC[C@H]1C[C@H]2C[C@@H](CN=C=O)[C@@H]1C2.O=C=NC[C@H]1C[C@H]2C[C@@H](CN=C=O)[C@@H]1C2
InChI:
InChI=1S/8C11H14N2O2/c4*14-6-12-4-10-2-8-1-9(10)3-11(8)5-13-7-15;4*14-6-12-4-9-1-8-2-10(5-13-7-15)11(9)3-8/h8*8-11H,1-5H2/t2*8-,9-,10+,11+;2*8-,9-,10-,11-;2*8-,9+,10-,11+;2*8-,9-,10+,11+/m1010..../s1 AuxInfo=1/0/N:60,52,59,54,49,56,47,51,58,53,50,55,48,57,46;30,22,29,24,19,26,17,21,28,23,20,25,18,27,16;45,37,44,39,34,41,32,36,43,38,35,40,33,42,31;15,7,14,9,4,11,2,6,13,8,5,10,3,12,1;93,95,97,98,102,99,103,94,92,96,91,100,104,101,105;110,108,112,117,113,118,114,109,111,107,106,119,115,120,116;63,65,67,68,72,69,73,64,62,66,61,70,74,71,75;80,78,82,87,83,88,84,79,81,77,76,89,85,90,86/E:4*(2,3)(4,5)(6,7)(8,9)(10,11)(12,13)(14,15);4*(1,2)(4,5)(6,7)(9,10)(12,13)(14,15)/it:4im;;;;/rA:120OCNCC.oC.eCC.oCNCOC.eCCOCNCC.eC.eCC.eCNCOC.eCCOCNCC.eC.oCC.eCNCOC.oCCOCNCC.oC.oCC.oCNCOC.oCCC.eC.oCC.oCC.eCCCNOCCNOC.oC.eCC.eCC.oCCCNOCCNOC.eC.eCC.oCC.oCCCNOCCNOC.oC.oCC.eCC.eCCCNOCCNO/rB:d1;d+2;s3;s4;s5;s6;s7;s8;s9;d+10;d11;s8;s5s13;s6s13;;d16;d+17;s18;s19;s20;s21;s22;s23;s24;d+25;d26;s23;s20s28;s21s28;;d31;d+32;s33;s34;s35;s36;s37;s38;s39;d+40;d41;s38;s35s43;s36s43;;d46;d+47;s48;s49;s50;s51;s52;s53;s54;d+55;d56;s53;s50s58;s51s58;;s61;s62;s63;s64;s61s65;s61s64;s62;;s68d-69;d69;s66;;s72d+73;d73;;s76;s77;s78;s79;s76s80;s76s79;s77;;s83d-84;d84;s81;;s87d+88;d88;;s91;s92;s93;s94;s91s95;s91s94;s92;;s98d-99;d99;s96;;s102d+103;d103;;s106;s107;s108;s109;s106s110;s106s109;s107;;s113d-114;d114;s111;;s117d+118;d118;/rC:3.5677,6.3404,0;3.6841,4.8539,0;2.489,3.9795,0;2.6348,2.4348,0;1.4399,1.5603,0;1.4399,.0155,0;.4488,-2.2287,0;-1.3291,-1.6459,0;-2.6698,-2.4036,0;-2.6698,-3.9485,0;-3.9232,-4.7063,0;-3.9232,-6.251,0;-.9793,.686,0;-.105,1.8808,0;-.105,-.5674,0;14.8865,6.2859,0;15.0614,4.7996,0;13.808,3.8959,0;13.983,2.4094,0;12.7879,1.535,0;12.7879,.0486,0;11.7969,-2.1957,0;9.9608,-1.6128,0;8.6774,-2.3708,0;8.6774,-3.8571,0;7.4241,-4.6441,0;7.4241,-6.1304,0;10.3395,.6316,0;11.214,1.8266,0;11.214,-.6218,0;26.2631,6.2714,0;26.3798,4.7839,0;25.1847,3.9095,0;25.3596,2.423,0;24.1645,1.5486,0;24.1645,.0623,0;23.1736,-2.1822,0;21.3373,-1.5992,0;20.055,-2.328,0;20.055,-3.8728,0;18.8015,-4.6596,0;18.8015,-6.1461,0;21.7162,.6159,0;22.5906,1.8109,0;22.5906,-.6375,0;3.5587,-9.331,0;3.6753,-10.8184,0;2.4793,-11.6928,0;2.6543,-13.1793,0;1.4592,-14.0538,0;1.4592,-15.5403,0;.4098,-17.8137,0;-1.3681,-17.2016,0;-2.6506,-17.9593,0;-2.6506,-19.4458,0;-3.9039,-20.2328,0;-3.9039,-21.7193,0;-.9892,-15.0155,0;-.1147,-13.8205,0;-.1147,-16.2688,0;13.255,-16.1365,0;14.6878,-15.7128,0;14.6611,-14.1464,0;13.202,-13.5623,0;11.609,-14.0137,0;11.6887,-15.7128,0;12.5117,-14.9694,0;15.7497,-16.7739,0;18.2983,-17.4641,0;17.1834,-16.4019,0;17.9534,-18.9243,0;10.3878,-16.4286,0;8.8224,-14.2791,0;9.0613,-15.7923,0;7.4153,-13.7747,0;27.878,-16.1472,0;29.3105,-15.7235,0;29.284,-14.1835,0;27.8515,-13.5729,0;26.3117,-14.0243,0;26.3647,-15.7235,0;27.2409,-14.9535,0;30.4789,-16.7313,0;33.0276,-17.4216,0;31.9655,-16.3861,0;32.7355,-18.9083,0;25.0373,-16.4393,0;23.4719,-14.2897,0;23.6833,-15.803,0;22.0383,-13.7853,0;.1328,-27.3313,0;1.5664,-26.9341,0;1.5399,-25.3942,0;.0531,-24.8103,0;-1.5131,-25.2882,0;-1.4602,-26.9606,0;-.584,-26.1908,0;2.654,-27.9951,0;5.2025,-28.6854,0;4.1407,-27.6499,0;4.9105,-30.1722,0;-2.6813,-27.6234,0;-4.2466,-25.4739,0;-4.0344,-27.0136,0;-5.6804,-24.9695,0;14.7822,-27.3747,0;16.215,-26.9499,0;16.1883,-25.4101,0;14.7557,-24.7993,0;13.2159,-25.2508,0;13.2689,-26.9499,0;14.145,-26.1799,0;17.383,-27.9578,0;19.9318,-28.6481,0;18.8698,-27.6137,0;19.6398,-30.1346,0;11.9417,-27.6657,0;10.3761,-25.5163,0;10.5886,-27.0296,0;8.9425,-25.0119,0;
Type of substance:
Multi constituent substance
Origin:
Organic
Registered compositions:
3
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes severe skin burns and eye damage, is harmful if swallowed, is harmful to aquatic life with long lasting effects, may cause an allergic skin reaction and may cause allergy or asthma symptoms or breathing difficulties if inhaled.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance causes damage to organs through prolonged or repeated exposure and causes serious eye damage.

Breakdown of all 1 C&L notifications submitted to ECHA

Acute Tox. 2 H330 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
STOT RE 1 H372
Acute Tox. 4 H302 Harmonised Classification
Eye Dam. 1 H318
Aquatic Chronic 3 H412 Harmonised Classification
Skin Sens. 1A H317
Resp. Sens. 1 H334 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
  • Sr

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 2 active registrations under REACH, 1 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area, but tonnage data is confidential.

This substance is used at industrial sites.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following products: polymers.

This substance is used for the manufacture of: plastic products.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities and laboratory work.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray; use only outdoors or in a well-ventilated area; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: Get medical advice/attention if you feel unwell.

Storage statements

Store this substance in a well-ventilated place and keeping container tightly closed.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Charles River Laboratories Den Bosch B.V. OR06, Hambakenwetering 7 5231DD 's-Hertogenbosch Netherlands
  • Mitsui Chemicals Europe GmbH, Oststr. 34 40211 Dusseldorf Germany

Other names

  • (1R,2R,4R,5R)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; (1R,2S,4R,5S)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; (1S,2R,4S,5R)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; (1S,2S,4S,5S)-2,5-bis(isocyanatomethyl)bicyclo[2.2.1]heptane; bis((1r,2R,4s,6S)-2,6-bis(isocyanatomethyl)bicyclo[2.2.1]heptane); bis((1s,2R,4r,6S)-2,6-bis(isocyanatomethyl)bicyclo[2.2.1]heptane)
  • NBDI
  • Reaction mass of 2,5-bis(isocyanatomethyl)-bicyclo[2.2.1]heptane and 2,6-bis(isocyanatomethyl)-bicyclo[2.2.1]heptane
  • 2,5-bis-isocyanatomethyl-bicyclo[2.2.1]heptane

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Odour
Biting (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
-73.5 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
208 °C

Density

Study results
  • 2 studies submitted
  • 1 study processed
R Relative density
1.14 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.14

Vapour pressure

Study results
  • 3 studies submitted
  • 1 study processed
R Vapour pressure
0.006 - 0.037 Pa @ 10 - 25 °C [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0.021 Pa @ 25 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
179 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
179 °C

Auto flammability

Study results
  • 2 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
440 °C @ 100 - 107 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
440 °C

Flammability

Study results
  • 3 studies submitted
  • 1 study processed
C Interpretation of results
Not classified based on GHS criteria (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
GHS criteria not met (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
8 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
8 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
22 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
33

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 19.1 µg/L (1)
Intermittent releases (freshwater) 191 µg/L (1)
Marine water 1.91 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 147 µg/L (1)
Sediment (freshwater) 132 µg/kg sediment dw (1)
Sediment (marine water) 13.2 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 15.2 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 82 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (48 h) 42 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (72 h) 11.4 - 19.1 mg/L [2]
NOEC (72 h) 3.23 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (3 h) 14.7 mg/L [1]
EC50 (30 min) 79.1 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 100 µg/m³ acute toxicity
Acute /short term: (DNEL) 9 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 40 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 5.3 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.4 mg/kg bw/day repeated dose toxicity
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 30 µg/m³ acute toxicity
Acute /short term: (DNEL) 7 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 24 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 3.2 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 830 µg/kg bw/day repeated dose toxicity
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 830 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 100 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 1 201 - 1 842 mg/kg bw (rat) [2]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 54 mg/m³ air (rat) [1]
M/CInterpretations of results
Category 2 based on GHS criteria [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 1 201 mg/kg bw
Inhalation route:
Adverse effect observed LC50 54 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 100 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEC (rat): 120 - 2 030 µg/m³ air [2]

Study data: inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 100 mg/kg bw/day (subacute, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 2.03 mg/m³ (subchronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 120 µg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Study data: in vivo
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
Adverse effect observed (positive)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 200 mg/kg bw/day (subacute, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 200 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant